Results 181 to 190 of about 292,213 (250)

Influence of the Gut Microbiota on Acute Ischemic Stroke Functional Outcomes at Three Months. [PDF]

Eur J Neurol
Lledós M, Prats-Sánchez L, Muiño E, Cullell N, Llucià-Carol L, Cárcel-Márquez J, Gallego-Fabrega C, Martín-Campos JM, Marín R, Aguilera-Simón A, Guasch-Jiménez M, Ezcurra-Díaz G, Camps-Renom P, Del Mar Freijo M, Martí-Fàbregas J, Fernández-Cadenas I.   +15 more
europepmc   +1 more source

Glycolytic metabolism of CD8+ T‐cells affects susceptibility to human leukocyte antigen‐mediated abacavir‐induced hypersensitivity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Drug hypersensitivity reactions (DHRs) associated with a specific human leukocyte antigen (HLA) allotype do not manifest uniformly in all individuals within an HLA model population. This scenario highlights the complexity of predicting drug hypersensitivity reaction risk without considering additional factors ...
Takeshi Susukida, Yuchen Sun, Noriaki Arakawa, Takuya Hirao, Tadahaya Mizuno, Shigeki Aoki, Kousei Ito, Yoshihiro Hayakawa   +7 more
wiley   +1 more source

Immunosuppressed patients with COVID-19 pneumonia in ICU: clinical characteristics and factors influencing outcomes. [PDF]

Pneumonia (Nathan)
Galli F, Forin E, Motos A, Molina Saldarriaga FJ, Gabarrus A, Canseco J, Fernandez-Barat L, Barbeta E, Calabretta D, Ceccato A, Bermejo-Martin JF, Ferrer R, Riera J, Penuelas O, Lorente JA, de Gonzalo-Calvo D, Menendez R, Gonzalez J, Palomeque A, Soler-Comas A, Amaya-Villar R, Anon JM, Marino AB, Barbera C, Barberan J, Ortiz AB, Bustamante-Munguira E, Caballero J, Canton-Bulnes ML, Perez CC, Carbonell N, Catalan-Gonzalez M, de Frutos R, Franco N, Galban C, Lago AL, Gumucio-Sanguino VD, Del Carmen de la Torre M, Diaz E, Estella A, Gallego Curto E, Garcia-Garmendia JL, Gomez JM, Huerta A, Jorge Garcia RN, Loza-Vazquez A, Marin-Corral J, Martin Delgado MC, Martinez de la Gandara A, Martinez Varela I, Lopez Messa J, Albaiceta GM, Nieto MT, Novo MA, Penasco Y, Perez-Garcia F, Pozo-Laderas JC, Ricart P, Sagredo V, Sanchez-Miralles A, Sancho Chinesta S, Roche-Campo F, Socias L, Sole-Violan J, Suarez-Sipmann F, Tamayo Lomas L, Trenado J, Ubeda A, Valdivia LJ, Vidal P, Boado MV, Rodriguez A, Ferrer M, Barbe F, Torres A, CIBERESUCICOVID Project investigators (COV20/00110, ISCIII).   +76 more
europepmc   +1 more source

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, EarlyView.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source

Laboratory and Clinical Practices in the Study of Coeliac Disease in Children and Adults: Recommendations from a Spanish Multicentre Survey. [PDF]

Nutrients
Aguado R, Irure-Ventura J, Vargas ML, Roy G, Barrios Y, Martínez-Martínez L, Rodríguez B, Montes-Cano MA, López-Hoyos M, Jurado A, GEAI-SEI.   +10 more
europepmc   +1 more source

Polarized effects of adenosine on blood–brain barrier integrity: Tightening from the luminal and opening from the abluminal side

British Journal of Pharmacology, EarlyView.
Background and Purpose Adenosine as a signalling molecule modifies blood–brain barrier (BBB) tightness in pathological conditions. Our aim was to investigate the direct and polarized effects of adenosine on the BBB using co‐culture and in vivo models. Experimental Approach The expression of adenosine receptors was measured by qRT‐PCR.
András Harazin, Gabriela Hurtado‐Alvarado, Lilla Barna, Arturo Contis‐Montes de Oca, Rocío Ruíz‐Manzano, Krisztián Laczi, András Kincses, Gergő Porkoláb, Gang Chen, Beatriz Gómez‐González, Mária A. Deli   +10 more
wiley   +1 more source

Real-world experience with belimumab-based triple therapy in proliferative lupus nephritis: data from the BEL-SPAIN Registry. [PDF]

Lupus Sci Med
Vidal-Montal P, Fabregat A, Altabás-González I, Pego-Reigosa JM, Hernández-Martínez A, Rua-Figueroa I, Salman-Monte T, Moriano C, Tejera Segura B, Vela P, Pareja-Martínez A, García-Cirera S, García-Villanueva MJ, Garrote-Corral S, Heredia S, Riancho-Zarrabeitia L, Manrique-Arija S, Bernárdez J, Magallares B, Torrente-Segarra V, Frade-Sosa B, Gómez-Puerta JA, Martinez-Barrio J, Narvaez J, BELIMUMAB Multicenter Spanish Register Group (BEL-SPAIN).   +24 more
europepmc   +1 more source

Effects of Common Food Additives Kappa‐, Iota‐ and Lambda‐Carrageenans on Intestinal Epithelial Cell Activation and Barrier Disruption

Clinical &Experimental Allergy, EarlyView.
Carrageenans, widely used food additives, disrupted intestinal epithelial integrity in a gut‐on‐a‐chip model. All types (κ‐, ɩ‐, λ‐) induced cytotoxicity, inflammation and tight junction (TJ) disruption, triggering TNF‐mediated immune responses. λ‐Carrageenan had the most severe effects, supporting the Epithelial Barrier Theory linking food additives ...
Na Sun, Yagiz Pat, Huseyn Babayev, Sena Ardicli, Ismail Ogulur, Xianting Bu, Manru Li, Shuqi Jia, Beate Rückert, Raja Dhir, Kari C. Nadeau, Mubeccel Akdis, Cezmi A. Akdis, Duygu Yazici   +13 more
wiley   +1 more source

Deciphering the role of complement system genes in pancreatic cancer susceptibility and prognosis. [PDF]

Nat Commun
Langtry A, Rabadan R, Alonso L, Filip I, Sabroso-Lasa S, Moreno-Oya A, Lawlor R, Carrato A, Alvarez-Gallego R, Iglesias M, Molero X, Löhr MJ, Michalski CW, Perea J, O'Rorke M, Barberà VM, Tardón A, Farré A, Muñoz-Bellvís L, Crnogorac-Jurcevic T, Domínguez-Muñoz E, Gress TM, Greenhalf W, Sharp L, Balsells J, Costello E, Kleeff J, Kong B, Mora J, O'Driscoll D, Scarpa A, Ye W, Real FX, López de Maturana E, Malats N, PanGenEU Consortium Investigators.   +35 more
europepmc   +1 more source

Glove Reuse Limits in Hair Dyeing: Permeation of p‐Phenylenediamine and Aminophenols Through Natural Rubber Latex and Neoprene After Repeated Washing

Contact Dermatitis, EarlyView.
Disposable glove reuse reduced chemical protection during repeated hair‐dye exposure. Under ASTM F739 testing, natural‐rubber‐latex deteriorated rapidly after one reuse, whereas neoprene performed better initially but also declined over repeated cycles. Wash type had no significant effect. These findings support single‐use only and discourage the reuse
Pei‐Ting Jian, Yu‐Wen Lin
wiley   +1 more source