Results 101 to 110 of about 575,667 (310)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Santa Cruz Church built by Spaniards at Orona Algeria (photograph)

open access: yes, 2017
Santa Cruz Church built by Spaniards at Orona ...

core  

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li   +11 more
wiley   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

open access: yesAdvanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio   +11 more
wiley   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

open access: yesAdvanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo   +7 more
wiley   +1 more source

El problema del pulgón en Sauces

open access: yes, 2003
Los ataques de pulgones se ha incrementado en los últimos años, posiblemente consecuencia de los inviernos benignos que se sucedieron desde 1995. El pulgón se ha adaptado con éxito en la provincia de Santa Cruz y actualmente puede ser considerado una ...
Cirielli, Javier, Diaz, Boris Gaston
core  

Microfabricated Anisotropic Myobundles for the Scalable Production of Cardiac Tissue Grafts

open access: yesAdvanced Functional Materials, EarlyView.
Controlling the anisotropy of cardiac tissue remains an outstanding challenge in the field of cardiac tissue engineering. Here, we introduce an approach to generate anisotropic cardiac myobundles using cell‐adhesive, synthetic, electrospun fibers and stem cell‐derived cardiac fibroblasts.
Maggie E. Jewett   +15 more
wiley   +1 more source

Alimentación estratégica de ovejas en invierno

open access: yes, 2003
Un número importante de establecimientos ubicados en el sur de la patagonia presentan un alto riesgo invernal. El objetivo del presente trabajo fue determinar el efecto de la alimentación de ovejas confinadas en invierno por emergencias climáticas; con ...
Culun, Victor Pascual   +3 more
core  

O patrimônio cultural do Centro Histórico de Florianópolis: um estudo do papel dos Museus Histórico de Santa Catarina e Victor Meirelles na preservação e produção da cultura [PDF]

open access: yes, 2004
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Engenharia de Produção.Este trabalho pretende abordar as relações entre a criação de museus e sua utilização como patrimônio cultural produtor de conhecimento.
Silva, Tathianni Cristini da
core  

Home - About - Disclaimer - Privacy