Results 11 to 20 of about 136 (90)

De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties. [PDF]

Adv Mater
NeoNectins are de novo‐designed miniproteins that selectively bind and stabilize the extended open form of integrin α5β1. When grafted onto biomaterials including hydrogel and titanium, they promote cell attachment and spreading in vitro and promoting tissue integration and bone growth in animal models, demonstrating broad potential for regenerative ...
Wang X, Guillem-Marti J, Kumar S, Lee DS, Cabrerizo-Aguado D, Werther R, Alamo KAE, Zhao YT, Nguyen A, Kopyeva I, Huang B, Li J, Hao Y, Li X, Brizuela-Velasco A, Murray A, Gerben S, Roy A, DeForest CA, Springer T, Ruohola-Baker H, Cooper JA, Campbell MG, Manero JM, Ginebra MP, Baker D.   +25 more
europepmc   +2 more sources

De Novo Design of High‐Affinity Miniprotein Binders Targeting Francisella Tularensis Virulence Factor

Angewandte Chemie, Volume 137, Issue 52, December 22, 2025.
Hybrid physics and deep‐learning enabled design methods identified miniprotein binders to Flpp3 (Francisella‐like lipoprotein), a key virulence factor from Francisella tularensis. Multiple candidates with nanomolar to picomolar binding affinities were obtained using yeast surface display screening and further experimental optimization.
Gizem Gokce‐Alpkilic, Buwei Huang, Andi Liu, Lieselotte S.M. Kreuk, Yaxi Wang, Victor Adebomi, Yensi Flores Bueso, Asim K. Bera, Alex Kang, Stacey R. Gerben, Stephen Rettie, Dionne K. Vafeados, Nicole Roullier, Inna Goreshnik, Xinting Li, David Baker, Joshua J. Woodward, Joseph D. Mougous, Gaurav Bhardwaj   +18 more
wiley   +2 more sources

Natural History of Recurrent Acute Pancreatitis: Implications for Interventional Trial Design

Alimentary Pharmacology &Therapeutics, EarlyView.
In this nationwide cohort of 6894 patients with recurrent acute pancreatitis, recurrence risk increased progressively with each episode and occurred most frequently within the first year. Successive episodes were separated by shorter intervals, indicating an accelerating disease course and highlighting the importance of early preventive interventions ...
Søren S. Olesen, Niels Henrik Bruun, Line Davidsen, Srdan Novovic, Stig B. Laursen, Enrique de‐Madaria, Dhiraj Yadav, Asbjørn M. Drewes   +7 more
wiley   +1 more source

Kidney Transplant Recipients Develop Nasal Mucosal Antibodies to SARS‐CoV‐2 With ACE2‐Inhibiting Activity Following mRNA Vaccination

Transplant Infectious Disease, EarlyView.
Kidney transplant recipients develop nasal mucosal antibodies after systemic COVID‐19 vaccination, which are able to inhibit binding of SARS‐CoV‐2 to the ACE2 receptor, but at a lower concentration than the general population. ABSTRACT Background Less than 60% of kidney transplant recipients (KTRs) become IgG seropositive for the viral spike (S ...
Vera J. C. H. Koomen, Christa E. van der Gaast‐deJongh, Fred van Opzeeland, Ria Philipsen, Marije C. Baas, A. Lianne Messchendorp, Frederike J. Bemelman, Marcia M. L. Kho, Carla C. Baan, Debbie van Baarle, Jan‐Stephan F. Sanders, Rob van Binnendijk, Gerco den Hartog, Ron T. Gansevoort, Renate G. van der Molen, Luuk B. Hilbrands, Dimitri A. Diavatopoulos   +16 more
wiley   +1 more source

Dysphagia Screening in an Aging Population: A Scoping Review of Structural Gaps Between Triage and Comprehensive Evaluation in International and Japanese Practices

Journal of General and Family Medicine, Volume 27, Issue 4, July 2026.
ABSTRACT This scoping review aimed to map the characteristics of dysphagia screening implementation in published studies and to compare operational differences between non‐Japanese and Japanese practices, focusing on screening personnel, screening tools, and post‐screening management pathways.
Akihito Ueda, Kanji Nohara
wiley   +1 more source

EIGENSINN AND DOMINATION IN LIBERAL AND ILLIBERAL SOCIETIES

History and Theory, Volume 65, Issue 1, Page 32-57, March 2026.
ABSTRACT This article is a posthumously published text that was written by Alf Lüdtke and Alexandra Oeser but was left unfinished when Lüdtke died in February 2019. It examines two central notions—and their articulations—that Lüdtke and Oeser use differently in their work: domination and Eigensinn. On domination, it focuses on perspectives of Max Weber'
Alf Lüdtke, Alexandra Oeser
wiley   +1 more source

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim, Tianxin Cao, Zhengpeng Wan, Jaesang Kim, Zhuxuan Li, Legairre A. Radden II, Rakesh Santhanam, Eunkyung Clare Ko, Tatsuya Osaki, Sarah Spitz, Hyunmin Moon, Maria Proestaki, Seokbeom Roh, Gyudo Lee, Jessie S. Jeon, Curtis R. Warren, Roger D. Kamm   +16 more
wiley   +1 more source

Intracellular Detection of C. acnes and S. aureus in Non‐Herniated Human Intervertebral Discs: Implications for Catabolic Signaling Pathways

JOR SPINE, Volume 8, Issue 4, December 2025.
Cutibacterium acnes and Staphylococcus aureus antigens were detected within non‐herniated intervertebral discs and correlated with catabolic and pyroptotic markers (MMP‐3, GSDMD) and PRRs including NOD2. NP cells exposed to bacterial peptidoglycan showed MAPK/NF‐κB activation and catabolic cytokine release, suggesting that bacterial sensing through a ...
Andrea Nüesch, Exarchos Kanelis, Leonidas G. Alexopoulos, Benjamin Gantenbein, Melissa Lacey, Christine L. Le Maitre   +5 more
wiley   +1 more source

Voluntary Restriction or Freedom to Flourish? Self‐Regulation of Commercial Tutoring Providers for Managing Shadow Education

European Journal of Education, Volume 60, Issue 4, December 2025.
ABSTRACT Private tutoring, also called private supplementary education or shadow education, has experienced rapid growth in the past two decades. As the phenomenon has expanded globally, so too has the academic literature calling for understanding and effective governance of the sector.
Mohan Dhall
wiley   +1 more source

Mechanism and role of regulated cell death in tumor immunity and immunotherapy

Cancer Communications, Volume 45, Issue 11, Page 1456-1495, November 2025.
Abstract Cancer immune checkpoint inhibitors (ICIs) have brought breakthroughs, but only about one‐third of cancer patients benefit from ICIs. In recent years, targeting non‐apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis, has emerged as a novel strategy in cancer therapy due to ...
Jingwen Hu, Yan Li, Bingjie Lian, Yitao Mao, Luqing Zhao   +4 more
wiley   +1 more source