Results 51 to 60 of about 17,660 (277)

Force-length relation of isometric sarcomeres in fixed-end tetani

, 1993
The higher force observed in fixed-end tetani relative to sarcomere-isometric tetani is commonly attributed to sarcomere length inhomogeneity; sarcomeres in the end regions of the fiber shorten extensively at the expense of the central sarcomeres.
A. Horowitz, G. H. Pollack
core   +1 more source

Polarization-resolved microscopy reveals a muscle myosin motor-independent mechanism of molecular actin ordering during sarcomere maturation.

PLoS Biology, 2018
Sarcomeres are stereotyped force-producing mini-machines of striated muscles. Each sarcomere contains a pseudocrystalline order of bipolar actin and myosin filaments, which are linked by titin filaments.
Olivier Loison, Manuela Weitkunat, Aynur Kaya-Çopur, Camila Nascimento Alves, Till Matzat, Maria L Spletter, Stefan Luschnig, Sophie Brasselet, Pierre-François Lenne, Frank Schnorrer   +9 more
doaj   +1 more source

Myocardial ultrastructure can augment genetic testing for sporadic dilated cardiomyopathy with initial heart failure

ESC Heart Failure, 2021
Aims The aim of the present study was to consider whether the ultrastructural features of cardiomyocytes in dilated cardiomyopathy can be used to guide genetic testing.
Tsunenori Saito, Naoko Saito Sato, Kosuke Mozawa, Akiko Adachi, Yoshihiro Sasaki, Kotoka Nakamura, Eiichiro Oka, Toshiaki Otsuka, Eitaro Kodani, Kuniya Asai, Kyoichi Mizuno, Wataru Shimizu, Roberta A. Gottlieb   +12 more
doaj   +1 more source

Optimal design of vertebrate and insect sarcomeres

, 1987
This paper offers a model for the normalized length‐tension relation of a muscle fiber based upon sarcomere design. Comparison with measurements published by Gordon et al.
Otten, E., E. Otten
core   +1 more source

The relative position of EDL muscle affects the length of sarcomeres within muscle fibers: experimental results and finite element modeling [PDF]

, 2003
Background: Effects of extramuscular connective tissues on muscle force (experimentally measured) and lengths of sarcomeres (modeled) were investigated in rat.
Koopmans, H.J.M.F, Grootenboer, H.J., Baan, Guus C., Koopman, Hubertus F.J.M.; id_orcid, Maas, H., Huijing, P.A.J.B.M., Yucesoy, C.A., Maas, H.; id_orcid, Maas, Huub   +8 more
core   +1 more source

KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination

eLife, 2017
Maintenance of muscle function requires assembly of contractile proteins into highly organized sarcomeres. Mutations in Kelch-like protein 41 (KLHL41) cause nemaline myopathy, a fatal muscle disorder associated with sarcomere disarray.
Andres Ramirez-Martinez, Bercin Kutluk Cenik, Svetlana Bezprozvannaya, Beibei Chen, Rhonda Bassel-Duby, Ning Liu, Eric N Olson   +6 more
doaj   +1 more source

Regulation of the evolutionarily conserved muscle myofibrillar matrix by cell type dependent and independent mechanisms

Nature Communications, 2022
Recent work has shown that mammalian muscle cells are comprised of multiple branching sarcomeres, though how this connectivity is regulated has remained unknown.
Peter T. Ajayi, Prasanna Katti, Yingfan Zhang, T. Bradley Willingham, Ye Sun, Christopher K. E. Bleck, Brian Glancy   +6 more
doaj   +1 more source

Combining Ultrafast Ultrasound and High-Density EMG to Assess Local Electromechanical Muscle Dynamics: A Feasibility Study

IEEE Access, 2021
Skeletal muscles generate force, enabling movement through a series of fast electro-mechanical activations coordinated by the central nervous system.
Rick Waasdorp, Winfred Mugge, Hendrik J. Vos, Jurriaan H. de Groot, Martin D. Verweij, Nico de Jong, Alfred C. Schouten, Verya Daeichin   +7 more
doaj   +1 more source

Molecular analysis of sarcomeric and non-sarcomeric genes in patients with hypertrophic cardiomyopathy [PDF]

Gene, 2016
Hypertrophic cardiomyopathy (HCM) is a common genetic heart disorder characterized by unexplained left ventricle hypertrophy associated with non-dilated ventricular chambers. Several genes encoding heart sarcomeric proteins have been associated to HCM, but a small proportion of HCM patients harbor alterations in other non-sarcomeric loci.
BOTTILLO, IRENE, D'ANGELANTONIO, DANIELA, CAPUTO, VIVIANA, PAIARDINI, ALESSANDRO, LIPARI, MARTINA, De Bernardo, C, Giannarelli, D, PIZZUTI, Antonio, Majore, S, Castori, M, Zachara, E, Re, F, GRAMMATICO, Paola   +12 more
openaire   +3 more sources

Synchronous behavior of spontaneous oscillations of sarcomeres in skeletal myofibrils under isotonic conditions [PDF]

, 1996
An isotonic control system for studying dynamic properties of single myofibrils was developed to evaluate the change of sarcomere lengths in glycerinated skeletal myofibrils under conditions of spontaneous oscillatory contraction (SPOC) in the presence ...
Ishiwata, S., Shindo, Y., Yasuda, K.
core   +1 more source