Results 21 to 30 of about 22,851 (287)
Nutrients, 2021 The traditional treatment for phenylketonuria (PKU) is a phenylalanine (Phe)-restricted diet, supplemented with a Phe-free/low-Phe protein substitute. Pharmaceutical treatment with synthetic tetrahydrobiopterin (BH4), an enzyme cofactor, allows a patient
Fatma Ilgaz +8 more
semanticscholar +1 more source
Novel solvates M(BH4)3S(CH3)2 and properties of halide-free M(BH4)3 (M = Y or Gd) [PDF]
, 2014 Rare earth metal borohydrides have been proposed as materials for solid-state hydrogen storage because of their reasonably low temperature of decomposition.
Buckley, Craig +12 more
core +2 more sources
Tetrahydrobiopterin Supplementation: Elevation of Tissue Biopterin Levels Accompanied by a Relative Increase in Dihydrobiopterin in the Blood and the Role of Probenecid-Sensitive Uptake in Scavenging Dihydrobiopterin in the Liver and Kidney of Rats. [PDF]
PLoS ONE, 2016 Tetrahydrobiopterin (BH4) is an essential cofactor of nitric oxide synthase (NOS) and aromatic amino acid hydroxylases. BH4 and 7,8-dihydrobiopterin (BH2) are metabolically interchangeable at the expense of NADPH.
Akiko Ohashi +6 more
doaj +1 more source
Enhanced hydrogen storage properties of NaBH4–Mg(BH4)2 composites by NdF3 addition
Progress in Natural Science: Materials International, 2021 As two important members of complex hydrides, Mg(BH4)2 and NaBH4 have a high gravimetric capacity (14.9 and 10.8 wt%, respectively). In this study, the Mg(BH4)2 was synthesized by the ion exchange method.
Jian-Guang Yuan +8 more
semanticscholar +1 more source
Journal of Power Sources, 2020 The push towards the development of next-generation solid-state batteries has motivated the search for novel solid electrolyte materials. Sodium antiperovskites represent a structural family of ion conductors that has emerged as a result, with expected ...
Ernest Ahiavi +7 more
semanticscholar +1 more source
Central tetrahydrobiopterin concentration in neurodevelopmental disorders
Frontiers in Neuroscience, 2010 Tetrahydrobiopterin (BH4) is a naturally occurring cofactor essential for critical metabolic pathways. Studies suggest that BH4 supplementation may ameliorate autism symptoms; the biological mechanism for such an effect is unknown.
Richard E Frye
doaj +1 more source
Oxidative Stress and Pteridines in Pediatric Asthma: Relationship to Exhaled Nitric Oxide
Pteridines, 2012 Fractional exhaled nitric oxide (FeNO) is a useful marker of airway inflammation in asthmatics. Nitric oxide synthase (NOS) requires tetrahydrobiopterin as a cofactor and produces superoxide during NO generation.
Takeda Taisuke +5 more
doaj +1 more source
Pteridines, 2002 The effect of the intracellular 5,6,7,8-tetrahydrobiopterin (BH4) on the increased γ-glutamylcysteine synthetase (γ-GCS) mRNA expression induced by nitric oxide (NO) was investigated in RAW264.7 cells.
Kojima Shuji +2 more
doaj +1 more source
Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice [PDF]
Neurotherapeutics, 2021 Depletion of the enzyme cofactor, tetrahydrobiopterin (BH4), in T-cells was shown to prevent their proliferation upon receptor stimulation in models of allergic inflammation in mice, suggesting that BH4 drives autoimmunity. Hence, the clinically available BH4 drug (sapropterin) might increase the risk of autoimmune diseases.
Katja Schmitz +13 more
openaire +3 more sources
Functional analysis of sepiapterin reductase in Drosophila melanogaster
Pteridines, 2015 Sepiapterin reductase (SR) is a key enzyme involved in the biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for the synthesis of important biogenic amines, including catecholamines and serotonin.
Kim Kiyoung, Kim Heuijong, Yim Jeongbin
doaj +1 more source