Results 11 to 20 of about 1,777 (137)

De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties. [PDF]

Adv Mater
NeoNectins are de novo‐designed miniproteins that selectively bind and stabilize the extended open form of integrin α5β1. When grafted onto biomaterials including hydrogel and titanium, they promote cell attachment and spreading in vitro and promoting tissue integration and bone growth in animal models, demonstrating broad potential for regenerative ...
Wang X, Guillem-Marti J, Kumar S, Lee DS, Cabrerizo-Aguado D, Werther R, Alamo KAE, Zhao YT, Nguyen A, Kopyeva I, Huang B, Li J, Hao Y, Li X, Brizuela-Velasco A, Murray A, Gerben S, Roy A, DeForest CA, Springer T, Ruohola-Baker H, Cooper JA, Campbell MG, Manero JM, Ginebra MP, Baker D.   +25 more
europepmc   +2 more sources

De Novo Design of High‐Affinity Miniprotein Binders Targeting Francisella Tularensis Virulence Factor

Angewandte Chemie, Volume 137, Issue 52, December 22, 2025.
Hybrid physics and deep‐learning enabled design methods identified miniprotein binders to Flpp3 (Francisella‐like lipoprotein), a key virulence factor from Francisella tularensis. Multiple candidates with nanomolar to picomolar binding affinities were obtained using yeast surface display screening and further experimental optimization.
Gizem Gokce‐Alpkilic, Buwei Huang, Andi Liu, Lieselotte S.M. Kreuk, Yaxi Wang, Victor Adebomi, Yensi Flores Bueso, Asim K. Bera, Alex Kang, Stacey R. Gerben, Stephen Rettie, Dionne K. Vafeados, Nicole Roullier, Inna Goreshnik, Xinting Li, David Baker, Joshua J. Woodward, Joseph D. Mougous, Gaurav Bhardwaj   +18 more
wiley   +2 more sources

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim, Tianxin Cao, Zhengpeng Wan, Jaesang Kim, Zhuxuan Li, Legairre A. Radden II, Rakesh Santhanam, Eunkyung Clare Ko, Tatsuya Osaki, Sarah Spitz, Hyunmin Moon, Maria Proestaki, Seokbeom Roh, Gyudo Lee, Jessie S. Jeon, Curtis R. Warren, Roger D. Kamm   +16 more
wiley   +1 more source

Oral herbal therapies for treating osteoarthritis (review) [PDF]

, 2014
Background Medicinal plant products are used orally for treating osteoarthritis. Although their mechanisms of action have not yet been elucidated in full detail, interactions with common inflammatory mediators provide a rationale for using them to ...
Cameron, Melainie, Chrubasik, Sigrun
core   +1 more source

The metric tide: report of the independent review of the role of metrics in research assessment and management [PDF]

, 2015
This report presents the findings and recommendations of the Independent Review of the Role of Metrics in Research Assessment and Management. The review was chaired by Professor James Wilsdon, supported by an independent and multidisciplinary group of ...
Allen, Liz, Belfiore, Eleonora, Campbell, Philip, Curry, Stephen, Hill, Jude, Hill, Steven, Johnson, Ben, Jones, Richard, Kain, Roger, Kerridge, Simon, Thelwall, Mike, Tinkler, Jane, Viney, Ian, Wilsdon, James, Wouters, Paul   +14 more
core   +3 more sources

Intracellular Detection of C. acnes and S. aureus in Non‐Herniated Human Intervertebral Discs: Implications for Catabolic Signaling Pathways

JOR SPINE, Volume 8, Issue 4, December 2025.
Cutibacterium acnes and Staphylococcus aureus antigens were detected within non‐herniated intervertebral discs and correlated with catabolic and pyroptotic markers (MMP‐3, GSDMD) and PRRs including NOD2. NP cells exposed to bacterial peptidoglycan showed MAPK/NF‐κB activation and catabolic cytokine release, suggesting that bacterial sensing through a ...
Andrea Nüesch, Exarchos Kanelis, Leonidas G. Alexopoulos, Benjamin Gantenbein, Melissa Lacey, Christine L. Le Maitre   +5 more
wiley   +1 more source

Voluntary Restriction or Freedom to Flourish? Self‐Regulation of Commercial Tutoring Providers for Managing Shadow Education

European Journal of Education, Volume 60, Issue 4, December 2025.
ABSTRACT Private tutoring, also called private supplementary education or shadow education, has experienced rapid growth in the past two decades. As the phenomenon has expanded globally, so too has the academic literature calling for understanding and effective governance of the sector.
Mohan Dhall
wiley   +1 more source

Identity Manipulation and Improvisatory Singing in Central Borneo [PDF]

, 2007
departmental bulletin ...
4615, Simeda, Takasi, シメダ, タカシ, 卜田, 隆嗣   +3 more
core   +1 more source

Mechanism and role of regulated cell death in tumor immunity and immunotherapy

Cancer Communications, Volume 45, Issue 11, Page 1456-1495, November 2025.
Abstract Cancer immune checkpoint inhibitors (ICIs) have brought breakthroughs, but only about one‐third of cancer patients benefit from ICIs. In recent years, targeting non‐apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis, has emerged as a novel strategy in cancer therapy due to ...
Jingwen Hu, Yan Li, Bingjie Lian, Yitao Mao, Luqing Zhao   +4 more
wiley   +1 more source

‘I Don't Think They've Ever Seen People Like Me Do Jobs Like This’: Exploring Hope Within Strengths‐Based Employment Services for People With Disability

Journal of Applied Research in Intellectual Disabilities, Volume 38, Issue 6, November 2025.
ABSTRACT Background Strengths‐based employment services focused on the abilities of people with intellectual disabilities challenge traditional, deficits‐based orientations. Within the presence of hope, which sustains collective effort toward a preferred future, such employment services may stimulate social change.
Kelly Carr‐Kirby, Sean Horton, Chad A. Sutherland, Victoria Paraschak, Patricia Weir   +4 more
wiley   +1 more source