Advanced Science, EarlyView.In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu +12 more
wiley +1 more source
Exploratory assessment of the chemical and antioxidant potential of <i>Apis mellifera</i> honeys from Santa Cruz, Bolivia. [PDF]
Food Chem XLimpias-Hurtado JA +3 more
europepmc +1 more source
Advanced Science, EarlyView.Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang +7 more
wiley +1 more source
Changes in the consumption of immediate-release fentanyl between 2018 and 2022 in the province of Santa Cruz de Tenerife after the implementation of regulatory measures by health authorities. [PDF]
Naunyn Schmiedebergs Arch PharmacolPozuelo MR +5 more
europepmc +1 more source
Deconstruction of Human Age‐Related Cataract Capsules Defines Aging
Advanced Science, EarlyView.We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang +9 more
wiley +1 more source
Assessing the blood meal hosts of Culex quinquefasciatus and Aedes taeniorhynchus in Isla Santa Cruz, Galápagos. [PDF]
Parasit Vectors, 2019 Asigau S, Salah S, Parker PG.
europepmc +1 more source
CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer
Advanced Science, EarlyView.Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano +10 more
wiley +1 more source
Filipino Immigrants in Santa Cruz de Tenerife, Spain: Health and Access to Services. [PDF]
Healthcare (Basel)Parcon MG +3 more
europepmc +1 more source
Host phylogeny, diet, and habitat differentiate the gut microbiomes of Darwin's finches on Santa Cruz Island. [PDF]
Sci Rep, 2019 Loo WT +4 more
europepmc +1 more source
Advanced Science, EarlyView.A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal +5 more
wiley +1 more source