Results 41 to 50 of about 22,851 (287)

The first European guidelines on phenylketonuria: Usefulness and implications for BH4 responsiveness testing

Journal of Inherited Metabolic Disease, 2020
This study aimed to investigate and improve the usefulness of the 48‐hour BH4 loading test and to assess genotype for BH4 responsiveness prediction, using the new definition of BH4 responsiveness from the European guidelines, as well as an amended ...
R. Evers, Annemiek M. J. Wegberg, K. Anjema, C. Lubout, E. Dam, D. Vliet, N. Blau, F. Spronsen   +7 more
semanticscholar   +1 more source

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

Insulin Secretion in Response to L-Arginine under Decreasing Tetrahydrobiopterin Content

Pteridines, 2008
Tetrahydrobiopterin (BH4) content in the pancreas from GK (Goto-Kakizaki) rats as a type II diabetic model was markedly decreased compared to Wistar rats as a healthy control. Moreover, insulin stimulated BH4 synthesis in a hamster pancreatic β-cell line,
Ishii Masakazu, Shimizu Shunichi, Watabe Tatsuya, Kiuchi Yuji   +3 more
doaj   +1 more source

Inhibition of Ferroptosis by Mesenchymal Stem Cell-Derived Exosomes in Acute Spinal Cord Injury: Role of Nrf2/GCH1/BH4 Axis

Neurospine
Objective The therapeutic benefits of exosomes obtained from mesenchymal stem cells (MSCs) in acute spinal cord injury (SCI) have been demonstrated in recent years, but the precise mechanisms remain unknown.
Yixin Chen, Bing-Fa Li, Jing Quan, Zhe Li, Yan Li, Yin-Bo Tang   +5 more
semanticscholar   +1 more source

Ammine Lanthanum and Cerium Borohydrides, M(BH4)3·nNH3; Trends in Synthesis, Structures, and Thermal Properties.

Inorganic Chemistry, 2020
Ammine metal borohydrides show potential for solid-state hydrogen storage and can be tailored toward hydrogen release at low temperatures. Here, we report the synthesis and structural characterization of seven new ammine metal borohydrides, M(BH4)3·nNH3,
J. B. Grinderslev, M. Ley, Young-Su Lee, Lars H. Jepsen, Mathias Jørgensen, Y. Cho, J. Skibsted, T. Jensen   +7 more
semanticscholar   +1 more source

Double Reduction of Ph3B to a Dianionic Borane With a Powerful SrI Intermediate

Angewandte Chemie, EarlyView.
Although dianionic boranes follow the octet rule and are isoelectronic to carbanions or amines, the high electron density combined with the electropositive nature of the B center make them highly unstable species. In this study, we present synthesis and full characterization of a complex in which Ph3B2− is sandwiched between two Sr2+ ions and describe ...
Michael Morasch, Marcel A. Schmidt, Tanuja Tewari, Jens Langer, Sjoerd Harder   +4 more
wiley   +2 more sources

Differential Inhibition of Constitutive and Inducible Nitric Oxide Synthase in Vascular Endothelial Cells by Analogues of Tetrahydrobiopterin

Pteridines, 2002
In the vasculature, a physiologic production of nitric oxide (NO) is maintained by endothelial nitric oxide synthase (eNOS). Induction of inducible nitric oxide synthase (ÍNOS) under inflammatory conditions (e.g. septic shock) resulting in high levels of
Mueller Nicolas J, Walter Roland Β, Linscheid Philippe, Schaffner Andreas, Schoedon Gabriele   +4 more
doaj   +1 more source

Novel alkali earth borohydride Sr(BH4)2 and borohydride-chloride Sr(BH4)Cl.

, 2013
Two novel alkali earth borohydrides, Sr(BH4)2 and Sr(BH4)Cl, have been synthesized and investigated by in-situ synchrotron radiation powder X-ray diffraction (SR-PXD) and Raman spectroscopy.
Ravnsbæk, DB, Olesen, CH, Edwards, P. P., Ravnsbaek, D.B., Černý, R, Edwards, Peter, Ravnsbæk, D. B., Cerny, Radovan, Filinchuk, Y, Nickels, E. A., David, W.I.F., David, W. I. F., Cerny, R., Nickels, EA, Filinchuk, Yaroslav, Jensen, T.R., Olesen, C.H., Edwards, P.P., Jensen, T. R., David, WI, Nickels, E.A., Olesen, C. H., Jensen, TR, Ravnsbæk DB, Olesen CH, Nickels EA, Edwards PP, Filinchuk Y, David WIF, Cerny R, Jensen TR   +30 more
core   +1 more source

Challenges in the synthetic routes to Mn(BH4)2: Insight into intermediate compounds [PDF]

, 2015
We have studied the reaction of MnCl2 with MBH4 (M = Li+, Na+, K+) in Et2O. Crystal structures of two new intermediates, named [{M(Et2O)2}Mn2(BH4)5] (M = Li+, Na+), were elucidated by X-ray diffraction.
Tumanov, Nikolay, Filinchuk, Yaroslav, Jensen, Torben R., Safin, Damir, Zbigniew, Lodziana, Garcia, Yann, Richter, Bo   +6 more
core   +1 more source

Agostic Hydridoborate Complexes as Masked Coinage‐Metal Hydrides: Hydride Migration Between Boron and Gold Unlocks CO2 Reactivity

Angewandte Chemie, EarlyView.
Hydride addition to coinage‐metal diphosphine–borane complexes gives unprecedented Cu(I), Ag(I), and Au(I) hydridoborates featuring agostic σ(B–H)→M interactions. While, Cu and Ag derivatives are inert toward CO2, the Au analogue reversibly fixes CO2 and catalyzes its hydroboration as well as formic acid dehydrogenation through a cooperative B─H─Au ...
Balakrishna Peddi, Sonia Mallet‐Ladeira, Karinne Miqueu, Ghenwa Bouhadir, Didier Bourissou   +4 more
wiley   +2 more sources