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Sample size calculation formula in "before-after" intervention studies with qualitative outcomes [PDF]
PayeshDear Editor, In “before-after" intervention studies with qualitative outcome(s), we should not use the same formula when the outcome(s) are quantitative since the appropriate variance in this formula are not used and thus the sample size will not have ...
Ali Asghar Haeri-Mehrizi, Jila Sadighi
doaj
Navigating Sample Size Estimation for Qualitative Research
Journal of Medical EvidenceThere are well-established rules and methods about sample size estimation in quantitative research approaches. However, qualitative research approaches justify very little about sample size estimation principles and largely depend on subjective ...
Suresh K. Sharma +5 more
doaj +1 more source
The Determination of Sample Size
American Journal of Public Health and the Nations Health, 1951 IN the early stages of planning a sample survey one is ordinarily concerned with two different sets of questions, both relating to the survey's feasibility. First of all one is concerned with the possibility of obtaining the required information from the type of respondent considered.
openaire +3 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Sample Size Estimation in Clinical Trials
National Journal of Community MedicineSample size estimation remains as a cornerstone in the meticulous planning and execution of clinical trials, pivotal for ensuring studies possess the requisite statistical power to discern meaningful treatment effects.
Divyangkumar Patel
doaj +1 more source
, 2007 Correlated samples have been frequently avoided in case-control genetic association studies in part because the methods for handling them are either not easily implemented or not widely known.
Daniel Kastner +5 more
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
, 2019 Samuel Hawley,1 M Sanni Ali,1,2 Klara Berencsi,1 Andrew Judge1,3,4 Daniel Prieto-Alhambra1,5 1Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; 2Faculty of
Berencsi K +4 more
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source