Results 91 to 100 of about 8,978,019 (319)

Navigating Sample Size Estimation for Qualitative Research

Journal of Medical Evidence
There are well-established rules and methods about sample size estimation in quantitative research approaches. However, qualitative research approaches justify very little about sample size estimation principles and largely depend on subjective ...
Suresh K. Sharma, Shiv Kumar Mudgal, Rakhi Gaur, Jitender Chaturvedi, Satyaveer Rulaniya, Priya Sharma   +5 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sample size calculation formula in "before-after" intervention studies with qualitative outcomes [PDF]

Payesh
Dear Editor, In “before-after" intervention studies with qualitative outcome(s), we should not use the same formula when the outcome(s) are quantitative since the appropriate variance in this formula are not used and thus the sample size will not have ...
Ali Asghar Haeri-Mehrizi, Jila Sadighi
doaj  

Sample Size Estimation in Clinical Trials

National Journal of Community Medicine
Sample size estimation remains as a cornerstone in the meticulous planning and execution of clinical trials, pivotal for ensuring studies possess the requisite statistical power to discern meaningful treatment effects.
Divyangkumar Patel
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Finite-size Scaling Considerations on the Ground State Microcanonical Temperature in Entropic Sampling Simulations [PDF]

, 2015
A. A. Caparica, Cláudio J. DaSilva
openalex   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Sample Size and Saturation in PhD Studies Using Qualitative Interviews

Forum: Qualitative Social Research, 2010
A number of issues can affect sample size in qualitative research; however, the guiding principle should be the concept of saturation. This has been explored in detail by a number of authors but is still hotly debated, and some say little understood.
Mark Mason
doaj  

SAMPLE SIZE DETERMINATION FOR AGRONOMIC EXPERIMENTS

The Iraqi Journal of Agricultural science
Determining sample size to estimate the mean value of a target (infinite) population is of prime importance to have correct results and conclusions. In general, sample sizes differ as the studied objects differ.
Medhat M. Elsahookie, A. A. Dawood
doaj   +1 more source