Integrated MALDI-MSI and UHPLC-OE-MS for Spatial Visualization and Biosynthetic Pathway Elucidation of Bioactive Metabolites in <i>Lilium lancifolium</i> Thunb. [PDF]
MoleculesDeng Q +7 more
europepmc +1 more source
MAIT Cells Suppress IgE‐Mediated Asthma via IFNγ‐Dependent B Cell Regulation
Allergy, EarlyView.In this study, we demonstrate that MAIT cell antagonism during sensitization and challenge with HDM worsens the development of airway hyperreactivity without effects on type 2 or 17 associated cytokine production or lung inflammation. Rather, MAIT cells appear to regulate HDM‐induced asthma through direct inhibition of IgE production.
Angela M. Cannata +6 more
wiley +1 more source
An activity labelled molecular networking strategy-assisted discovery of antiplatelet aggregation-active components from <i>Allium chinense</i> G. Don. [PDF]
Front NutrXu Y +8 more
europepmc +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Multifaceted therapeutic potential of saponins in type 2 diabetes mellitus: mechanisms targeting insulin resistance and diabetic complications. [PDF]
Front PharmacolYuan Y +7 more
europepmc +1 more source
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu +9 more
wiley +1 more source
Biocatalytic structural diversification of saponins in Zygophyllum decumbens: HR-LC-ESI-TOF-MS/MS profiling and bioactivity modulation. [PDF]
BMC Complement Med TherGabr NM +4 more
europepmc +1 more source
Coloration Technology, EarlyView.Abstract The instability of anthocyanins limits their application as natural food colorants. This study aimed to enhance the stability of anthocyanins extracted from Hibiscus sabdariffa through copigmentation with protein nanofibrils produced from pea, rice, gluten and whey isolates. Linear and curly nanofibril structures were prepared and incorporated
Vildan Eyiz +2 more
wiley +1 more source
Mitochondrial respiration and characteristics of skeletal muscles in children with cerebral palsy
Developmental Medicine &Child Neurology, EarlyView.Skeletal muscles utilize numerous mitochondria for energy production needed during muscle contraction. Mitochondria produce this energy through the electron transport chain. After an injury such as ACL‐injury in typically developing children, there is a reduction in muscle mitochondrial respiration and content.
Sudarshan Dayanidhi +10 more
wiley +1 more source