Signalling in sarcomeres in development and disease [PDF]
Netherlands Heart Journal, 2013 Sarcomeres are the smallest contractile units of heart and skeletal muscles and are essential for generation and propagation of mechanical force in these striated mus-cles.
W. van Eldik +3 more
core +6 more sources
Force produced by isolated sarcomeres and half-sarcomeres after an imposed stretch
American Journal of Physiology - Cell Physiology, 2012 When a stretch is imposed to activated muscles, there is a residual force enhancement that persists after the stretch; the force is higher than that produced during an isometric contraction in the corresponding length.
Dilson E Rassier
exaly +4 more sources
Sarcomeric versus Non-Sarcomeric HCM
Cardiogenetics, 2023 Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiovascular disorder and is characterized by left ventricular hypertrophy (LVH), which is unexplained by abnormal loading conditions.
Felice Borrelli +8 more
doaj +3 more sources
Titin-dependent biomechanical feedback tailors sarcomeres to specialized muscle functions in insects. [PDF]
Sci AdvSarcomeres are the universal contractile units of muscles that enable animals to move. Insect muscles display a remarkable functional diversity: they operate at extremely different contraction frequencies (ranging from ~1 to 1000 hertz) and amplitudes ...
Loreau V +15 more
europepmc +3 more sources
Effects of strain on contractile force and number of sarcomeres in series of Xenopus laevis single muscle fibres during long-term culture [PDF]
Journal of Muscle Research and Cell Motility, 2004 The aim of the present study is to test whether mechanical strain uniquely regulates muscle fibre atrophy/hypertrophy and adaptation of the number of sarcomeres in series within mature muscle fibres in vitro.
Richard T Jaspers +2 more
exaly +2 more sources
Superresolution Microscopy of Drosophila Indirect Flight Muscle Sarcomeres
Bio-Protocol, 2020 Sarcomeres are extremely highly ordered macromolecular assemblies where proper structural organization is an absolute prerequisite to the functionality of these contractile units. Despite the wealth of information collected, the exact spatial arrangement
Szilard Szikora +4 more
doaj +3 more sources
Cofilin-2 Controls Actin Filament Length in Muscle Sarcomeres
Developmental Cell, 2014 International audienceADF/cofilins drive cytoskeletal dynamics by promoting the disassembly of "aged" ADP-actin filaments. Mammals express several ADF/cofilin isoforms, but their specific biochemical activities and cellular functions have not been ...
Elena Kremneva +2 more
exaly +2 more sources
Mathematical Modeling of the Dynamic Mechanical Behavior of Neighboring Sarcomeres in Actin Stress Fibers [PDF]
Cellular and Molecular Bioengineering, 2014 pre-printActin stress fibers (SFs) in live cells consist of series of dynamic individual sarcomeric units. Within a group of consecutive SF sarcomeres, individual sarcomeres can spontaneously shorten or lengthen without changing the overall length of ...
Mary C Beckerle
exaly +1 more source
Sarcomere mechanics in striated muscles: from molecules to sarcomeres to cells [PDF]
American Journal of Physiology-Cell Physiology, 2017 Muscle contraction is commonly associated with the cross-bridge and sliding filament theories, which have received strong support from experiments conducted over the years in different laboratories.
Dilson E. Rassier
core +3 more sources
Nature of motions between sarcomeres in asynchronously contracting cardiac muscle cells
, 1992 We observed the asynchronized motions that occur between the sarcomeres during spontaneous contractions to study the mechanical nature of the intact cardiac muscle cell (guinea pig, rat).
Siciliano, G., Krueger, J.W., Denton, A.
core +2 more sources