Results 111 to 120 of about 6,691 (192)

The Broad Spectrum HDAC Inhibitor PCI-24781 Induces Caspase- and ROS-Dependent Apoptosis and is Synergistic with Bortezomib in Lymphoma [PDF]

, 2008
We investigated the cytotoxicity and biology of the novel broad-spectrum hydroxamic acid-based histone deacetylase inhibitor (HDACi), PCI-24781. PCI-24781 was studied alone and combined with bortezomib in Hodgkin lymphoma (L428) and non-Hodgkin's ...
Andrew Evens, Joseph Buggy, Kevin David, Lauren Mauro, Leo Gordon, Mint Sirisawad, Richard Miller, Savita Bhalla, Sheila Prachand, Sriram Balasubramanian   +9 more
core   +1 more source

Effect of Yuzu (Citrus junos) Seed Limonoids and Spermine on Intestinal Microbiota and Hypothalamic Tissue in the Sandhoff Disease Mouse Model. [PDF]

Med Sci (Basel), 2021
Minamisawa M, Suzumura T, Bose S, Taniai T, Kawai G, Suzuki K, Yamaguchi A, Yamanaka S.   +7 more
europepmc   +1 more source

Therapeutic benefit after intracranial gene therapy delivered during the symptomatic stage in a feline model of Sandhoff disease. [PDF]

Gene Ther, 2021
McCurdy VJ, Johnson AK, Gray-Edwards HL, Randle AN, Bradbury AM, Morrison NE, Hwang M, Baker HJ, Cox NR, Sena-Esteves M, Martin DR.   +10 more
europepmc   +1 more source

Plasma membrane remodeling in GM2 gangliosidoses drives synaptic dysfunction.

PLoS Biology
Glycosphingolipids (GSL) are important bioactive membrane components. GSLs containing sialic acids, known as gangliosides, are highly abundant in the brain and diseases of ganglioside metabolism cause severe early-onset neurodegeneration. The ganglioside
Alex S Nicholson, David A Priestman, Robin Antrobus, James C Williamson, Reuben Bush, Shannon J McKie, Henry G Barrow, Emily Smith, Kostantin Dobrenis, Nicholas A Bright, Frances M Platt, Janet E Deane   +11 more
doaj   +1 more source

Abnormal epiphyseal development in a feline model of Sandhoff disease. [PDF]

J Orthop Res, 2020
McNulty MA, Prevatt PB, Nussbaum ER, Randle AN, Johnson AK, Hudson JA, Gray-Edwards HL, Sena-Esteves M, Martin DR, Carlson CS.   +9 more
europepmc   +1 more source

Beneficial Effects of Acetyl-DL-Leucine (ADLL) in a Mouse Model of Sandhoff Disease. [PDF]

J Clin Med, 2020
Kaya E, Smith DA, Smith C, Boland B, Strupp M, Platt FM.   +5 more
europepmc   +1 more source

Brain endothelial specific gene therapy improves experimental Sandhoff disease. [PDF]

J Cereb Blood Flow Metab, 2020
Dogbevia G, Grasshoff H, Othman A, Penno A, Schwaninger M.   +4 more
europepmc   +1 more source

Simplifying complexity: genetically resculpting glycosphingolipid synthesis pathways in mice to reveal function [PDF]

, 2014

core   +1 more source

A feasibility study of mHealth and wearable technology in late onset GM2 gangliosidosis (Tay-Sachs and Sandhoff Disease). [PDF]

Orphanet J Rare Dis, 2020
Davies EH, Johnston J, Toro C, Tifft CJ.
europepmc   +1 more source

Bioprinting neural tissue to decode Sandhoff disease: promise and barriers. [PDF]

Ann Med Surg (Lond)
Ullah SH, Waqas M, Fatima M, Talha M, Rehman UU.   +4 more
europepmc   +1 more source