Results 111 to 120 of about 24,471 (221)

RNA helicase DDX3: a novel therapeutic target in Ewing sarcoma

, 2016
RNA helicase DDX3 has oncogenic activity in breast and lung cancers and is required for translation of complex mRNA transcripts, including those encoding key cell-cycle regulatory proteins.
DeVine, L R, Raman, V, Montgomery, E A, Loeb, D M, Kim, C, Wilky, B A, Kammers, K, McCarty, G, Cole, R N   +8 more
core   +1 more source

WT1 regulates angiogenesis in Ewing Sarcoma

, 2014
Angiogenesis is required for tumor growth. WT1, a protein that affects both mRNA transcription and splicing, has recently been shown to regulate expression of vascular endothelial growth factor (VEGF), one of the major mediators of angiogenesis.
Hans Hammers, Allen R. Chen, Montgomery, Elizabeth, Seth D. Goldstein, Katuri, Varalakshmi, Gerber, Stephanie, McCarty, Gregory, Loeb, David M., Xiaofei Qiu, Qiu, Xiaofei, Chen, Allen R., Varalakshimi Katuri, Elizabeth Montgomery, Hammers, Hans, Goldstein, Seth D., David M. Loeb, Stephanie Gerber, Gregory McCarty   +17 more
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Suicide gene therapy targeting ewing sarcoma via an ewing-specific GGAA promoter

Scientific Reports
We recently demonstrated that GGAA promoters (GGAAprom) can be used to drive the expression of therapeutic genes (i.e., Cas9) in vitro and in vivo in a highly specific way in Ewing sarcoma cells.
Saint T. Cervera, Selene Martínez, María Iranzo-Martínez, Raquel M. Melero-Fernández de Mera, Javier Alonso   +4 more
doaj   +1 more source

Advancing Preclinical Biology for Ewing Sarcoma: An International Effort. [PDF]

Ewing sarcoma is an aggressive bone and soft-tissue cancer affecting adolescents and young adults. In vitro and in vivo models of Ewing sarcoma have been instrumental in advancing our understanding of Ewing sarcoma biology and essential in evaluating ...
Feinberg, T.Y., Burchill, S.A., Nash, J.O., Roundhill, E.A., Grünewald, T.G.P., Ganapathi, S.S., Mora, J., Stewart, E.A., Amatruda, J.F., Kovar, H., Dela Cruz, F.S., Shlien, A., Grohar, P.J., Scotlandi, K., Soragni, A., Heske, C.M., Tomazou, E.M., Delattre, O., Pesic, D., Crompton, B.D., Lawlor, E.R., Ohm, J.E., Reed, D.R., Daley, J.D., Cohen-Gogo, S., Loeb, D.M., Surdez, D., Bailey, K.M., Alvarez-Perez, J.   +28 more
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Initial symptoms and clinical features in osteosarcoma and Ewing sarcoma

, 2000
BACKGROUND: The time between the initial symptoms of osteosarcoma and Ewing sarcoma and the correct diagnosis and treatment is long. Over the last two decades, the prognosis for patients with these diseases has dramatically improved due to a new ...
Widhe, T, Widhe, B,
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Nutlin-3a is a potential therapeutic for Ewing sarcoma

, 2011
Data source: Supplementary Figures, http://clincancerres.aacrjournals.org/content/17/3/494.figures-onlyPurpose: Although mutations in the TP53 gene occur in half of all cancers, approximately 90% of Ewing sarcomas retain a functional wild-type p53.
Al-ejeh, F., Evdokiou, Andreas, Callen, David F., Evdokiou, A., Zinonos, Irene, Callen, D., Al-Ejeh, Fares, Kumar, Raman, Paul Neilsen (9822326), Brown, Michael P., F Al-Ejeh (9884210), Irene Zinonos, R Kumar (6951491), Neilsen, P., DF Callen (9852704), KI Pishas (9883928), Fares Al-Ejeh, MP Brown (9884135), Kathleen I. Pishas, I Zinonos (9884243), A Evdokiou (9884138), Zinonos, I., Michael P. Brown, Pishas, K., Pishas, Kathleen I., Raman Kumar, Neilsen, Paul M., Kumar, R., Brown, M., David F. Callen, Paul M. Neilsen, Andreas Evdokiou   +31 more
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Abstract 1955: Targeting ribonucleotide reductase (RNR) in Ewing sarcoma

, 2017
Ewing sarcoma is a highly aggressive bone and soft tissue cancer that is caused by the EWS-FLI1 fusion protein. The EWS-FLI1 oncoprotein functions, in part, as an aberrant transcription factor and is required for tumor growth and survival.
Kelli Goss, Stacia Koppenhafer, David Gordon, Kathryn Harmoney   +3 more
core   +1 more source

Co-targeting JAK1/STAT6/GAS6/TAM signaling improves chemotherapy efficacy in Ewing sarcoma

Nature Communications
Ewing sarcoma is a pediatric bone and soft tissue tumor treated with chemotherapy, radiation, and surgery. Despite intensive multimodality therapy, ~50% patients eventually relapse and die of the disease due to chemoresistance.
Le Yu, Yu Deng, Xiaodong Wang, Charlene Santos, Ian J. Davis, H. Shelton Earp, Pengda Liu   +6 more
doaj   +1 more source

Ewing Sarcoma: An Eponym Window to History

, 2020
Ewing sarcoma was named after James R. Ewing, an eminent American pathologist at Cornell who described the first cases in 1921. Although he is best remembered for this singular achievement, Ewing's contributions to the study of cancer were far more ...
Timothy P Cripe
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Sarcoma de Ewing

, 2013
RESUMENFundamento: el sarcoma de Ewing es una neoplasia altamente maligna que afecta fundamentalmente a niños y adolescentes. Cerca del 95 % de estos sarcomas ocurren entre los 5-25 años, es frecuente en el sexo masculino y muy raro en la raza negra ...
Quintero Martínez, Osby, Hernández Cabezas, Ileydis, Mosquera Betancourt, Gretel, Hernández González, Erick Héctor   +3 more
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