Results 141 to 150 of about 49,451 (306)
Professional sanction in business criminal law : a contribution to a general theory of sanction
, 2012 Le sujet par son intitulé "la sanction professionnelle en droit pénal des affaires" évoque à chacun l'idée que la sanction professionnelle serait la sanction applicable en droit pénal des affaires.
Baldes, Olivia
core
THE MORE FAVORABLE CONTRAVENTION LAW IN THE CONTEXT OF RO-E-TRANSPORT: CHALLENGES AND CRITICAL CONSIDERATIONS [PDF]
Challenges of the Knowledge SocietyThe year 2024 was an extremely dynamic one regarding the changes made to the GEO no. 41/2022, which establishes the national system for monitoring road freight transport, RO-e-transport, particularly concerning the sanctioning regime.
Narcisa-Victoria DĂRĂBAN
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
L'effectivité de la sanction pénale: (Préface de Sylvie Cimamonti)
, 2020 International audienceLa question de l’effectivité de la sanction pénale fait régulièrement débat. La sanction pénale serait, bien souvent, partiellement effective. Il faut dire que selon une acception classiquement répandue, l’effectivité de la sanction
Tzutzuiano, Catherine
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The breach of contract sanction
, 2016 Cette thèse a pour objet l'étude de la sanction du manquement contractuel. Le cadre de cette recherche est tracé par l'examen comparé de cette notion dans le droit français positif et le droit libanais des obligations.
Boukhdoud, Bahaa
core
A game theoretical analysis of economic sanction [PDF]
, 2011 Economic sanction has been widely used and increasingly a popular tool in maintaining peace and political stability in the world. The use of economic sanction, as opposed to the use of military power, to punish target countries have been supported by the
Shidiqi, khalifany ash +1 more
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source