Results 191 to 200 of about 292,213 (250)

A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population. [PDF]

J Clin Med
Peypoch O, Calsina Juscafresa L, Vega-Méndez A, Lobato-Delgado B, Fité J, Soto B, Nieto L, de la Rosa Estadella M, Uribezubia A, Romero JM, Plana E, Miralles M, Clarà A, Dilmé J, Soria JM, Camacho M, Martinez-Perez A, Sabater-Lleal M.   +17 more
europepmc   +1 more source

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Eight millennia of continuity of a previously unknown lineage in Argentina. [PDF]

Nature
Maravall-López J, Motti JMB, Pastor N, Tavella MP, Fabra M, Babot P, Bonomo M, Cornero SE, Lamenza GN, Leon DC, Miranda de Zela PC, Politis GG, Angeletti SC, Cattáneo GR, Dantas M, Drube H, Gonzalez Baroni LG, Hocsman S, Izeta AD, Moralejo RA, Aldazabal V, Basso DM, Bayón C, Couso MG, D'Andrea U, Del Río P, Figueroa GG, Frontini R, Gonzalez ME, Laguens AG, Martínez JG, Messineo PG, Nores B, Olivera DE, Sario GM, Sbattella A, Scabuzzo C, Tavarone AM, Vecchi R, Callan K, Caughran E, Estrada O, Frost T, Iliev L, Kearns A, Kellogg J, Krettek KL, Lawson AM, Mah M, Manjila N, Micco A, Patterson I, Qiu L, Roca-Rada X, Soos G, Webb PA, Workman JN, Rohland N, Patterson N, Lazaridis I, Fehren-Schmitz L, Posth C, Llamas B, Mallick S, Demarchi DA, Cabana GS, Reich D, Nores R.   +67 more
europepmc   +1 more source

Lack of association between vaccine‐induced immune thrombocytopenia and thrombosis and HLA loci in a large cohort

British Journal of Haematology, EarlyView.
Linda Schönborn, Ana Tzvetkova, Thomas Thiele, Uwe Völker, Sabine Ameling, Sören Franzenburg, Lars Kaderali, Andreas Greinacher   +7 more
wiley   +1 more source

Anemia‐associated mutations disrupt the CDIN1‐Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA‐I) disease

The FEBS Journal, EarlyView.
Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal, Tomas Brom, Ivona Nečasová, Tomáš Janovič, Pavel Veverka, Naina Verma, Lukáš Uhrík, Lenka Hernychova, Ctirad Hofr   +8 more
wiley   +1 more source

Integrative taxonomy uncovers <i>Clinostomum chaacci</i> and an unidentified congeneric metacercaria infecting <i>Hoplosternum littorale</i> (Siluriformes: Callichthyidae) in the Peruvian Amazon Basin. [PDF]

Food Waterborne Parasitol
Chero JD, Ñacari LA, Murrieta Morey GA, Cruces CL, Cacique E, Huaman N, Lopez D, Mondragón-Martínez A, Martínez-Rojas R, Yunis-Aguinaga J.   +9 more
europepmc   +1 more source

The competitive interplay of 12‐oxophytodienoic acid (OPDA), protein thiols, and glutathione

The FEBS Journal, EarlyView.
12‐Oxophytodienoic acid (OPDA) is a phytohormone involved in plant growth and stress defense. Due to its cyclopentenone moiety, OPDA can form Michael adducts with thiol‐containing compounds such as glutathione and cysteine residues of proteins, resulting in alterations of the cellular redox regulatory network.
Madita Knieper, Ruben Schwarz, Lara Vogelsang, Jens Sproß, Armağan Kaya, Maike Bittmann, Harald Gröger, Andrea Viehhauser, Karl‐Josef Dietz   +8 more
wiley   +1 more source

Taxonomic clarifications, a new combination, and three new species of Neotropical <i>Rinorea</i> (Violaceae). [PDF]

PhytoKeys
Hoyos-Gómez SE, Ballard HE, Callejas Posada R, Wahlert GA.   +3 more
europepmc   +1 more source

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

The FEBS Journal, EarlyView.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova, Caroline M. Ferreira, Katrina P. Montales, Francisco Villalobos, Alexandra J. Brownstein, Rebeca Acín‐Pérez, Gabrielly S. Ferreira, Anthony E. Jones, Linsey Stiles, Ajit S. Divakaruni, Marc Liesa, Orian S. Shirihai, Marcus F. Oliveira   +12 more
wiley   +1 more source

Discovery of RUVBL1 as a Target of the Marine Alkaloid Caulerpin via MS-Based Functional Proteomics. [PDF]

Mar Drugs
Capuano A, D'Urso G, Capasso L, Brancaccio E, Gazzillo E, Carbone M, Mollo E, Lauro G, Chini MG, Bifulco G, Nebbioso A, Casapullo A.   +11 more
europepmc   +1 more source