Results 131 to 140 of about 131,690 (295)
British Journal of Clinical Pharmacology, EarlyView.Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić +7 more
wiley +1 more source
British Educational Research Journal, EarlyView.Abstract Recruiting and retaining school leaders is a challenge in many systems worldwide. Previous research has identified three distinct ways in which succession planning can be conceptualised and approached: a ‘pipeline’ approach seeks to match supply and demand for the posts that need filling; a ‘pool’ strategy involves proactively identifying and ...
Toby Greany +3 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Protein aggregation poses a significant risk to biopharmaceutical product quality, as even minor amounts of oligomeric species can compromise efficacy and safety. Rapid and reliable detection of protein aggregates thus remains a major challenge in biopharmaceutical manufacturing.
Jakob Heyer‐Müller +4 more
wiley +1 more source
Raman Spectroscopy–Based Glucose Feed Control Automates Malic Acid Fermentation
Biotechnology and Bioengineering, EarlyView.Raman spectroscopy enables automated, closed‐loop glucose feeding for malic acid production with Ustilago trichophora. Online PLS regression of glucose and malic acid provides input for PID control to maintain 20 g/L glucose. The feed is dynamically adjusted and stopped in response to metabolic demand and product inhibition, demonstrating practical ...
Luca Antonia Grebe +8 more
wiley +1 more source
Ultra‐High‐Efficiency On‐Chip CO2 Conversion by Nanosecond Self‐Pulsing Micro‐Plasma Devices
Carbon Energy, EarlyView.A micro‐plasma chip with sub‐10‐μm electrode gaps is introduced for efficient CO2‐to‐CO conversion. The device self‐converts a DC power supply into nanosecond pulses, producing field‐emission electrons that vibrationally excite CO2, driving dissociation via the ladder‐climbing mechanism. A scaled‐up chip array achieves 30% single‐pass conversion and 50%
Guangyu Sun +5 more
wiley +1 more source
Carbon Energy, EarlyView.Heterostructured interfaces can accelerate hydrogen evolution by improving water dissociation, yet their underlying mechanisms remain unclear. This study combines in situ Raman spectroscopy and density functional theory to reveal how the RuO2/TiO2 interface promotes both water dissociation and hydrogen adsorption, providing new insights into the ...
Dwi Sakti Aldianto Pratama +3 more
wiley +1 more source
Sodium Tetraazidoaurate(III)—From Na[AuCl4]·2H2O to Na[Au(N3)4] and Beyond One Step at a Time
Chemistry – A European Journal, EarlyView.Novel sodium chlorido‐/azidoaurate(III) dihydrates Na[AuCl4–x(N3)x]·2H2O (x = 0, 1, 2, 3, 4) provide the first example of a complete series of gradual substitution on tetramer complex anions to be described. Controlled dehydration of Na[Au(N3)4]·2H2O leads to Na[Au(N3)4]·H2O and Na[Au(N3)4], the latter being a highly explosive material.
Mehmet Somer +10 more
wiley +1 more source
Accessing Sn≥2 States of a TADF Emitter by Femtosecond NIR Spectroscopy
Chemistry – A European Journal, EarlyView.The depicted thermally activated delayed fluorescence (TADF) emitter was studied by femtosecond near‐infrared (NIR) spectroscopy. A prominent NIR transition was shown to be strongly solvent‐dependent, with implication for intersystem crossing in the compound.
Wiebke Haselbach +7 more
wiley +1 more source
ChemPhysChem, Volume 26, Issue 6, March 15, 2025.The correlation of a spectroscopic (EPRI) and microscopic (AFM) technique is demonstrated for a sample of Li deposited on Cu. Areas of different morphology were analysed. The techniques complement each other's length scales as well as the information obtained from the sample.
Beatrice Wolff +5 more
wiley +1 more source
Deep Underground Science and Engineering, EarlyView.Abstract As tunnel construction advances in lengths and depths, the construction of tunnels in high geothermal environments has become increasingly common, raising significant fire risks. In this study, a 1:20 scale model tunnel test platform was constructed to investigate the effects of a high geothermal environment on fire behavior in tunnels during ...
Xiaoxian Fei +6 more
wiley +1 more source