Results 201 to 210 of about 292,213 (250)

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, EarlyView.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source

Genotyping not required for sustained effectiveness of long-acting cabotegravir plus rilpivirine: evidence from the RELATIVITY cohort. [PDF]

AIDS
Buzón-Martín L, Bernardino JI, Galindo Puerto MJ, Martín-Torres J, Alemán Valls MR, Torralba González de Suso M, Díaz de Santiago A, Fanjul F, Rodríguez A, Cabello Úbeda A, Pedrero-Tomé R, Crusells Canales MJ, Calzado Isbert S, Aguilera García M, Hidalgo Tenorio C, Morano L, Vinuesa García D, de Andrés David C, Bernal Morell E, Martínez Álvarez RM, Cabello Clotet N, Tiraboschi J, Gimeno García A, Vivancos MJ, Troya J, the RELATIVITY Cohort Group .   +25 more
europepmc   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Impact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry. [PDF]

Sci Rep
Oblitas CM, Demelo-Rodríguez P, Barrera-López L, Galeano-Valle F, Rubio-Rivas M, Luque Del Pino J, Giner Galvañ V, Paredes-Ruíz D, Fernández-Madera Martínez R, Gericó Aseguinolaza M, Gómez-Huelgas R, Fernández FA, Torres Peña JD, Martín González JI, Méndez-Bailón M, Monge Monge D, Freire Castro SJ, Pastor Valverde C, Rodilla-Sala E, Guzmán García M, Rivas-Carmenado M, Gallo CM, Perea Ribis MA, Casas-Rojo JM, Millán Núñez-Cortés J, SEMICOVID-19 Network.   +25 more
europepmc   +1 more source

Exercise‐related microRNAs in Caenorhabditis elegans regulate calcium homeostasis and mitochondrial dynamics: Conserved pathways, divergent microRNAs

The FEBS Journal, EarlyView.
Exercise‐related microRNAs cel‐miR‐249‐3p and cel‐miR‐77‐5p in C. elegans regulate lifespan, fitness, mitochondrial morphology and membrane potential. Although lacking direct mammalian orthologs, H2O2‐induced microRNAs mmu‐miR‐181a‐5p and mmu‐miR‐378a‐3p regulate myogenesis, autophagy, mitochondrial content and respiration in murine myoblasts ...
Qin Xia, Jiwang Tang, José C. Casas‐Martinez, Penglin Li, Maria Borja‐Gonzalez, Leo R Quinlan, Katarzyna Goljanek‐Whysall, Brian McDonagh   +7 more
wiley   +1 more source

Impact of the initial administration of an antiretroviral drug with latency reversal properties on the HIV reservoir size. [PDF]

Sci Rep
De La Torre Tarazona E, Moraga E, Vaquer R, Sánchez-Palomino S, de Lazzari E, Luna L, Vicens-Artés S, García Fraile LJ, Peraire J, Garcia-Gasalla M, Balsalobre L, Guillén Martínez S, López Cortés LF, Jarrín I, Serrano-Villar S, Alcamí J, Moreno S, CoRIS Cohort.   +17 more
europepmc   +1 more source

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

The FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero, Juan Luis Pacheco‐Garcia, Pavla Vankova, Dmitry Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin‐Garcia, Petr Man, Angel Luis Pey, Milagros Medina   +8 more
wiley   +1 more source

Influence of Florfenicol Treatments on Marine-Sediment Microbiomes: A Metagenomic Study of Bacterial Communities in Proximity to Salmon Aquaculture in Southern Chile. [PDF]

Antibiotics (Basel)
Lynch S, Thomson P, Santibañez R, Avendaño-Herrera R.   +3 more
europepmc   +1 more source

Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism

The FEBS Journal, EarlyView.
AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney, James Griffin, Nouf Khan, Balnur Ibrash, Matthew J. O'Connor, Tomas Venit, Elizabeth Mayela Ambrosio, Spiros A. Pergantis, Elke Ober, Piergiorgio Percipalle, Kirsten C. Sadler   +10 more
wiley   +1 more source

Genetic evolution and relapse-associated mutations in adult T-cell acute lymphoblastic leukemia patients treated in PETHEMA trials. [PDF]

Hemasphere
González-Gil C, Lopes T, Morgades M, Fuster-Tormo F, Montesinos P, Medina CR, Hermosín L, González-Martínez T, Queipo MP, González-Campos J, Martínez-Sánchez P, Díaz-Beya M, Coll R, Maluquer C, Zamora L, Artola T, Vall-Llovera F, Tormo M, Torrent A, Martínez-Laperche C, Gil-Cortés C, Barba P, Cervera M, Ribera J, Fernández-Delgado M, Ayala R, Cladera A, Mateos MC, Vidal MJ, Feliu J, Torres A, Azaceta G, Calasanz MJ, Bigas A, Esteller M, Orfao A, Ribera JM, Genescà E.   +37 more
europepmc   +1 more source