Results 121 to 130 of about 2,562,050 (291)

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

open access: yesAdvanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni   +17 more
wiley   +1 more source

Detecting Cognitive Decline and Dementia in Santa Cruz, Galápagos Islands, Ecuador. [PDF]

open access: yesCureus, 2020
Espinosa Del Pozo PH   +9 more
europepmc   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

open access: yesAdvanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou   +18 more
wiley   +1 more source

A PESCA REALIZADA NA COMUNIDADE DE PESCADORES ARTESANAIS DE SANTA CRUZ / ES - BRASIL

open access: yesBoletim do Instituto de Pesca, 2018
Localizada no estuário do rio Piraquê-açu, Santa Cruz í  ES, uma comunidade de pescadores artesanais foi alvo de um estudo realizado durante os anos 2000 e 2001.
Ricardo NETTO   +2 more
doaj  

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

open access: yesAdvanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang   +14 more
wiley   +1 more source

CALYPTOCEPHALELLA (ANURA, AUSTRALOBATRACHIA) REMAINS FROM RÍO SANTA CRUZ (EARLY–MIDDLE MIOCENE, SANTA CRUZ FORMATION), SANTA CRUZ PROVINCE, ARGENTINA

open access: yesPublicación Electrónica de la Asociación Paleontológica Argentina, 2019
In this contribution, the first anuran fossils from classical Santacrucian localities of the Río Santa Cruz are described. According to proportions and features recognized in the few skull elements recorded, the remains are assigned to the southern ...
Paula Muzzopappa
doaj  

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

open access: yesAdvanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi   +11 more
wiley   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

open access: yesAdvanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang   +6 more
wiley   +1 more source

Costo operativo de un equipo de labranza agrícola

open access: yes, 2003
En este trabajo se analiza el costo operativo de un equipo de labranza del CAP (Consejo Agrario Provincial). Se toma a este equipo como unidad de muestra ya que es uno de los equipos mas utilizados para realizar esta labor en Santa Cruz y en la ...
Claps, Leonardo
core   +1 more source

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