Results 31 to 40 of about 19,099 (312)

Distorting the sarcomere [PDF]

Journal of General Physiology, 2010
One of the goals of cardiovascular science is to create a mathematical model of the heart that can predict ventricular function in healthy and diseased states, and that can be used to help improve treatment options for patients with heart disease. To be clinically useful, the model will have to include structural information about the shapes of the ...
openaire   +2 more sources

Spontaneous sarcomere dynamics [PDF]

Chaos: An Interdisciplinary Journal of Nonlinear Science, 2010
Sarcomeres are the basic force generating units of striated muscles and consist of an interdigitating arrangement of actin and myosin filaments. While muscle contraction is usually triggered by neural signals, which eventually set myosin motors into motion, isolated sarcomeres can oscillate spontaneously between a contracted and a relaxed state.
Gunther, Stefan, Kruse, Karsten
openaire   +3 more sources

Ultrastructural Assessment and Proteomic Analysis in Myofibrillogenesis in the Heart Primordium After Heartbeat Initiation in Rats

Frontiers in Physiology, 2022
Myofibrillogenesis is an essential process for cardiogenesis and is closely related to excitation-contraction coupling and the maintenance of heartbeat.
Nobutoshi Ichise, Tatsuya Sato, Tatsuya Sato, Hiroyori Fusagawa, Hiroyori Fusagawa, Hiroya Yamazaki, Taiki Kudo, Izaya Ogon, Izaya Ogon, Noritsugu Tohse   +9 more
doaj   +1 more source

Rapid IFM Dissection for Visualizing Fluorescently Tagged Sarcomeric Proteins

Bio-Protocol, 2017
Sarcomeres, the smallest contractile unit of muscles, are arguably the most impressive actomyosin structure. Yet a complete understanding of sarcomere formation and maintenance is missing.
Yu Shu Xiao, Frieder Schöck, Nicanor González-Morales   +2 more
doaj   +1 more source

In vivo Sarcomere Lengths and Sarcomere Elongations Are Not Uniform across an Intact Muscle [PDF]

Frontiers in Physiology, 2016
Sarcomere lengths have been a crucial outcome measure for understanding and explaining basic muscle properties and muscle function. Sarcomere lengths for a given muscle are typically measured at a single spot, often in the mid-belly of the muscle, and at a given muscle length.
Herzog, Walter, Moo, Eng Kuan, Fortuna, Rafael, Sibole, Scott C., Abusara, Ziad   +4 more
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RHOT Proteins Link Mitochondrial Motility to Cardiomyocyte Sarcomere Maturation. [PDF]

Circ Res
Froese N, Shymotiuk I, Froese A, Polten F, Jablinski J, Scholz T, Korf-Klingebiel M, Werlein C, Galuppo P, Gigina A, Wihler K, Schneider J, Erschow S, Heimerl M, Szaroszyk M, Hegermann J, Wrede C, Schweitzer T, Pich A, Geffers R, Ricke-Hoch M, Kühnel MP, Jonigk DD, Wende AR, Abel ED, Nikolaev VO, Wollert KC, Bauersachs J, Riehle C.   +28 more
europepmc   +2 more sources

Muscle-specific stress fibers give rise to sarcomeres in cardiomyocytes

eLife, 2018
The sarcomere is the contractile unit within cardiomyocytes driving heart muscle contraction. We sought to test the mechanisms regulating actin and myosin filament assembly during sarcomere formation.
Aidan M Fenix, Abigail C Neininger, Nilay Taneja, Karren Hyde, Mike R Visetsouk, Ryan J Garde, Baohong Liu, Benjamin R Nixon, Annabelle E Manalo, Jason R Becker, Scott W Crawley, David M Bader, Matthew J Tyska, Qi Liu, Jennifer H Gutzman, Dylan T Burnette   +15 more
doaj   +1 more source

What Can We Learn from Single Sarcomere and Myofibril Preparations?

Frontiers in Physiology, 2022
Sarcomeres are the smallest functional contractile unit of muscle, and myofibrils are striated muscle organelles that are comprised of sarcomeres that are strictly aligned in series.
Walter Herzog
doaj   +1 more source

The force of the myosin motor sets cooperativity in thin filament activation of skeletal muscles

Communications Biology, 2022
Sarcomeres of Ca2 + -activated demembranated fibres of rabbit soleus muscles show that the stress exerted by each motor protein on the thin filament determines the cooperativity in thin filament activation. 
Marco Caremani, Matteo Marcello, Ilaria Morotti, Irene Pertici, Caterina Squarci, Massimo Reconditi, Pasquale Bianco, Gabriella Piazzesi, Vincenzo Lombardi, Marco Linari   +9 more
doaj   +1 more source

Force–length relation of skeletal muscles: from sarcomeres to myofibril [PDF]

, 2018
Sarcomeres are building blocks of skeletal muscles. Given force–length relations of sarcomeres serially connected in a myofibril, the myofibril force–length relation can be uniquely determined.
Hou, M.
core   +1 more source