Results 101 to 110 of about 19,099 (312)
, 1986 Stretching a muscle results in a rapid addition of sarcomeres at the ends of the muscle fibers. The effect of a pattern of electrical stimulation resembling that of a slow motoneuron on the newly formed muscle tissue in a stretched, fast-contracting ...
Bicik, V. +3 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.We applied quantitative MRI of the lower limb and automated home‐cage phenotyping to a mouse model of calpainopathy to detect early disease changes. At 15 months, calpain 3‐deficient mice showed increased water T2 values correlating with immune cell infiltration in the soleus and gastrocnemius muscles, while assessment of motor activity revealed only ...
Nicolina Südkamp +12 more
wiley +1 more source
SMYD2 glutathionylation contributes to degradation of sarcomeric proteins
Nature Communications, 2018 Ischemic reperfusion or nutrient deprivation that produces reactive oxygen species can lead to a loss of muscle contractile function. Here the authors show that glutathionylation of the lysine methyltransferase SMYD2 contributes to degradation or ...
Dhanushka N. P. Munkanatta Godage +9 more
doaj +1 more source
Mechanics of Sarcomeres in Series and Instability - JURA Best Paper Award 2016-2017
, 2017 Sarcomeres are the smallest independent unit of force production in the muscle. Current theoretical models of sarcomere in series, i.e. a myofibril, predict instability on the descending limb region of the force-length relationship. However, experimental
Collette, Jared +2 more
core
The Anatomical Record, EarlyView.Abstract Muscle architecture is a major determinant of muscle performance and, in mammalian lineages, has been correlated with both feeding ecology and locomotor behaviors. Over the past decade, contrast‐enhanced micro‐CT (DiceCT) has emerged as an alternative to traditional dissection‐based measurement.
Aleksandra Ratkiewicz +5 more
wiley +1 more source
Nature Communications, 2018 Protein phosphatase 5 (PP5) is expressed in many cell types but its role in cardiomyocytes is unknown. Here the authors show that PP5 binds and dephosphorylates elastic titin in cardiac sarcomeres, and that PP5 is increased in heart failure, reducing ...
Judith Krysiak +10 more
doaj +1 more source
Biotechnology and Bioengineering, EarlyView.Human pluripotent stem cells were differentiated to cTnT+ cardiomyocytes and imaged throughout the process using phase contrast. We predicted differentiation efficiency (cTnT+ area) from phase contrast and compared model performance with a live‐cell cTnT‐GFP reporter.
Austin K. Feeney +6 more
wiley +1 more source
Cytoskeleton, EarlyView.ABSTRACT Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane‐fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin “strands” extend between separating chromosomes, connecting their ...
Demetra Economopoulos +5 more
wiley +1 more source
CONTRACTILE PROTEIN NUMBER IN ADJACENT SARCOMERES – IS THERE A DIFFERENCE?
, 2014 INTRODUCTION Variation in sarcomere length within an actively contracting skeletal muscle has often been observed yet remains unexplained. Sarcomeres within a myofibril are connected in series and thus they must each produce the same amount of force [1].
Antwi-Nsiah, Hilda +2 more
core
Acute loss of muscle attachment causes disorganisation and collapse of arrayed sarcomeres.
, 2012 Animals expressing a full length translational fusion of gfp to myo-3 (myosin heavy chain A) were age synchronised at L1 stage and grown to young adulthood at 16°C (t = 0 h).
Brandon D. Fields (188629) +6 more
core +1 more source