Results 91 to 100 of about 6,691 (192)

Targeting Human Dendritic Cells with Lewis X Modified Liposomes [PDF]

, 2010
In this short report, we demonstrate that liposomes bearing the Lewis X trisaccharide on the surface (“Awesosomes”) efficiently target human dendritic cells.
Lucie Kalvodova, Yongmin Zhang
core   +2 more sources

TUMOR NECROSIS FACTOR ALPHA (TNFα) in SANDHOFF DISEASE PATHOLOGY [PDF]

, 2014
Sandhoff disease (SD) is a monogenic lysosomal storage disorder caused by a lack of a functional β-subunit of the beta-hexosaminidase A and B enzymes.
Abou-Ouf, Hatem A.
core  

Tay Sachs-ова болест -приказ на случај [PDF]

, 2019
Tay Sachs's disease is a rare disorder, genetically inherited from parents of a child. It is caused by the absence of an enzyme that helps dissolve the fatty substances.
Golubovik Arsovska, Milena, Isjanovski, Igor   +1 more
core   +2 more sources

Late-onset Tay-Sachs disease [PDF]

, 2017
We discuss the assessment and differential diagnoses of a young adult Hungarian man with a 1-year history of a progressive and symmetric amyotrophic lateral sclerosis-like syndrome, along with irregular action tremor and stimulus-sensitive myoclonus of ...
Andrew W Barritt, Basil H Ridha, Bocchetta, Chen, Cooper-Knock, Elstein, Frey, Ghasemi, MacQueen, Neudorfer, Neudorfer, Osher, P Nigel Leigh, Shapiro, Stryer, Stuart J Anderson, Suzuki, Turner, Zaroff   +18 more
core   +1 more source

Inhibition of astrocytic adenosine receptor A2A attenuates microglial activation in a mouse model of Sandhoff disease

Neurobiology of Disease, 2018
Astrocyte-microglia communication influences the onset and progression of central nervous system (CNS) disorders. In this study, we determined how chronic inflammation by activated astrocytes affected and regulated CNS functions in Sandhoff disease (SD),
Yasuhiro Ogawa, Eiri Furusawa, Takahiro Saitoh, Hiroki Sugimoto, Takumi Omori, Shinya Shimizu, Hisatsugu Kondo, Mika Yamazaki, Hitoshi Sakuraba, Kazuhiko Oishi   +9 more
doaj   +1 more source

A clinical review on megalencephaly: A large brain as a possible sign of cerebral impairment. [PDF]

, 2017
Megalencephaly and macrocephaly present with a head circumference measurement 2 standard deviations above the age-related mean. However, even if pathologic events resulting in both megalencephaly and macrocephaly may coexist, a distinction between these ...
Corsello G, Falsaperla R, Parano E, Pavone P, Praticò AD, Rizzo R, Ruggieri M   +6 more
core   +1 more source

Sortilin is associated with the chlamydial inclusion and is modulated during infection [PDF]

, 2016
© 2016. Published by The Company of Biologists Ltd. Chlamydia species are obligate intracellular pathogens that have a major impact on human health. The pathogen replicates within an intracellular niche called an inclusion and is thought to rely heavily ...
Huston, WM, Kerr, MC, Teasdale, RD, Teo, WX   +3 more
core   +1 more source

Characterization of Human Recombinant β1,4-GalNAc-Transferase B4GALNT1 and Inhibition by Selected Compounds

Molecules
Gangliosides are essential for membrane functions, cell recognition, and maintenance of the nervous system. GM2 gangliosidosis is a group of rare genetic lysosomal storage diseases that includes Tay-Sachs disease (TSD), Sandhoff disease (SD), and AB ...
Iram Abidi, Alexander N. Kocev, Jonathan L. Babulic, Chantelle J. Capicciotti, Jagdeep Walia, Inka Brockhausen   +5 more
doaj   +1 more source

Membrane lipids and their degradation compounds control GM2 catabolism at intralysosomal luminal vesicles

Journal of Lipid Research, 2019
The catabolism of ganglioside GM2 is dependent on three gene products. Mutations in any of these genes result in a different type of GM2 gangliosidosis (Tay-Sachs disease, Sandhoff disease, and the B1 and AB variants of GM2 gangliosidosis), with GM2 as ...
Susi Anheuser, Bernadette Breiden, Konrad Sandhoff   +2 more
doaj   +1 more source

Life-Limiting Peripheral Organ Dysfunction in Feline Sandhoff Disease Emerges after Effective CNS Gene Therapy. [PDF]

Ann Neurol, 2023
Johnson AK, McCurdy VJ, Gray-Edwards HL, Maguire AS, Cochran JN, Gross AL, Skinner HE, Randle AN, Shirley JL, Brunson BL, Bradbury AM, Leroy SG, Hwang M, Rockwell HE, Cox NR, Baker HJ, Seyfried TN, Sena-Esteves M, Martin DR.   +18 more
europepmc   +1 more source