Results 71 to 80 of about 208,351 (246)

Developing FGF2 Mutants with Selectively Reduced Heparan Sulfate Affinity to Explore Their Impact on FGFR1 Signaling

ChemBioChem, Accepted Article.
Fibroblast growth factor 2 (FGF2) regulates signal transduction by forming complexes with its receptors, FGF receptors (FGFRs), and heparan sulfate (HS), playing a crucial role in biological systems. Although HS has been suggested to modulate FGF/FGFR signaling as a co‐receptor, multiple hypotheses exist regarding how HS affects FGF/FGFR signaling, and
Yuga Okada, Akihiro Eguchi, Daisuke Kuroda, Kouhei Tsumoto, Ryosuke Ueki, Shinsuke Sando   +5 more
wiley   +1 more source

Pomalidomide for Symptomatic Kaposi's Sarcoma in People With and Without HIV Infection: A Phase I/II Study.

Journal of Clinical Oncology, 2016
Purpose Kaposi's sarcoma (KS) is a multicentric tumor caused by Kaposi's sarcoma-associated herpesvirus. Unmet needs include therapies that are oral, anthracycline sparing, and deliverable in resource-limited settings.
M. Polizzotto, T. Uldrick, K. Wyvill, K. Aleman, C. Peer, M. Bevans, I. Sereti, F. Maldarelli, D. Whitby, V. Marshall, P. Goncalves, V. Khetani, W. Figg, S. Steinberg, J. Zeldis, R. Yarchoan   +15 more
semanticscholar   +1 more source

Investigating the mechanisms of capsicum in age‐related hearing loss: Based on network pharmacology

Eye &ENT Research, EarlyView.
Abstract Background To explore the material basis and action mechanism of the chemical component gene of pepper on presbycusis, and to provide a reference for the traditional Chinese medicine treatment of age‐related hearing loss (ARHL). Methods The chemical composition and action targets of traditional Chinese medicine flavor of pepper were searched ...
Yan Wang, Xiaoyu Song, Fengxin Yang, Huhuifen He, Kun Zhao, Jingjing Qiu, Limei Cui, Qiang Zhang, Limei Liu, Yan Sun   +9 more
wiley   +1 more source

Local treatment with electrochemotherapy of superficial angiosarcomas: Efficacy and safety results from a multi-institutional retrospective study [PDF]

, 2016
Background: Angiosarcoma is an aggressive vascular neoplasm with a high propensity for local recurrence. Electrochemotherapy is an emerging skin-directed therapy, exerting prominent cytotoxic activity, and antivascular effects.
Bonadies, CARLO ALBERTO, Bucher, S, Cabula, C, Campana, Lg, Curatolo, Pietro, Grilz, G, Guida, M, Rossi, C. r., Rotunno, Roberta, Santoriello, Andrea, Solari, N, Strippoli, S, Valpione, S   +12 more
core   +1 more source

Aggressive conjunctival Kaposi sarcoma as the initial manifestation of acquired immunodeficiency syndrome

American Journal of Ophthalmology Case Reports, 2020
Purpose: To report a case of Kaposi sarcoma in a patient with previously undiagnosed Human Immunodeficiency Virus (HIV) infection. Observations: A 23-year-old male patient presented to the eye clinic with complaints of redness of his left eye for the ...
Christopher Donovan, Hershel Patel, Sirikishan Shetty, Lauren Bierman, Jay M. Lustbader, Aruoriwo M. Oboh-Weilke   +5 more
doaj  

Plaque‐Like Dermatofibroma: A Case Report and a Review of the Literature With a Focus on Dermoscopy

JEADV Clinical Practice, EarlyView.
ABSTRACT Plaque‐like dermatofibroma (PLDF) is a rare clinical variant of dermatofibroma (DF), characterised by flat, infiltrative lesions, often larger than 50 mm in diameter and located on the trunk or lower extremities. A 44‐year‐old male presented to our clinic with a 20 cm brownish plaque with peripheral satellite lesions on the right antecubital ...
Francesco Cavallo, Umberto Santaniello, Federica Santoro, Paolo Dapavo, Paolo Fava, Simone Ribero, Pietro Quaglino, Franco Picciotto   +7 more
wiley   +1 more source

Kaposi Sarcoma

Archives of Pathology & Laboratory Medicine, 2013
Kaposi sarcoma (KS) is a low-grade vascular tumor associated with Kaposi sarcoma herpesvirus/human herpesvirus 8 (KSHV/HHV8) infection. Kaposi sarcoma lesions predominantly present at mucocutaneous sites, but may involve all organs and anatomic locations. Recognized epidemiologic-clinical forms of KS include classic, African (endemic), AIDS-associated (
Oana, Radu, Liron, Pantanowitz
openaire   +2 more sources

Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor induced growth arrest and apoptosis through NF-κB activation [PDF]

, 2013
Kaposi's sarcoma-associated herpesvirus (KSHV) has been linked to the development of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease (MCD). We have characterized the role of KSHV-encoded viral FLICE inhibitory protein K13
Ahmad, B. Tolani, Ballon, Benhamou, Bower, Bren, C. Graham, Chang, Chaudhary, Chugh, Delmore, Dong, Du, Dupin, Dupin, Eeva, Eeva, Field, Gerondakis, Guasparri, H. Matta, H. Yi, Hassman, Herzog, Lee, Liu, Madureira, Matta, Matta, Matta, Matta, Mineva, Nador, Niiro, P. M. Chaudhary, Parravicini, Punj, Schauer, Soulier, Sun, Sun, Sun, Thome, Vrzalikova, Waterston, Wu, Wu, Wu, Y. Suo, Y. Yang, Yang, Yang, Young, Zhao   +53 more
core   +1 more source

SARCOMA DE KAPOSI ANAPLÁSICO MIMETIZANDO ANGIOSSARCOMA

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2014
Introdução: O angiossarcoma é o tumor vascular mais frequente no contexto de linfedema crónico, entidade conhecida como síndrome de Stewart-Treves. Contudo, é sabido que o sarcoma de Kaposi se acompanha frequentemente de linfedema (por vezes antecedendo ...
Vera Teixeira, José Carlos Cardoso, Miguel Pinto Gouveia, Angelina Mariano, Óscar Tellechea, Américo Figueiredo   +5 more
doaj   +1 more source

An Update on Kaposi’s Sarcoma: Epidemiology, Pathogenesis and Treatment

Dermatologic Therapy, 2016
Kaposi’s sarcoma is an angioproliferative neoplasm which has undergone considerable epidemiologic change since the original description by Moritz Kaposi in the late 1800s.
P. Curtiss, L. Strazzulla, A. Friedman-kien   +2 more
semanticscholar   +1 more source