Results 111 to 120 of about 698,336 (388)

Retrospective quality of life study in patients with retroperitoneal sarcoma in an Asian population

Health and Quality of Life Outcomes, 2020
Background Retroperitoneal sarcoma represents 15% of sarcomas. The mainstay of treatment is surgery where a majority of patients require multi-visceral resections that may significantly impact their quality of life (QOL) following surgery.
Hui Jun Lim, Chin-Ann Johnny Ong, Thakshayeni Skanthakumar, Lisa Yuen Hong Mak, Seettha Devi Wasudevan, Joey Wee-Shan Tan, Claramae Shulyn Chia, Grace Hwei Ching Tan, Melissa Ching Ching Teo   +8 more
doaj   +1 more source

Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group. [PDF]

, 2018
BackgroundNew prognostic markers are needed to identify patients with Ewing sarcoma (EWS) and osteosarcoma unlikely to benefit from standard therapy.
Barkauskas, Donald A, Clapp, Andrea, Crompton, Brian D, DuBois, Steven G, Gorlick, Richard, Ha, Gavin, Hall, David, Imamovic-Tuco, Alma, Janeway, Katherine A, Klega, Kelly, Krailo, Mark D, Leavey, Patrick J, Lessnick, Stephen L, London, Wendy B, Mascarenhas, Leo, Nag, Anwesha, Shulman, David S, Stegmaier, Kimberly, Thorner, Aaron R, Van Allen, Eliezer, Vo, Kieuhoa T   +20 more
core   +1 more source

Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro. [PDF]

, 2016
Synovial sarcoma is an aggressive soft tissue sarcoma genetically defined by the fusion oncogene SS18-SSX. It is hypothesized that either SS18-SSX disrupts SWI/SNF complex inhibition of the polycomb complex 2 (PRC2) methyltransferase Enhancer of Zeste ...
Choy, Edwin, Cote, Gregory M, Duan, Zhenfeng, Gao, Yan, Hornicek, Francis J, Mankin, Henry J, Shen, Jacson K   +6 more
core   +2 more sources

LOXHD1 and RHOB Expression by Monocytes Predicts Progressive Systemic Sclerosis associated Interstitial Lung Disease

Arthritis Care &Research, Accepted Article.
Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M Padilla, Robert Lafyatis, Kevin F Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J Kass   +13 more
wiley   +1 more source

Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations

Acta Neuropathologica, 2018
Patients with DICER1 predisposition syndrome have an increased risk to develop pleuropulmonary blastoma, cystic nephroma, embryonal rhabdomyosarcoma, and several other rare tumor entities.
C. Koelsche, M. Mynarek, D. Schrimpf, L. Bertero, J. Serrano, F. Sahm, D. Reuss, Yanghao Hou, D. Baumhoer, C. Vokuhl, U. Flucke, I. Petersen, W. Brück, S. Rutkowski, S. C. Zambrano, J. G. Garcia Leon, R. D. Diaz Coronado, M. Gessler, Ò. M. Tirado, J. Mora, J. Alonso, X. García del Muro, M. Esteller, D. Sturm, J. Ecker, T. Milde, S. Pfister, A. Korshunov, M. Snuderl, G. Mechtersheimer, U. Schüller, David T. W. Jones, A. von Deimling   +32 more
semanticscholar   +1 more source

Activation of NF‐κB Signaling by Optogenetic Clustering of IKKα and β

Advanced Biology, EarlyView.
This study presents an optogenetic approach for graded clustering of eGFP‐fused proteins using an eGFP‐specific nanobody and engineered Cryptochrome 2 variants. The method enables potent, reversible activation of NF‐κB signaling via endogenous pathways, as confirmed by RNA sequencing. This versatile system provides a spatially and temporally controlled
Alexandra Anna Maria Fischer, Markus Michael Kramer, Miguel Baños, Merlin Moritz Grimm, Manfred Fliegauf, Bodo Grimbacher, Gerald Radziwill, Sven Rahmann, Wilfried Weber   +8 more
wiley   +1 more source

Retrospective audit of 957 consecutive 18F-FDG PET–CT scans compared to CT and MRI in 493 patients with different histological subtypes of bone and soft tissue sarcoma

Clinical Sarcoma Research, 2018
BackgroundThe use of 18F-FDG PET–CT (PET–CT) is widespread in many cancer types compared to sarcoma. We report a large retrospective audit of PET–CT in bone and soft tissue sarcoma with varied grade in a single multi-disciplinary centre.
R. Macpherson, S. Pratap, H. Tyrrell, M. Khonsari, Shaun R Wilson, M. Gibbons, D. Whitwell, H. Giele, P. Critchley, Lucy Cogswell, S. Trent, N. Athanasou, K. Bradley, A. Hassan   +13 more
semanticscholar   +1 more source

An innovative staged prosthetic lengthening reconstruction strategy for osteosarcoma-related leg discrepancy

Scientific Reports
Correction of leg length discrepancy (LLD) in skeletally mature patients with osteosarcoma was rarely reported and quite challenging. This study aimed to propose a treatment strategy of staged lengthening and reconstruction with a standard static ...
Hairong Xu, Yuan Li, Feng Yu, Weifeng Liu, Lin Hao, Qing Zhang, Xiaohui Niu   +6 more
doaj   +1 more source

Multiple human herpesvirus-8 infection [PDF]

, 2003
In Malawian patients with Kaposi sarcoma (KS) and their relatives, we investigated nucleotide-sequence variation in human herpesvirus-8 (HHV-8) subgenomic DNA, amplified from oral and blood samples by use of polymerase chain reaction.
Beyari, MM, Cook, RD, Hodgson, TA, Kondowe, W, Molyneux, EM, Porter, SR, Scully, CM, Teo, CG   +7 more
core   +1 more source

Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications

Advanced Biology, EarlyView.
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran, Kieu Ngo, David Buob, Hanna Debiec, Pierre Ronco, Guillaume Perry   +5 more
wiley   +1 more source