Results 121 to 130 of about 738,044 (342)

PDL1 expression is a poor-prognosis factor in soft-tissue sarcomas

OncoImmunology, 2017
Soft-tissue sarcomas (STS) are a group of rare, heterogeneous, and aggressive tumors, with high metastatic risk and relatively few efficient systemic therapies.
François Bertucci, Pascal Finetti, Delphine Perrot, Agnès Leroux, Françoise Collin, Axel Le Cesne, Jean-Michel Coindre, Jean-Yves Blay, Daniel Birnbaum, Emilie Mamessier   +9 more
doaj   +1 more source

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source

Strengthening health data on a rare and heterogeneous disease: sarcoma incidence and histological subtypes in Germany

BMC Public Health, 2018
BackgroundThe population-based incidence of sarcoma and its histological subtypes in Germany is unknown. Up-to-date information on a disease with an incidence comparable to other cancer entities is of high public health relevance.
M. Ressing, E. Wardelmann, P. Hohenberger, J. Jakob, B. Kasper, K. Emrich, A. Eberle, M. Blettner, S. Zeissig   +8 more
semanticscholar   +1 more source

Endothelial Cells Angiogenesis in Sulfated Glycosaminoglycan (GAG) Hydrogels Enhanced by Bioactive Glass‐Released Ions

Advanced Functional Materials, EarlyView.
A mechanically tunable hydrogel composed of gelatin, chondroitin sulfate and laminin promotes angiogenesis in vitro without the supplement of growth factors. Endothelial cells morphogenesis was further enhanced by medium conditioned with bioactive glass 58S‐released ions (Ca and Si), thus offering a promising strategy to vascularize 3D tissue ...
Marco Piazzoni, Ilaria Borghi, Francesca Cadamuro, Sophia Dalfino, Riccardo Campanile, Sofia Nizzolo, Valeria Cassina, Francesca Tallia, Julian R. Jones, Francesco Mantegazza, Sabrina Bertini, Lorenzo Moroni, Francesco Nicotra, Laura Russo   +13 more
wiley   +1 more source

Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations

Acta Neuropathologica, 2018
Patients with DICER1 predisposition syndrome have an increased risk to develop pleuropulmonary blastoma, cystic nephroma, embryonal rhabdomyosarcoma, and several other rare tumor entities.
C. Koelsche, M. Mynarek, D. Schrimpf, L. Bertero, J. Serrano, F. Sahm, D. Reuss, Yanghao Hou, D. Baumhoer, Christian Vokuhl, U. Flucke, I. Petersen, W. Brück, S. Rutkowski, S. C. Zambrano, J. G. Garcia Leon, R. D. Diaz Coronado, M. Gessler, Ò. M. Tirado, J. Mora, J. Alonso, X. García del Muro, M. Esteller, D. Sturm, J. Ecker, T. Milde, S. Pfister, A. Korshunov, M. Snuderl, G. Mechtersheimer, U. Schüller, David T. W. Jones, A. von Deimling   +32 more
semanticscholar   +1 more source

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

Sternal Resection for Sarcoma, Recurrent Breast Cancer, and Radiation-Induced Necrosis [PDF]

, 2010
Linetta B. Koppert, Albertus N. van Geel, Titia E. Lans, Carmen van der Pol, Frits van Coevorden, Michel W.J.M. Wouters   +5 more
openalex   +1 more source

Retrospective audit of 957 consecutive 18F-FDG PET–CT scans compared to CT and MRI in 493 patients with different histological subtypes of bone and soft tissue sarcoma

Clinical Sarcoma Research, 2018
BackgroundThe use of 18F-FDG PET–CT (PET–CT) is widespread in many cancer types compared to sarcoma. We report a large retrospective audit of PET–CT in bone and soft tissue sarcoma with varied grade in a single multi-disciplinary centre.
R. Macpherson, S. Pratap, H. Tyrrell, M. Khonsari, Shaun R Wilson, M. Gibbons, D. Whitwell, H. Giele, P. Critchley, Lucy Cogswell, S. Trent, N. Athanasou, K. Bradley, A. Hassan   +13 more
semanticscholar   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Histiocytic Sarcoma in C57BL/6J Female Mice is Associated with Liver Hematopoiesis: Review of 41 Cases [PDF]

, 2003
Magali Lacroix‐Triki, Laetitia Lacoste-Collin, S. Jozan, Jean-Paul Charlet, C. Caratero, M. Courtade   +5 more
openalex   +1 more source