Results 141 to 150 of about 72,403 (303)

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Synthesis of a group of diosgenyl saponins by a one-pot sequential glycosylation

, 1999
A group of natural diosgenyl saponins was synthesized in a highly efficient manner employing the 'one-pot sequential glycosylation' protocol with the combined use of glycosyl trichloroacetimidates and thioglycosides. (C) 1999 Elsevier Science Ltd.
Han, XW, Hui, YZ, Yu, H, Yu, B
core  

From wild to tamed: Reimagining novel crops through omics and local plant diversity

PLANTS, PEOPLE, PLANET, EarlyView.
The global food system faces growing pressure from climate change, biodiversity loss, and rising nutritional demands. Agriculture has increased yields but reduced crop diversity, flavor, and nutritional quality, leaving societies vulnerable and dependent on a narrow set of staple species.
Alexandra Sanfeliu Meliá, Pablo D. Cárdenas   +1 more
wiley   +1 more source

Chemical diversity and phylogenetic insights into Hawaiian ʻākia (Wikstroemia) species used in traditional fishing practices

PLANTS, PEOPLE, PLANET, EarlyView.
Traditional fishing with plant‐based piscicides is a global practice in decline, facing increasing restrictions. We investigated the chemical diversity of endemic Wikstroemia species historically used to stun or poison fish in Hawaiʻi. Using 1‐H‐NMR, principal component analysis, targeted HPLC, and target‐capture sequencing, we characterized compounds ...
Louise Winther, Isaac Lichter‐Marck, Louise Kjaerulff, David Lorence, Uma Nagendra, Mike Opgenorth, Sverre J. Schou, Kenneth R. Wood, Felipe Zapata, Dan Staerk, Nina Rønsted   +10 more
wiley   +1 more source

Systematic Characterization of the In Vitro and In Vivo Chemical Constituents of Shenmai Formula by UHPLC-Orbitrap MS. [PDF]

Biomed Chromatogr
Wang X, Shen J, Qian J, Zhang S, Qiu H, Liu S, Hong M, Kou X, Shu L, Li Y.   +9 more
europepmc   +1 more source

A Scalable Large Language Model‐Aided Approach for Mining Plant‐Compound Pairs From Scientific Literature

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding plant chemicals is vital for medicine and agriculture, but global data remain fragmented and biased. We developed an AI‐powered tool to automatically extract plant‐compound information from scientific literature at scale and low cost. Our analysis revealed significant knowledge gaps, particularly in the Southern Hemisphere. By efficiently
Adam Richard‐Bollans, Francesco Civita
wiley   +1 more source

Behavioural manipulation of the cabbage stem flea beetle (Psylliodes chrysocephala L): Prospects for push–pull strategies in oilseed rape

Pest Management Science, EarlyView.
Behavioural manipulation of Psylliodes chrysocephala provides promising opportunities for sustainable pest management in oilseed rape systems. This review synthesises evidence on glucosinolates and their volatile isothiocyanate derivatives as phagostimulants and attractants, alongside the repellent or antifeedant effects of non‐host plants, plant ...
Suleiman Mustapha, Patricia A Ortega‐Ramos, Jozsef Vuts, Tariq M Butt, E. Joel Loveridge, Daniel Rüde, Samantha M Cook   +6 more
wiley   +1 more source

A formulation‐driven plant‐derived nanoemulsion for root‐knot nematode control in tomato: efficacy across pot and greenhouse conditions

Pest Management Science, EarlyView.
Plant‐derived nanoemulsion for root‐knot nematode control in tomato: formulation concept, proposed mode of action, and efficacy under pot and greenhouse conditions. Abstract Objective Nanoemulsion‐based delivery systems offer a promising approach to improve the stability and biological performance of plant‐derived nematicides.
Ramanan Ganapathy, Ahmet Aykaç
wiley   +1 more source

The characterization of a rhamnosylated triterpenic saponin from <i>Quillaja saponaria</i> Mol. reveals novel adjuvant, antibacterial, antiviral, antifungal and antiproliferative properties. [PDF]

Front Pharmacol
Bobadilla-Fazzini R, Marchant MJ, Grohmann E, Guzmán L, Padilla L.   +4 more
europepmc   +1 more source

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications

Phytotherapy Research, EarlyView.
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta, Sonalika Gupta, Gagandeep Kaur, Partha Sarathi Mondal, Milirani Das, Anagha Ranade, Alok Kumar Srivastava, Sachin Kumar, Manoj Kumar Barthwal, Madhu Dikshit   +9 more
wiley   +1 more source