Results 11 to 20 of about 10,809 (188)

Central tetrahydrobiopterin concentration in neurodevelopmental disorders

Frontiers in Neuroscience, 2010
Tetrahydrobiopterin (BH4) is a naturally occurring cofactor essential for critical metabolic pathways. Studies suggest that BH4 supplementation may ameliorate autism symptoms; the biological mechanism for such an effect is unknown.
Richard E Frye
doaj   +1 more source

Functional analysis of sepiapterin reductase in Drosophila melanogaster

Pteridines, 2015
Sepiapterin reductase (SR) is a key enzyme involved in the biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for the synthesis of important biogenic amines, including catecholamines and serotonin.
Kim Kiyoung, Kim Heuijong, Yim Jeongbin
doaj   +1 more source

Theoretical and experimental study on Mg(BH4)2–Zn(BH4)2 mixed borohydrides [PDF]

Journal of Alloys and Compounds, 2013
Abstract After a screening of possible systems prone to give an enthalpy of decomposition close to 30 kJ mol H 2 - 1 , i.e. suitable for a dehydrogenation process close to room temperature and pressure, the Zn dissolution into Mg(BH4)2 has been investigated.
ALBANESE, ELISA, G. Kalantzopoulos, VITILLO, Jenny Grazia, PINATEL, EUGENIO RICCARDO, CIVALLERI, Bartolomeo, S. Deledda, BORDIGA, Silvia, B. Hauback, BARICCO, Marcello   +8 more
openaire   +3 more sources

Oxidative Stress and Pteridines in Pediatric Asthma: Relationship to Exhaled Nitric Oxide

Pteridines, 2012
Fractional exhaled nitric oxide (FeNO) is a useful marker of airway inflammation in asthmatics. Nitric oxide synthase (NOS) requires tetrahydrobiopterin as a cofactor and produces superoxide during NO generation.
Takeda Taisuke, Hamazaki Takashi, Wakahara Ryohei, Fujioka Hiroki, Niihira Shizuhiro, Shintaku Haruo   +5 more
doaj   +1 more source

A New Functional Role of 5,6,7,8-tetrahydrobiopterin (BH4) as an Inhibitor of γ-glutamylcysteine Synthetase (γ-GCS) mRNA Expression

Pteridines, 2002
The effect of the intracellular 5,6,7,8-tetrahydrobiopterin (BH4) on the increased γ-glutamylcysteine synthetase (γ-GCS) mRNA expression induced by nitric oxide (NO) was investigated in RAW264.7 cells.
Kojima Shuji, Kurozumi Risa, Tuchiya Maiko   +2 more
doaj   +1 more source

Treatment With Tetrahydrobiopterin Improves White Matter Maturation in a Mouse Model for Prenatal Hypoxia in Congenital Heart Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Reduced oxygen delivery in congenital heart disease causes delayed brain maturation and white matter abnormalities in utero. No treatment currently exists. Tetrahydrobiopterin (BH4) is a cofactor for neuronal nitric oxide synthase.
Jennifer Romanowicz, Camille Leonetti, Zaenab Dhari, Ludmila Korotcova, Shruti D. Ramachandra, Nemanja Saric, Paul D. Morton, Shivani Bansal, Amrita Cheema, Vittorio Gallo, Richard A. Jonas, Nobuyuki Ishibashi   +11 more
doaj   +1 more source

Tetrahydrobiopterin: Beyond Its Traditional Role as a Cofactor

Antioxidants, 2023
Tetrahydrobiopterin (BH4) is an endogenous cofactor for some enzymatic conversions of essential biomolecules, including nitric oxide, and monoamine neurotransmitters, and for the metabolism of phenylalanine and lipid esters.
Tuany Eichwald, Lucila de Bortoli da Silva, Ananda Christina Staats Pires, Laís Niero, Erick Schnorrenberger, Clovis Colpani Filho, Gisele Espíndola, Wei-Lin Huang, Gilles J. Guillemin, José E. Abdenur, Alexandra Latini   +10 more
doaj   +1 more source

Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia–reperfusion injury

Experimental Physiology, 2023
Tetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide (NO) synthases in which its production of NO is crucial for cardiac function.
Sandy M. Chu, Lisa C. Heather, Surawee Chuaiphichai, Thomas Nicol, Benjamin Wright, Matthieu Miossec, Jennifer K. Bendall, Gillian Douglas, Mark J. Crabtree, Keith M. Channon   +9 more
doaj   +1 more source

Hydrogen Peroxide Stimulates the LPS-induced Tetrahydrobiopterin Synthesis in Mouse Brain Microvascular Endothelial Cells

Pteridines, 2002
Tetrahydrobiopterin (BH4) is one of the cofactors for nitric oxide synthase (NOS), and also has a protective effect against reactive oxygen species (ROS)- and/or nitric oxide (NO)-induced cytotoxicities. Lipopolysaccharide (LPS) induces NO production and
Shiota Kazuhiro, Shimizu Shumchi, Ishii Masakazu, Yamamoto Shinichiro, Iwasaki Michiko, Yamamoto Toshinori, Kiuchi Yuji   +6 more
doaj   +1 more source

The challenge of long-term tetrahydrobiopterin (BH4) therapy in phenylketonuria: Effects on metabolic control, nutritional habits and nutrient supply

Molecular Genetics and Metabolism Reports, 2015
Background and aims: BH4-sensitive phenylketonuria (PKU) patients relax their phenylalanine (Phe) restricted diet due to increased Phe tolerance, while keeping dried blood Phe concentrations with in the therapeutic range.
Alena G. Thiele, Carmen Rohde, Ulrike Mütze, Maria Arelin, Uta Ceglarek, Joachim Thiery, Christoph Baerwald, Wieland Kiess, Skadi Beblo   +8 more
doaj   +1 more source