Results 21 to 30 of about 17,660 (277)

Difference in Stretching of Sarcomeres between Medial Gastrocnemius and Tibialis Anterior by Tibial Lengthening: An Experiment in Rabbits

Journal of Orthopaedic Surgery, 2006
Purpose. To compare the degree of stretching of sarcomeres—in the medial gastrocnemius versus the tibialis anterior—acutely extended by tibial lengthening. Methods.
Kazuya Tamai, K Saotome
exaly   +2 more sources

Cell shape and maturation impacts α-actinin-2 tension in iPSC-derived cardiomyocytes [PDF]

APL Bioengineering
The contractile activity of cardiomyocytes (CMs) critical to heart function emerges from the collective shortening of sarcomeres. However, how these sarcomeric forces are transmitted within CMs during this process remains poorly understood.
Palash K. Dutta, Joshua M. Toth, Subramanian Sundaram, Xingyu Chen, Anant Chopra, Jourdan K. Ewoldt, Paige Cloonan, Xining Gao, Andrew S. LaCroix, Brenton D. Hoffman, Vivek B. Shenoy, Christine E. Seidman, Jonathan G. Seidman, Christopher S. Chen, Jeroen Eyckmans   +14 more
doaj   +2 more sources

Cell‐cycle regulation of sarcomere integrity—Role for Actn2 phosphorylation [PDF]

Physiological Reports
Sarcomeres are the fundamental contractile units of muscle. Despite their importance, sarcomere assembly remains poorly understood. We focused on Actn2, a protein which stabilizes the sarcomere by linking proteins to the Z‐disk.
S. S. Baksh, I. Anwar, X. Wang, R. E. Pratt, V. J. Dzau, C. P. Hodgkinson   +5 more
doaj   +2 more sources

Superresolution Microscopy of Drosophila Indirect Flight Muscle Sarcomeres

Bio-Protocol, 2020
Sarcomeres are extremely highly ordered macromolecular assemblies where proper structural organization is an absolute prerequisite to the functionality of these contractile units. Despite the wealth of information collected, the exact spatial arrangement
Szilard Szikora, Tibor Novák, Tamás Gajdos, Miklós Erdélyi, József Mihály   +4 more
doaj   +3 more sources

Sarcomere mechanics in striated muscles: from molecules to sarcomeres to cells [PDF]

American Journal of Physiology-Cell Physiology, 2017
Muscle contraction is commonly associated with the cross-bridge and sliding filament theories, which have received strong support from experiments conducted over the years in different laboratories. However, there are studies that cannot be readily explained by the theories, showing 1) a plateau of the force-length relation extended beyond optimal ...
Dilson E. Rassier
openaire   +3 more sources

Fluid flow in the sarcomere [PDF]

Archives of Biochemistry and Biophysics, 2021
A highly organized and densely packed lattice of molecular machinery within the sarcomeres of muscle cells powers contraction. Although many of the proteins that drive contraction have been studied extensively, the mechanical impact of fluid shearing within the lattice of molecular machinery has received minimal attention. It was recently proposed that
Sage A. Malingen, Kaitlyn Hood, Eric Lauga, Anette Hosoi, Thomas L. Daniel   +4 more
openaire   +4 more sources

Independent regulation of Z-lines and M-lines during sarcomere assembly in cardiac myocytes revealed by the automatic image analysis software sarcApp

eLife, 2023
Sarcomeres are the basic contractile units within cardiac myocytes, and the collective shortening of sarcomeres aligned along myofibrils generates the force driving the heartbeat.
Abigail C Neininger-Castro, James B Hayes, Zachary C Sanchez, Nilay Taneja, Aidan M Fenix, Satish Moparthi, Stéphane Vassilopoulos, Dylan Tyler Burnette   +7 more
doaj   +1 more source

Genotype-Phenotype Associations with Restrictive Cardiomyopathy Induced by Pathogenic Genetic Mutations

Reviews in Cardiovascular Medicine, 2022
Restrictive cardiomyopathy (RCM) is an uncommon cardiac muscle disease characterized by impaired ventricular filling and severe diastolic dysfunction with or without systolic dysfunction.
Zhe Yang, Jia Chen, Hong Li, Yubi Lin
doaj   +1 more source

Ion Channel Impairment and Myofilament Ca²⁺ Sensitization: Two Parallel Mechanisms Underlying Arrhythmogenesis in Hypertrophic Cardiomyopathy

Cells, 2021
Life-threatening ventricular arrhythmias are the main clinical burden in patients with hypertrophic cardiomyopathy (HCM), and frequently occur in young patients with mild structural disease.
Lorenzo Santini, Raffaele Coppini, Elisabetta Cerbai   +2 more
doaj   +1 more source

Sarcomere Length Nonuniformity and Force Regulation in Myofibrils and Sarcomeres [PDF]

Biophysical Journal, 2020
The smallest contractile unit in striated muscles is the sarcomere. Although some of the classic features of contraction assume a uniform behavior of sarcomeres within myofibrils, the occurrence of sarcomere length nonuniformities has been well recognized for years, but it is yet not well understood. In the past years, there has been a great advance in
Felipe de Souza Leite, Dilson E. Rassier
openaire   +2 more sources