Dioscin Promotes Ferroptosis in Cervical Cancer Cells via the TIGAR‐ROS Axis
Dioscin suppresses cervical cancer progression by promoting ferroptosis. Mechanistically, Dioscin binds to TIGAR and inhibits TIGAR function, elevating ROS levels and inducing ferroptosis. ABSTRACT Cervical cancer seriously threatens women's life and health, highlighting the urgent need for targeted therapies.
Yameng Liu +6 more
wiley +1 more source
Abstract The instability of anthocyanins limits their application as natural food colorants. This study aimed to enhance the stability of anthocyanins extracted from Hibiscus sabdariffa through copigmentation with protein nanofibrils produced from pea, rice, gluten and whey isolates. Linear and curly nanofibril structures were prepared and incorporated
Vildan Eyiz +2 more
wiley +1 more source
The characterization of a rhamnosylated triterpenic saponin from <i>Quillaja saponaria</i> Mol. reveals novel adjuvant, antibacterial, antiviral, antifungal and antiproliferative properties. [PDF]
Bobadilla-Fazzini R +4 more
europepmc +1 more source
Mitochondrial respiration and characteristics of skeletal muscles in children with cerebral palsy
Skeletal muscles utilize numerous mitochondria for energy production needed during muscle contraction. Mitochondria produce this energy through the electron transport chain. After an injury such as ACL‐injury in typically developing children, there is a reduction in muscle mitochondrial respiration and content.
Sudarshan Dayanidhi +10 more
wiley +1 more source
Quinoa (<i>Chenopodium quinoa</i> Willd.) Saponins and Their Pharmaceutical Potential: A Review. [PDF]
Karydogianni S +7 more
europepmc +1 more source
Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini +4 more
wiley +1 more source
Extraction and spectroscopic characterization of polyphenol- and saponin-rich extracts from <i>musa balbisiana</i> corm with tentative identification of quercetin. [PDF]
Nhon HTN, Trang NTH, Anh LTH.
europepmc +1 more source
An SPF formulation incorporating Bixa orellana seed extracts and oils showed enhanced UV protection, highlighting the potential of natural bioactive compounds as effective boosters in photoprotective cosmetic products. Abstract Objective This study investigated the antioxidant activity of oil and alkaline aqueous extracts obtained from Bixa orellana ...
Ister Cordeiro Mariotini +8 more
wiley +1 more source
Machine learning for identifying antibacterial agents derived from yam (<i>Dioscorea</i>) and elucidating antibacterial mechanisms based on metabolomics. [PDF]
Ding J +9 more
europepmc +1 more source
STAG Priming Preserves Paneth Cells and Limits Parasite‐Triggered Ileitis
Preservation of Paneth cells is associated with resistance to ileitis caused by Toxoplasma gondii. ABSTRACT Toxoplasma gondii triggered ileitis is a commonly used model for diseases affecting the small intestine, such as Crohn's Disease. Inflammation is primarily dependent on Th1‐mediated killing of Paneth cells, which consequently promotes intestinal ...
Ester Cristina Borges Araujo +8 more
wiley +1 more source

