Results 191 to 200 of about 105,044 (309)

Catecholaminergic polymorphic ventricular tachycardia–linked ryanodine receptor variants exhibit domain‐specific calcium leak and calmodulin affinity properties

The Journal of Physiology, EarlyView.
Abstract figure legend Catecholaminergic polymorphic ventricular tachycardia (CPVT) variants in N terminal (NTD) and central domain (CD) but not pore domain induce a pathological RyR2 conformational shift upon protein kinase A (PKA) phosphorylation, similar to that seen in heart failure (HF), calcium/calmodulin‐dependent protein kinase II (CaMKII ...
Hitoshi Uchinoumi, Xiaoqiong Dong, Ivanita Stefanon, Yi Yang, Eduardo Hertel Ribeiro, Bengt Svensson, Xander H. T. Wehrens, Takeshi Yamamoto, Razvan L. Cornea, Robyn T. Rebbeck, Masafumi Yano, Donald M. Bers   +11 more
wiley   +1 more source

Diosgenin-mediated NF-κB and MAPK pathway modulation for osteoarthritis treatment: molecular mechanisms, bioavailability enhancement, and therapeutic applications. [PDF]

Inflammopharmacology
Adarkar R, Viswambharan VL, Dessai A, Lobo R, Tippavajhala VK, Pai V, Subraya CK, Aswatha Ram HN.   +7 more
europepmc   +1 more source

SAPONINS

Journal of Biological Chemistry, 1925
openaire   +1 more source

Mitochondrial physiology in cardiac muscle of deer mice native to high altitude

The Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude deer mice exhibited evolved changes in mitochondrial energy metabolism and reactive oxygen species (ROS) management that may support cardiac performance under cold hypoxic conditions. High‐altitude mice had increased activity of lactate dehydrogenase (LDH) in the heart, probably enhancing the capacity for lactate ...
Ranim Saleem, Samuel G. Robichaud, Simon G. Lamarre, Graham R. Scott   +3 more
wiley   +1 more source

Anticancer and antioxidant activities of Pelargonium graveolens L., Mentha longifolia L., and Chrysanthemum frutescens L. under salt stress. [PDF]

Sci Rep
Samy A, Helal NM, El-Araby MM, Abdallah WE.   +3 more
europepmc   +1 more source

Kikuba-saponin.(1).(Saponins of Japanese Dioscoreaceae. X.)

Chemical and Pharmaceutical Bulletin, 1962
T, KAWASAKI, T, YAMAUCHI, R, YAMAUCHI
openaire   +3 more sources

Advances in Eco‐Friendly Extraction of Fruit Bioactive Compounds: Technologies, Challenges and Future Directions

Analytical Science Advances, Volume 7, Issue 1, June 2026.
Fruit bioactive compounds offer antioxidant, anti‐inflammatory, and preventive benefits, yet extraction is hindered by poor solubility and conventional methods using toxic solvents and high energy. This review evaluates traditional and advanced eco‐friendly technologies, highlighting efficiency, selectivity, and sustainability.
Abadi Gebreyesus Hndeya, Desta Berhe Sbhatu, Gebreselema Gebreyohannes   +2 more
wiley   +1 more source

Integrated Orbitrap‐HRMS and Chemometric Profiling Reveals Metabolite Diversity and Antioxidant Signatures in Cerrado Eugenia Fruits

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Fruits from the Brazilian Cerrado, such as pitanga (Eugenia uniflora), jambolao (E. jambolana) and murta (E. punicifolia), are recognized for their nutritional and therapeutic potential, largely due to their phenolic‐rich profiles. However, systematic studies integrating high‐resolution mass spectrometry (HRMS) with chemometric tools to ...
Alexandre W. V. Nascimento, Naará S. Balbino, Salva Asghar, Erica A. Batista, Eric de Souza Gil, Abeer M. Alawi Al‐Sakkaf, Boniek G. Vaz, Teresinha J. A. S. Andrade, Nerilson Marques Lima   +8 more
wiley   +1 more source

Transcriptome and Metabolome Analyses Reveal Differences in the Accumulation of Key Metabolites in Various Tissues of Lonicera macranthoides. [PDF]

Metabolites
Li Z, Zhou Z, Qiu N, Yang F, Feng H, Li T, Hou Q.   +6 more
europepmc   +1 more source

Comparative Functionality and Processing of Plant‐Proteins: A Path Toward Optimized Sustainable Plant‐Based Meat Analogues (PBMAs): A Review

Sustainable Food Proteins, Volume 4, Issue 2, June 2026.
The review provides a comprehensive comparison in terms comparison of commercially established and emerging plant protein sources, focusing on their structural, rheological, and sensory attributes for developing sustainable plant‐based meat analogues (PBMAs).
Mian N. Riaz, Fariha Irshad, Muhammad Bilal Haider, Debomitra Dey   +3 more
wiley   +1 more source