Results 71 to 80 of about 17,660 (277)

Molecular-scale visualization of sarcomere contraction within native cardiomyocytes

Nature Communications, 2021
Sarcomeres, the building blocks of striated muscles, comprise ordered actomyosin arrays involved in force production. Here, the authors visualize sarcomere organization in neonatal cardiomyocytes with in situ cryo-electron tomography, revealing a reduced
Laura Burbaum, Jonathan Schneider, Sarah Scholze, Ralph T. Böttcher, Wolfgang Baumeister, Petra Schwille, Jürgen M. Plitzko, Marion Jasnin   +7 more
doaj   +1 more source

Biceps femoris long head sarcomere and fascicle length adaptations after 3 weeks of eccentric exercise training

Journal of Sport and Health Science, 2022
Background: Eccentric exercise increases muscle fascicle lengths; however, the mechanisms behind this adaptation are still unknown. This study aimed to determine whether biceps femoris long head (BFlh) fascicle length increases in response to 3 weeks of ...
Patricio A. Pincheira, Melissa A. Boswell, Martino V. Franchi, Scott L. Delp, Glen A. Lichtwark   +4 more
doaj   +1 more source

On the mechanics of single sarcomeres.

Molecular & cellular biomechanics : MCB, 2010
This article has no abstract.
W. Herzog, V. Joumaa*, T.R. Leonard*   +2 more
openaire   +2 more sources

Sarcomeric TPM3α in developing chicken [PDF]

Cytoskeleton, 2017
AbstractCloning and sequencing of various tropomyosin isoforms expressed in chickens have been described since the early 1980s. However, to the best of our knowledge, this is the first report on the molecular characterization and the expression of the sarcomeric isoform of the TPM3 gene in cardiac and skeletal muscles from developing as well as adult ...
Syamalima, Dube, Lynn, Abbott, Samender, Randhawa, Yingli, Fan, Jushuo, Wang, Jean M, Sanger, Joseph W, Sanger, Bernard J, Poiesz, Dipak K, Dube   +8 more
openaire   +2 more sources

Cyclic Mechanical Loading of Cardiomyocytes via Pressure‐Driven Non‐Planar Membrane Deformation in a Bioreactor System

Advanced Science, EarlyView.
In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor, Gabrielle Juul, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Mark Bardin, Ryan Slusser, Abigail Glezer, Leda Klouda, Melikhan Tanyeri, Anita Saraf   +11 more
wiley   +1 more source

Celastrol‐Loaded Conductive Hydrogel Mitigates Myocardial Ischemia‐Reperfusion Injury and Restores Electrophysiological Function

Advanced Science, EarlyView.
Schematic illustration of the Pluronic F127 diacrylate/gelatin methacryloyl/poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)/celastrol hydrogel (FGPC) for localized myocardial ischemia–reperfusion injury treatment. FGPC combines sustained celastrol delivery with PEDOT:PSS‐mediated conductive support to attenuate acute oxidative/inflammatory ...
Shixin Wang, Shaojie Chen, Chengzong Li, Hongyi Cheng, Jincheng Jiao, Xiafeng Peng, Yike Zhang, Wei Sun, Feng Zhang, Chang Cui, Minglong Chen   +10 more
wiley   +1 more source

Titin-mediated thick filament activation stabilizes myofibrils on the descending limb of their force–length relationship

Journal of Sport and Health Science, 2018
Purpose: The aim of this study was to extend current half-sarcomere models by involving a recently found force-mediated activation of the thick filament and analyze the effect of this mechanosensing regulation on the length stability of half-sarcomeres ...
Gudrun Schappacher-Tilp
doaj   +1 more source

Mitochondrial network configuration influences sarcomere and myosin filament structure in striated muscles

Nature Communications, 2022
How different physical configurations between sarcomeres and mitochondria alter energetic support for contractile function of skeletal muscle is not clear.
Prasanna Katti, Alexander S. Hall, Hailey A. Parry, Peter T. Ajayi, Yuho Kim, T. Bradley Willingham, Christopher K. E. Bleck, Han Wen, Brian Glancy   +8 more
doaj   +1 more source

Breaking sarcomeres by in vitro exercise [PDF]

Scientific Reports, 2016
AbstractEccentric exercise leads to focal disruptions in the myofibrils, referred to as “lesions”. These structures are thought to contribute to the post-exercise muscle weakness and to represent areas of mechanical damage and/or remodelling. Lesions have been investigated in human biopsies and animal samples after exercise. However, this approach does
Zacharias Orfanos, Markus P. O. Gödderz, Ekaterina Soroka, Tobias Gödderz, Anastasia Rumyantseva, Peter F. M. van der Ven, Thomas J. Hawke, Dieter O. Fürst   +7 more
openaire   +2 more sources

Nanoscopic changes in the lattice structure of striated muscle sarcomeres involved in the mechanism of spontaneous oscillatory contraction (SPOC)

, 2020
Muscles perform a wide range of motile functions in animals. Among various types are skeletal and cardiac muscles, which exhibit a steady auto-oscillation of force and length when they are activated at an intermediate level of contraction.
Kono, Fumiaki, 1002437, Shin'ichi, Ishiwata, Fumiaki, Kono, 1002441, Shimamoto, Yuta, 1002440, Kawai, Seitaro, 1002439, 1002438   +9 more
core   +1 more source