Results 81 to 90 of about 19,099 (312)

Synchronous behavior of spontaneous oscillations of sarcomeres in skeletal myofibrils under isotonic conditions

, 1996
An isotonic control system for studying dynamic properties of single myofibrils was developed to evaluate the change of sarcomere lengths in glycerinated skeletal myofibrils under conditions of spontaneous oscillatory contraction (SPOC) in the presence ...
Ishiwata, S., Shindo, Y., Yasuda, K.
core   +1 more source

Divergent Regulation of the Sarcomere and the Cytoskeleton [PDF]

Journal of Biological Chemistry, 2008
The existence of a feedback mechanism regulating the precise amounts of muscle structural proteins, such as actin and the actin-associated protein tropomyosin (Tm), in the sarcomeres of striated muscles is well established. However, the regulation of nonmuscle or cytoskeletal actin and Tms in nonmuscle cell structures has not been elucidated.
Galina, Schevzov, Thomas, Fath, Bernadette, Vrhovski, Nicole, Vlahovich, Sudarsan, Rajan, Jeff, Hook, Josephine E, Joya, Frances, Lemckert, Franz, Puttur, Jim J-C, Lin, Edna C, Hardeman, David F, Wieczorek, Geraldine M, O'Neill, Peter W, Gunning   +13 more
openaire   +2 more sources

Connexin 43‐Enriched Vesicles Improve Synchronization in hiPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Plasma membrane‐derived Connectosomes enriched in connexin‐43 are produced from donor hiPSCs and applied to hiPSC‐derived cardiomyocytes (hiPSC‐CMs). Connexin‐43 channels on Connectosomes remain functional, strengthening intercellular electrochemical coupling and increasing network synchronization over time.
Nima Momtahan, Anna K. McClain, Andrea Trementozzi, Sogu Sohn, Lingxia Qiao, Chi Zhao, Padmini Rangamani, Jeanne C. Stachowiak, Janet Zoldan   +8 more
wiley   +1 more source

Myomesin is organized into cardiac sarcomeres between 28 and 32hpf.

, 2019
At 28hpf, we could not detect any incorporated myomesin into the sarcomeres of wild-type embryo hearts (A-C). However at 32hpf, myomesin striations are easily visualized in the hearts of wild-type embryos (D-F; white arrowheads in F’).
Kendal Prill (3214215), Pamela J. Windsor Reid (7535051), David B. Pilgrim (7535054), Casey Carlisle (7535045), Megan Stannard (7535048)   +4 more
core   +1 more source

Developmentally Inspired Bioprinting of Nascent Multicellular Human Heart Tissue Through in Situ Differentiation and Morphogenesis of iPSCs

Advanced Science, EarlyView.
A developmentally inspired bioprinting approach enables the fabrication of pluripotent tissues that undergo shape‐morphing and in situ cardiac lineage specification. This method employs embedded bioprinting to deposit iPSCs within soft granular hydrogels to create pluripotent tissue constructs that undergo cell‐mediated shape morphogenesis.
Ankita Pramanick, Juhi Chakraborty, Orlaith Kennedy, Hey Wei Wong, Sogol Kianersi, Daniel Kelly, Vasileios Sergis, Abhay Pandit, Andrew C. Daly   +8 more
wiley   +1 more source

Sarcomere Dysfunction in Nemaline Myopathy

Journal of Neuromuscular Diseases, 2017
Nemaline myopathy (NM) is among the most common non-dystrophic congenital myopathies (incidence 1:50.000). Hallmark features of NM are skeletal muscle weakness and the presence of nemaline bodies in the muscle fiber. The clinical phenotype of NM patients is quite diverse, ranging from neonatal death to normal lifespan with almost normal motor function.
de Winter, Josine M, Ottenheijm, Coen A C   +1 more
openaire   +5 more sources

Sarcomeric dysfunction in heart failure [PDF]

Cardiovascular Research, 2007
Sarcomeric dysfunction plays a central role in reduced cardiac pump function in heart failure. This review focuses on the alterations in sarcomeric proteins in diseased myocardium that range from altered isoform expression to post-translational protein changes such as proteolysis and phosphorylation. Recent studies in animal models of heart failure and
Hamdani, N., Kooij, V., van Dijk, S.J., Merkus, D., Paulus, W.J., Remedios, C.D., Duncker, D.J., Stienen, G.J.M., van der Velden, J.   +8 more
openaire   +4 more sources

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source

NRAP reduction rescues sarcomere defects in nebulin-related nemaline myopathy [PDF]

, 2023
Jennifer G. Casey, Euri S Kim, Remi Joseph, Frank Li, Henk Granzier, Vandana Gupta   +5 more
openalex   +1 more source

Topology‐Enriched Toughness Enhancement in Quasi‐Periodic Metastructures Featuring Tailorable Strong‐Weak Network

Advanced Science, EarlyView.
A quasi‐periodic Dart‐Kite (QDK) metastructure with a golden‐ratio‐constrained strong–weak bond network simultaneously enhances strength, toughness, and damage tolerance. Its distributed topology enables predictable, tailorable crack paths for precise fracture control and stable mechanics, demonstrating a high‐performance, controllable architecture ...
Tianyu Gao, Genda Wang, Jiabao Bai, Kai Liu   +3 more
wiley   +1 more source