Results 171 to 180 of about 224,524 (254)

3′‐UTR Hypermethylation and ABA Signaling Coordinate Transcriptional Activation of SWEET14 for High Sugar Accumulation in Citrus

Advanced Science, EarlyView.
Hypermethylation of CliSWEET14 3′‐UTR relieves ClibHLH105‐mediated transcriptional repression, together with ABA signaling‐mediated activation of the CliABF3‐CliNAC56 cascade, boosts CliSWEET14 expression and sucrose accumulation in citrus. ABSTRACT Sugar accumulation is pivotal for fruit quality, yet the molecular regulation of this process remains ...
Yike Zeng, Yue Wang, Yilei Wang, Haowei Chen, Qiyu Chen, Wei Xiao, Aoqing Zhang, Xin Jiang, Xiangming Shang, Zhicheng Yang, Xi Zeng, Wenqiang Hu, Chunlong Li, Ji‐Hong Liu   +13 more
wiley   +1 more source

Accuracy comparison of direct Sanger sequencing, immunohistochemistry, and droplet digital polymerase chain reaction in detecting <i>BRAF</i> mutations in papillary thyroid carcinoma: a retrospective diagnostic accuracy study. [PDF]

Ann Surg Treat Res
Oh MY, Tang MH, Song YS, Yi KH, Kim YA, Han M, Chai YJ.   +6 more
europepmc   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

Validating a clinically based MS-MLPA threshold through comparison with Sanger sequencing in glioblastoma patients. [PDF]

Clin Epigenetics
Lhotska H, Janeckova K, Cechova H, Macoun J, Aghova T, Lizcova L, Svobodova K, Hodanova L, Konecna D, Soukup J, Kramar F, Netuka D, Zemanova Z.   +12 more
europepmc   +1 more source

MAGI3 Acts as an Intestinal Epithelial Gatekeeper in Inflammation‐Associated Colorectal Cancer by Suppressing the STAT3‐CCL2 Axis and TAM‐Mediated Immunosuppression

Advanced Science, EarlyView.
Our study identifies MAGI3 as an intestinal epithelial gatekeeper that restrains inflammation‐associated colorectal tumorigenesis but is itself suppressed under highly inflammatory conditions. MAGI3 deficiency activates the STAT3‐CCL2 signaling, thereby promoting TAM‐mediated immunosuppression and inflammation‐associated colorectal tumor progression ...
Yumeng Yang, Zhigang Bai, Haibo Wang, Yu Guo, Yan Zhang, Meihan Hu, Shuaikang Fan, Ran Song, Tongmei Zhang, Mengqi Deng, Xiaomei Yang, Zhongtao Zhang, Junqi He   +12 more
wiley   +1 more source

Genetic profiling of osteosarcoma in an adolescent using a next‑generation sequencing panel and Sanger sequencing: A case report and review of the literature. [PDF]

Biomed Rep
Chantre-Justino M, Silvestre RT, De Castro TL, Luz E, Pinheiro RCES, Caruso A, Lopes ACS, Meohas W, Alves G, Ornellas MHF.   +9 more
europepmc   +1 more source

Combinatorial Tuning of Multigene Biosynthetic Pathways based on RNA Interference

Advanced Science, EarlyView.
Small RNA sequencing identifies candidate endogenous Pol III promoters, and subsequent fluorescence screening measures knockdown efficiency to assess promoter strength. Combining promoter strength and shRNA target position enables fine‐grained RNAi regulation of multigene pathways. This strategy enhances β‐carotene production in Schizochytrium sp.
Zixu Zhang, Yingshuang Xu, Zijia Li, Fei Du, Wang Ma, Guang Yang, Xiaoman Sun   +6 more
wiley   +1 more source

Vaccine antigen-based genotyping of <i>Bordetella pertussis</i> by direct Sanger sequencing of clinical samples in Peru from 2018 to 2019. [PDF]

Microbiol Spectr
Juscamayta-López E, Vega-Abad B, Valdivia F, Soto MP, Horna H, García-de-la-Guarda R.   +5 more
europepmc   +1 more source

TIPIN Couples Epigenetic Rewiring to EGFR Stabilization and Lenvatinib Resistance in Liver Cancer

Advanced Science, EarlyView.
DNA hypomethylation elevates TIPIN expression in liver cancer. TIPIN competes with E3 ligase c‐Cbl for the EGFR intracellular domain, inhibiting EGFR ubiquitination and lysosomal degradation to sustain oncogenic EGFR‐ ERK signaling. High TIPIN confers lenvatinib resistance, while TIPIN depletion restores drug sensitivity in liver cancer. ABSTRACT Aims:
Xing Jia, Shiyu Zhang, Yangbo Tang, Shinuo Chen, Xingxin Zhu, Junran Chen, Suchen Bian, Lei Zheng, Chi Zhang, Haojing Ma, Wengfeng Song, Cheng Jin, Mengqiao Zhou, Haiyang Xie, Qinglin Li, Penghong Song   +15 more
wiley   +1 more source

Evaluation of SNaPshot and Sanger sequencing for the detection of KRAS and NRAS mutations in a sample of Venezuelan patients with colorectal cancer. [PDF]

Ecancermedicalscience
Rodríguez-Carrascal D, Puche R, Acosta M, Ramírez CD.   +3 more
europepmc   +1 more source