Results 21 to 30 of about 1,393 (127)

The pterin binding site of dihydropteroate synthase (DHPS): In silico screening and in vitro antibacterial activity of existing drugs

Results in Chemistry, 2023
Antimicrobial resistance has rendered the sulfonamide class of antibiotics obsolete. An additional binding site on the dihydropteroate synthase (DHPS) enzyme, i.e., the pterin binding site, has been shown to be a valid alternative to the well-known para ...
Maryké Shaw, Anél Petzer, Jacobus P. Petzer, Theunis T. Cloete   +3 more
doaj   +1 more source

Use of sapropterin in Mexican patients with yperphenylalaninemia

Acta Pediátrica de México, 2014
Hyperphenylalaninemia is caused by deficient enzyme activity of phenylalanine hydroxylase. It was one of the first genetic disorders susceptible to treatment with a natural protein restricted diet for life.
Susana Monroy-Santoyo, Leticia Belmont-Martínez, Cynthia Fernández-Lainez   +2 more
doaj   +1 more source

Structural And Phytochemical Characterization of Bioactive Components of the Endophytic Fungi (Trichoderma harzianum) Extracts

Journal of Applied Sciences and Environmental Management, 2022
This research aims to investigate the antioxidant activity of the crude extract of endophytic fungi (T. harzianum) and to test for the presence of phytochemicals. Fungi isolated from the leaf and stem of endemic medicinal plant were extracted with ethyl
O. M. Ameen, T. Garuba, M. F. Zubair, M. T. Baker, B. Z. Arowolo, A. O. Yakubu   +5 more
doaj   +1 more source

HPLC-Based Analysis of Impurities in Sapropterin Branded and Generic Tablets

Pharmaceutics, 2020
This work was aimed at the definition of a chromatographic method able to separate and quantify impurities present in sapropterin-containing drugs during an accelerated stability study. The chromatographic method was applied to the orphan drug Kuvan® and
Emanuela Scudellaro, Luciana Tartaglione, Fabio Varriale, Carmela Dell’Aversano, Orazio Taglialatela-Scafati   +4 more
doaj   +1 more source

Sapropterin dihydrochloride therapy in dihydropteridine reductase deficiency: Insight from the first case with molecular diagnosis in Brazil

JIMD Reports, 2021
Tetrahydrobiopterin (BH4) is a cofactor that participates in the biogenesis reactions of a variety of biomolecules, including l‐tyrosine, l‐3,4‐dihydroxyphenylalanine, 5‐hydroxytryptophan, nitric oxide, and glycerol.
Charles Marques Lourenço, Janaina Dovidio, Isabela F. Lopes, Laís C. Silva, Marcela Almeida, Laura Vagnini, Jacqueline Fonseca, Zumira A. Carneiro, Beat Thöny   +8 more
doaj   +1 more source

Italian national consensus statement on management and pharmacological treatment of phenylketonuria

Orphanet Journal of Rare Diseases, 2021
Background Phenylketonuria (PKU) is a rare inherited metabolic disorder caused by defects in the phenylalanine-hydroxylase gene (PAH), the enzyme catalyzing the conversion of phenylalanine to tyrosine.
Alberto Burlina, Giacomo Biasucci, Maria Teresa Carbone, Chiara Cazzorla, Sabrina Paci, Francesca Pochiero, Marco Spada, Albina Tummolo, Juri Zuvadelli, Vincenzo Leuzzi   +9 more
doaj   +1 more source

First Japanese case of maternal phenylketonuria treated with sapropterin dihydrochloride and the normal growth and development of the child

Molecular Genetics and Metabolism Reports, 2019
Sapropterin dihydrochloride (SD) may be a new treatment option for women with phenylketonuria (PKU) who plan to become pregnant. We report the first Japanese case of maternal PKU treated with SD.
Hiromi Nyuzuki, Taro Yamazaki, Megumi Saito, Akira Ohtake   +3 more
doaj   +1 more source

Integrated genomic network analysis revealed potential of a druggable target for hemorrhoid treatment

Saudi Pharmaceutical Journal, 2023
Hemorrhoids are a prevalent medical condition that necessitates effective treatment options. The current options for treatment consist of oral medications, topical applications, or surgery, yet a scarcity of highly effective drugs still exists.
Wirawan Adikusuma, Firdayani Firdayani, Lalu Muhammad Irham, Darmawi Darmawi, Muhammad Yulis Hamidy, Baiq Leny Nopitasari, Soraya Soraya, Nurul Azizah   +7 more
doaj   +1 more source

Phenylketonuria: nutritional advances and challenges

Nutrition & Metabolism, 2012
Despite the appearance of new treatment, dietary approach remains the mainstay of PKU therapy. The nutritional management has become complex to optimize PKU patients' growth, development and diet compliance.
Giovannini Marcello, Verduci Elvira, Salvatici Elisabetta, Paci Sabrina, Riva Enrica   +4 more
doaj   +1 more source

Diagnostic and therapeutic recommendations for the treatment of hyperphenylalaninemia in patients 0–4 years of age

Orphanet Journal of Rare Diseases, 2018
Background Treatment of phenylketonuria (PKU) with sapropterin dihydrochloride in responsive patients from an early age can have many advantages for the patient over dietary restriction alone.
Ania C. Muntau, Marcel du Moulin, Francois Feillet   +2 more
doaj   +1 more source