<i>Polygonatum odoratum</i> (Mill.) Druce: A Review of Traditional Uses, Phytochemistry, Mass Spectrometric Fragmentation, Pharmacology, Toxicology, and Q-Marker Prediction. [PDF]
Drug Des Devel TherSun W +6 more
europepmc +1 more source
Yeast, EarlyView.Harnessing Brazilian microbial diversity, comprehensive phenotypic screening of 79 yeast isolates identified non‐conventional strains with superior multi‐stress tolerance and metabolic versatility compared to S. cerevisiae under industrially relevant conditions.
Giovanna R. Maklouf +10 more
wiley +1 more source
Matrine–Tea Saponin Synergism Involves Suppressed Detoxification and Digestion in a Leaf Beetle
Integrative Zoology, EarlyView.Tea saponin and matrine showed synergistic toxicity against Plagiodera versicolora. Combined exposure suppressed digestion‐ and detoxification‐related processes, while silencing the trypsin gene Pver105950 and chitinase gene Pver001190 increased larval susceptibility to tea saponin and matrine, respectively.
Owais Khan +4 more
wiley +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Systematic Characterization of the In Vitro and In Vivo Chemical Constituents of Shenmai Formula by UHPLC-Orbitrap MS. [PDF]
Biomed ChromatogrWang X +9 more
europepmc +1 more source
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
Plant-Derived Saponin and Polysaccharide Vaccine Adjuvants: Structure-Activity Relationships and Immune-Enhancement Strategies. [PDF]
Vaccines (Basel)Lao Y, Wang Z, Tian Y, Sun J, Gong L.
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu +9 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka +3 more
wiley +1 more source
Integrating metabolomic and transcriptomic analyses to identify candidate genes and transcriptional regulators associated with triterpenoid saponin accumulation in developing <i>Momordica charantia</i> fruits. [PDF]
Front Plant SciFan J +7 more
europepmc +1 more source