Results 1 to 10 of about 18,118 (168)
BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes
Life Science Alliance, 2020 This study reports that BH4 activates CaMKK2/PGC-1α; signaling pathway and has a therapeutic effect on diabetic cardiomyopathy. Diabetic cardiomyopathy (DCM) is a major cause of mortality/morbidity in diabetes mellitus patients.
Hyoung Kyu Kim +24 more
doaj +2 more sources
Frontiers in Cell and Developmental Biology, 2022 Ferroptosis, a type of cell death triggered by excessive accumulation of iron-dependent lipid peroxidation, possesses an excellent potential in cancer treatment.
Qian Hu +10 more
semanticscholar +1 more source
The Competition between 4-Nitrophenol Reduction and BH4− Hydrolysis on Metal Nanoparticle Catalysts
Molecules, 2023 Assessing competitive environmental catalytic reduction processes via NaBH4 is essential, as BH4− is both an energy carrier (as H2) and a reducing agent. A comprehensive catalytic study of the competition between the borohydride hydrolysis reaction (BHR,
S. Varshney +3 more
semanticscholar +1 more source
Science Translational Medicine, 2022 Increased tetrahydrobiopterin (BH4) generated in injured sensory neurons contributes to increased pain sensitivity and its persistence. GTP cyclohydrolase 1 (GCH1) is the rate-limiting enzyme in the de novo BH4 synthetic pathway, and human single ...
Shane J.F. Cronin +18 more
semanticscholar +1 more source
Antioxidants, 2022 Tetrahydrobiopterin (BH4) is an essential cofactor of all nitric oxide synthase isoforms, thus determination of BH4 levels can provide important mechanistic insight into diseases.
Ksenija Vujacic-Mirski +8 more
doaj +1 more source
Chemosphere, 2021 Anode biofilm thickness is a key point for high and sustainable power generation in microbial fuel cells (MFCs). Over time, the formation of a thicker biofilm on anode electrode hinders the power generation performance of MFC by causing a longer electron
Banu Taşkan, E. Taşkan
semanticscholar +1 more source
The Nrf2/GCH1/BH4 Axis Ameliorates Radiation-Induced Skin Injury by Modulating the ROS Cascade
Journal of Investigative Dermatology, 2017 Wei-Qun Ding, Peng Cao, Jundong Zhou
exaly +2 more sources
International Journal of Molecular Sciences, 2021 Cancer development is associated with abnormal proliferation, genetic instability, cell death resistance, metabolic reprogramming, immunity evasion, and metastasis.
Diego Assis Gonçalves +2 more
semanticscholar +1 more source
Frontiers in Oncology, 2021 Ionizing radiation and radioactive materials have been widely used in industry, medicine, science and military. The efficacy of radiotherapy and adverse effects of normal tissues are closed related to cellular radiosensitivity.
Yang Feng +5 more
semanticscholar +1 more source
Consensus guideline for the diagnosis and treatment of tetrahydrobiopterin (BH4) deficiencies
Orphanet Journal of Rare Diseases, 2020 Tetrahydrobiopterin (BH4) deficiencies comprise a group of six rare neurometabolic disorders characterized by insufficient synthesis of the monoamine neurotransmitters dopamine and serotonin due to a disturbance of BH4 biosynthesis or recycling ...
T. Opladen +29 more
semanticscholar +1 more source