Endogenous tetrahydrobiopterin in humans: circadian rhythm, sex, race, age, and disease status [PDF]
Frontiers in PharmacologyIntroduction6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for multiple enzymes, including phenylalanine hydroxylase (PAH). Exogenous BH4, or its natural precursor sepiapterin, is utilized to treat patients with phenylketonuria ...
Lan Gao, Neil Smith, Ronald Kong
doaj +2 more sources
Preparation and Characterization of Ti(BH4)3(THF)3 and V(BH4)2(TMEDA)2 Complexes [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 1994 We have recently synthesized Ti(BH4)3(THF)3 and V(BH4)2(TMEDA)2 complexes. The reaction of TiCl3(THF)3 with NaBH4 in dry THF gave flat blue crystals, Ti(BH4)3(THF)3. The reaction of VCl3 with NaBH4 in presence of N, N, N', N'- tetramethylethylenediamine,
Hossein Aghabozorg, Robabeh Alizadeh
doaj +1 more source
Tetrahydrobiopterin enhances regulatory T- and mast cell proliferation and alters cytokines expression in a murine heart transplant model [PDF]
Scientific ReportsAdministration of tetrahydrobiopterin (BH4) has been shown to attenuate acute allograft rejection in a murine heart transplantation model in a manner similar to that of cyclosporine A.
Susanne Ebner +17 more
doaj +2 more sources
Artemisinin alleviates Parkinson’s disease by targeting Adcy5-Gch1 axis to trigger a cascade generation of BH4 and dopamine in rats [PDF]
Genome BiologyBackground Parkinson’s disease is a highly prevalent neurodegenerative disorder. Hyposecretion of dopamine (DA) is the end result in the pathology of Parkinson’s disease. Unfortunately, safe and efficient therapeutic drugs are deficient.
Xin-xing Yang +5 more
doaj +2 more sources
Antioxidants, 2022 Tetrahydrobiopterin (BH4) is an essential cofactor of all nitric oxide synthase isoforms, thus determination of BH4 levels can provide important mechanistic insight into diseases.
Ksenija Vujacic-Mirski +8 more
doaj +1 more source
Current Pharmaceutical Biotechnology, 2011 Understanding and consequently treating neuropathic pain effectively is a challenge for modern medicine, as unlike inflammation, which can be controlled relatively well, chronic pain due to nerve injury is refractory to most current therapeutics. Here we define a target pathway for a new class of analgesics, tetrahydrobiopterin (BH4) synthesis and ...
Alban, Latremoliere, Michael, Costigan
openaire +2 more sources
The Critical Role of Tetrahydrobiopterin (BH4) Metabolism in Modulating Radiosensitivity: BH4/NOS Axis as an Angel or a Devil [PDF]
Frontiers in Oncology, 2021 Ionizing radiation and radioactive materials have been widely used in industry, medicine, science and military. The efficacy of radiotherapy and adverse effects of normal tissues are closed related to cellular radiosensitivity. Molecular mechanisms underlying radiosensitivity are of significance to tumor cell radiosensitization as well as normal tissue
Yang Feng +7 more
openaire +3 more sources
Tetrahydrobiopterin Supplementation: Elevation of Tissue Biopterin Levels Accompanied by a Relative Increase in Dihydrobiopterin in the Blood and the Role of Probenecid-Sensitive Uptake in Scavenging Dihydrobiopterin in the Liver and Kidney of Rats. [PDF]
PLoS ONE, 2016 Tetrahydrobiopterin (BH4) is an essential cofactor of nitric oxide synthase (NOS) and aromatic amino acid hydroxylases. BH4 and 7,8-dihydrobiopterin (BH2) are metabolically interchangeable at the expense of NADPH.
Akiko Ohashi +6 more
doaj +1 more source
BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes
Life Science Alliance, 2020 This study reports that BH4 activates CaMKK2/PGC-1α; signaling pathway and has a therapeutic effect on diabetic cardiomyopathy. Diabetic cardiomyopathy (DCM) is a major cause of mortality/morbidity in diabetes mellitus patients.
Hyoung Kyu Kim +24 more
doaj +1 more source
Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice [PDF]
Neurotherapeutics, 2021 Depletion of the enzyme cofactor, tetrahydrobiopterin (BH4), in T-cells was shown to prevent their proliferation upon receptor stimulation in models of allergic inflammation in mice, suggesting that BH4 drives autoimmunity. Hence, the clinically available BH4 drug (sapropterin) might increase the risk of autoimmune diseases.
Katja Schmitz +13 more
openaire +3 more sources