Results 121 to 130 of about 244,564 (198)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, Volume 20, Issue 10, Page 2533-2566, October 2026.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Targeting Integrins in Triple Negative Breast Cancer: Therapeutic Potential of Monoclonal Antibodies, PARP Inhibitors, Synthetic Peptides, and Aptamers

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Triple‐negative breast cancers (TNBCs) are associated with poor prognosis and chemoresistance. Recent reports indicate that extracellular matrix (ECM) molecules, such as integrins, could influence TNBC development. Integrins are adhesion macromolecules that modulate ECM characteristics such as stiffening of ECM and being associated with ...
Mobina Darabi, Zeynab Zahedi, Kosar Zolfaghari, Alireza Kordi, Kiarash Saleki, Niloufar Yazdanpanah, Nima Rezaei   +6 more
wiley   +1 more source

Ewing Sarcoma Family of Tumors

, 2010
The diagnosis and management of Ewing sarcoma is laborious and requires the correlation of multiple imaging modalities. This is an aggressive, malignant tumor of bone and soft tissue.
Amy Puchalski
core   +1 more source

CCNE1: A Cell Cycle Regulator That Influences Tumor Progression

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACTCyclin E1 (CCNE1), a pivotal member of the cyclin family, governs the G1/S phase transition of the cell cycle by binding to and activating cyclin‐dependent kinase 2 (CDK2), thereby initiating DNA replication and driving S‐phase entry. In a broad spectrum of human malignancies—including breast, ovarian, gastric, and non‐small cell lung cancers ...
Liang Yan, Siyi Liu, Yanling Li, Qian He, Chen Long, Ning Tang, Yanhong Zhou   +6 more
wiley   +1 more source

Actinomycin Analogs From Streptomyces polyantibioticus S4D258: Structural Elucidation and Antiproliferative Activity Against Triple‐Negative Breast Cancer

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Fifteen new actinomycin analogs, named actinomycins H1–H15, are identified from S. polyantibioticus S4D258. Actinomycins H7–H15 are truncated actinomycin analogs. Actinomycins H1–H6 and H9 exhibit significant antiproliferative activities against both MDA‐MB‐231 and 4T1 TNBC cells.
He Pang, Xiao‐Min Huang, Usama Ramadan Abdelmohsen, Li Shen, Jun Wu   +4 more
wiley   +1 more source

Prevalence and Risk Factors for Financial Toxicity Among Sarcoma Patients During and Following Treatment Across the Lifespan

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Financial toxicity (FT) describes the impact of cancer and treatment‐related financial burden. We evaluated the prevalence and risk factors for FT among sarcoma patients. Methods A sarcoma cohort was constructed to assess health outcomes.
Michael J. Robinson, Lili Sun, Tatsuki Koyama, Emma A. Schremp, Grace Aronoff, Tulio Guimaraes, Taylor A. Stokes, Elizabeth J. Davis, Vicki Keedy, Scott C. Borinstein, Herbert S. Schwartz, Jennifer L. Halpern, Joshua M. Lawrenz, Daniel Johnson, Timothy Su, Leo Luo, Travis Osterman, Tuya Pal, Ben H. Park, Xiao‐Ou Shu, Debra L. Friedman, Eric T. Shinohara   +21 more
wiley   +1 more source

Behavior Change Interventions to Promote Healthy Lifestyles Among Adolescent and Young Adult Childhood Cancer Survivors: A Scoping Review

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Adolescent and young adult childhood cancer survivors (AYA‐CCS) face elevated risks of chronic health conditions and premature mortality further exacerbated by poor lifestyle behaviors including physical inactivity, poor nutrition, and substance use.
C. Gélinas‐Gagné, K. Bilodeau, N. Guarascio, M. Caru, H. Coltin, D. Curnier, L. Desjardins, C. Laverdière, V. Marcil, R. Santiago, S. Vairy, S. Sultan   +11 more
wiley   +1 more source

Establishment of Salivary Gland Tumors Arising in Salivary Gland‐Specific EWSR1::ATF1 Transgenic Mice

Head &Neck, Volume 48, Issue 10, Page 2733-2744, October 2026.
ABSTRACT Background Salivary gland carcinomas are uncommon malignancies with various histological subtypes harboring fusion genes. The EWSR1::ATF1 fusion gene, resulting from a translocation between chromosomes 12 and 22, is frequently observed in hyalinizing clear cell carcinoma (HCCC). However, the role of this fusion gene in HCCC oncogenesis remains
Yuri Hirai, Yoshitaka Utsumi, Daisuke Sano, Tatsu Kuwahara, Yoshihiro Aizawa, Takashi Hatano, Hisashi Hasumi, Yutaro Soejima, Tatsukata Kawagoe, Ryosuke Jikuya, Nobuhisa Mizuki, Satoshi Fujii, Toshitaka Nagao, Nobuhiko Oridate   +13 more
wiley   +1 more source

Sinonasal Malignancies in Taiwan (2009–2019): Histologic Distribution, Overall Survival, and Temporal Trends in Hematological Versus Nonhematological Tumors

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 5, October 2026.
ABSTRACT Background Sinonasal malignancies are rare and histologically diverse, with limited population‐based data from Asia. This study investigated the histologic distribution, factors associated with overall survival (OS), and temporal survival patterns in Taiwan.
Chi‐Hsien Wu, Ching‐Heng Lin, Kai‐Li Liang   +2 more
wiley   +1 more source

Suicide gene therapy targeting ewing sarcoma via an ewing-specific GGAA promoter

Scientific Reports
We recently demonstrated that GGAA promoters (GGAAprom) can be used to drive the expression of therapeutic genes (i.e., Cas9) in vitro and in vivo in a highly specific way in Ewing sarcoma cells.
Saint T. Cervera, Selene Martínez, María Iranzo-Martínez, Raquel M. Melero-Fernández de Mera, Javier Alonso   +4 more
doaj   +1 more source