Results 161 to 170 of about 17,778,637 (310)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Discard sampling of the Dutch pelagic freezer fishery in 2008 and 2009
, 2010 This report contains the results of the discard sampling programme on the Dutch pelagic trawl fisheries in the North East Atlantic in 2008 and 2009, which was instigated as part of the EC regulation 1543/2000 and 1693/2001 on data collection in European ...
Helmond, A.T.M., van +3 more
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Integral correlation for uneven and differently sampled data, and its application to the Law Dome Antarctic climate record. [PDF]
Sci Rep, 2020 Roberts JL +12 more
europepmc +1 more source
Telling from Discrete Data Whether the Underlying Continuous-Time Model is a Diffusion [PDF]
Asset returns have traditionally been modeled in the literature as following continuous-time Markov processes, and in many cases diffusions. Can discretely sampled financial rate data help us decide which continuous-time models are sensible?
Yacine Ait-Sahalia
core
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Domain Transform Network for Photoacoustic Tomography from Limited-view and Sparsely Sampled Data. [PDF]
Photoacoustics, 2020 Tong T +7 more
europepmc +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Learning from irregularly sampled data for endomicroscopy super-resolution: a comparative study of sparse and dense approaches. [PDF]
Int J Comput Assist Radiol Surg, 2020 Szczotka AB +5 more
europepmc +1 more source