Results 41 to 50 of about 10,809 (188)

Peripheralized sepiapterin reductase inhibition as a safe analgesic therapy

Frontiers in Pharmacology, 2023
The development of novel analgesics for chronic pain in the last 2 decades has proven virtually intractable, typically failing due to lack of efficacy and dose-limiting side effects.
Shane J. F. Cronin, Nick A. Andrews, Alban Latremoliere   +2 more
doaj   +1 more source

BH4 treatment in BH4-responsive PKU patients: preliminary data on blood prolactin concentrations suggest increased cerebral dopamine concentrations

Molecular Genetics and Metabolism, 2015
In phenylketonuria (PKU), cerebral neurotransmitter deficiencies have been suggested to contribute to brain dysfunction. Present treatment aims to reduce blood phenylalanine concentrations by a phenylalanine-restricted diet, while in some patients blood phenylalanine concentrations also respond to cofactor treatment with tetrahydrobiopterin (BH4 ...
van Vliet, Danique, Anjema, Karen, Jahja, Rianne, de Groot, Martijn J, Liemburg, Geertje B, Heiner-Fokkema, Rebecca, van der Zee, Eddy A, Derks, Terry G J, Kema, Ido P, van Spronsen, Francjan J   +9 more
openaire   +3 more sources

TAT‐BH4 counteracts Aβ toxicity on capillary endothelium [PDF]

FEBS Letters, 2007
Oxidative stress is one of the factor contributing to blood brain barrier degeneration. This phenomenon is observed during pathological conditions such as Alzheimer's disease or cerebral amyloid angiopathy in which brain haemorrhages are very frequent.
CANTARA, SILVIA, THORPE PE, ZICHE, MARINA, DONNINI, SANDRA   +3 more
openaire   +5 more sources

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Beneficial Role of Tetrahydrobiopterin on Various Cardiovascular Diseases and Regulation of its Levels under Pathological Conditions

Pteridines, 2006
5,6,7,8-Tetrahydrobiopterin (BH4) is an csscntial cofactor for production of nitric oxide (NO) by N O synthase (NOS). Nitric oxide (NO) is an important signaling mo!ecu!e for the regulation o f vita! functions such as vascular tone, neurotransmission and
Shimizu Shunichi, Ishii Masakazu, Wajima Teruaki, Hagiwara Tamio, Negoro Takaharu   +4 more
doaj   +1 more source

Effect of Decreased Levels of Intrinsic Tetrahydrobiopterin on Endothelial Function in Anesthetized Rats

Journal of Pharmacological Sciences, 2008
Tetrahydrobiopterin (BH4) deficiency has been suggested to be an important factor in vascular endothelial dysfunction. In this study, we investigated the influence of decreased BH4 level produced by administration of 2,4-diamino-6-hydroxypyrimidine (DAHP)
Naobumi Hamadate, Katsuhiko Noguchi, Mayuko Sakanashi, Toshihiro Matsuzaki, Junko Nakasone, Matao Sakanashi   +5 more
doaj   +1 more source

Multifunctional Design of Solid Polymer Electrolytes: Paving the Way for High‐Performance All‐Solid‐State Batteries

Carbon Energy, EarlyView.
This review provides a comprehensive and systematic overview of the multifunctional design strategies for solid polymer electrolytes (SPEs), a pivotal component for enabling high‐performance all‐solid‐state batteries (ASSBs). It begins with a detailed classification of SPE systems and elaborates on their respective molecular design principles. The work
Bin Man, Yuzhen Zhao, Bo Fu, Yulong Zeng, Yinwen Chen, Qingrui Liu, Wenjing Luo, Xin Li, Xuewei Li, Zikang Zhang, Yun Zheng, Sijie Liu   +11 more
wiley   +1 more source

Tetrahydrobiopterin Regulates L-tyrosine-induced Elevation of Cytosolic Calcium Concentration in Insulin-secreting Cells

Pteridines, 2006
We examined the role of endogenous tetrahydrobiopterin (BH4) on L-tyrosine-induced increase in cytosolic Ca: concentration ([Ca2+],) in the ß-cell line, HIT-T15.
Ishii Masakazu, Shimizu Shunichi, Watabe Tatsuya, Kiuchi Yuji   +3 more
doaj   +1 more source

Carbon Dots for Cancer Theranostics: Synthesis Strategies, Luminescence Properties, and Advances in Bioimaging‐Guided Diagnosis and Therapy

Chemistry – A European Journal, EarlyView.
Lighting up the path to precision oncology: This review comprehensively summarizes the rational design of carbon dots (CDs), elucidating how core size, surface chemistry, and heteroatom doping dictate their luminescence mechanisms. Special emphasis is placed on engineering NIR‐II emissive CDs for deep‐tissue imaging.
Zekun Yan, Yupeng Liu, Jinyun Tan, Songnan Qu   +3 more
wiley   +1 more source

Protective Effect of Tetrahydrobiopterin Against Reactive Oxygen Species- and Nitric Oxide-induced Vascular Endothelial Cell Injury

Pteridines, 2002
Vascular endothelial cells are one of the major biological targets of reactive oxygen species (ROS) in ischemiareperfusion, diabetes, hypercholesterolemia and inflammation.
Shimizu Shunichi
doaj   +1 more source