Results 211 to 220 of about 875,209 (309)

The small molecule simufilam dose‐dependently attenuates the worsening of seizures in a mouse model of tuberous sclerosis complex

open access: yesEpilepsia, EarlyView.
Abstract Objective Novel epilepsy treatments for patients with tuberous sclerosis complex (TSC) and focal cortical dysplasia type II (FCDII) are urgently needed. In these patients, mutations in the mechanistic target of rapamycin (mTOR) pathway genes lead to mTOR hyperactivity and focal cortical malformations that frequently cause intractable epilepsy ...
Branden Stansley   +11 more
wiley   +1 more source

A consensus roadmap for post‐traumatic epilepsy: Clinical biomarkers, research priorities, policy barriers, and pathways to interventional trials

open access: yesEpilepsia, EarlyView.
Abstract Understanding the mechanisms underlying post‐traumatic epilepsy (PTE) following traumatic brain injury (TBI), and developing strategies to prevent or modify its progression, has been the focus of large collaborative efforts within the epilepsy and TBI research communities for over a decade.
Elisa R. Zanier   +82 more
wiley   +1 more source

Prolonged fenfluramine use in open‐label studies of Dravet or Lennox–Gastaut syndromes: Long‐term safety, tolerability, patient global functioning, and considerations for interpreting effectiveness

open access: yesEpilepsia, EarlyView.
This graphical abstract provides an overview of the content from this open‐label extension study of fenfluramine use in patients with Dravet syndrome or Lennox‐Gastaut syndrome. Abstract Objective Long‐term safety and global functioning are reported in patients with Dravet syndrome (DS) or Lennox–Gastaut syndrome (LGS) treated with fenfluramine in an ...
Antonio Gil‐Nagel   +18 more
wiley   +1 more source

Neighborhood built environment, psychosocial stressors, and telomere length of birth parents and their newborns from San Francisco, California. [PDF]

open access: yesJ Expo Sci Environ Epidemiol
Cushing LJ   +8 more
europepmc   +1 more source

Weak‐Story Mitigation and Drift Redistribution in Moment‐Resisting Frames Using Stepping Rocking Walls

open access: yesEarthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT This study investigates the seismic response of moment‐resisting frames retrofitted with a stepping rocking wall, with emphasis on weak‐story mitigation and residual drift reduction under both ordinary and pulse‐like ground motions. Nonlinear response‐history analyses are conducted on 9‐story and 20‐story SAC Los Angeles frames.
Mehrdad Aghagholizadeh
wiley   +1 more source

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