Sarc-Graph: Automated segmentation, tracking, and analysis of sarcomeres in hiPSC-derived cardiomyocytes [PDF]
PLoS Computational Biology, 2021 A better fundamental understanding of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) has the potential to advance applications ranging from drug discovery to cardiac repair.
Emma Lejeune +2 more
exaly +3 more sources
Active Viscoelasticity of Sarcomeres [PDF]
Frontiers in Robotics and AI, 2018 The perturbation response of muscle is important for the versatile, stable and agile control capabilities of animals. Muscle resists being stretched by developing forces in the passive tissues and in the active crossbridges.
Khoi D. Nguyen +2 more
doaj +7 more sources
A Mathematical Model of Muscle Containing Heterogeneous Half-Sarcomeres Exhibits Residual Force Enhancement [PDF]
PLoS Computational Biology, 2011 A skeletal muscle fiber that is stimulated to contract and then stretched from L₁ to L₂ produces more force after the initial transient decays than if it is stimulated at L₂.
Campbell Ks, Sg Campbell
exaly +4 more sources
Computing Average Passive Forces in Sarcomeres in Length-Ramp Simulations [PDF]
PLoS Computational Biology, 2016 Passive forces in sarcomeres are mainly related to the giant protein titin. Titin's extensible region consists of spring-like elements acting in series.
Walter Herzog +2 more
exaly +3 more sources
Interactions between Connected Half-Sarcomeres Produce Emergent Mechanical Behavior in a Mathematical Model of Muscle [PDF]
PLoS Computational Biology, 2009 Most reductionist theories of muscle attribute a fiber's mechanical properties to the scaled behavior of a single half-sarcomere. Mathematical models of this type can explain many of the known mechanical properties of muscle but have to incorporate a ...
Campbell Ks
exaly +4 more sources
Peripheral thickening of the sarcomeres and pointed end elongation of the thin filaments are both promoted by SALS and its formin interaction partners [PDF]
PLoS GeneticsDuring striated muscle development the first periodically repeated units appear in the premyofibrils, consisting of immature sarcomeres that must undergo a substantial growth both in length and width, to reach their final size.
Miklós Erdelyi +2 more
exaly +4 more sources
Sarcomeric versus Non-Sarcomeric HCM
Cardiogenetics, 2023 Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiovascular disorder and is characterized by left ventricular hypertrophy (LVH), which is unexplained by abnormal loading conditions.
Felice Borrelli +8 more
doaj +3 more sources
Imaging of Zebrafish In Vivo with Second-Harmonic Generation Reveals Shortened Sarcomeres Associated with Myopathy Induced by Statin [PDF]
PLoS ONE, 2011 We employed second-harmonic generation (SHG) imaging and the zebrafish model to investigate the myopathy caused by statin in vivo with emphasis on the altered microstructures of the muscle sarcomere, the fundamental contractile element of muscles.
Shih-Hao Huang +2 more
exaly +3 more sources
Sarcomere dynamic instability and stochastic heterogeneity drive robust cardiomyocyte contraction [PDF]
eLifeCardiac contraction is driven by the collective action of cardiomyocytes (CMs) that contain parallel bundles of myofibrils consisting of linear chains of sarcomeres, the basic force-generating units.
Daniel Haertter +5 more
doaj +2 more sources
Signalling in sarcomeres in development and disease [PDF]
Netherlands Heart Journal, 2013 Sarcomeres are the smallest contractile units of heart and skeletal muscles and are essential for generation and propagation of mechanical force in these striated muscles. During the last decades it has become increasingly clear that components of sarcomeres also play a fundamental role in signal transduction in physiological and pathophysiological ...
Eldik, W. van, Passier, R.
openaire +5 more sources