Results 11 to 20 of about 30,048 (267)

Sarcomeric versus Non-Sarcomeric HCM

Cardiogenetics, 2023
Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiovascular disorder and is characterized by left ventricular hypertrophy (LVH), which is unexplained by abnormal loading conditions.
Felice Borrelli, Maria Angela Losi, Grazia Canciello, Gaetano Todde, Errico Federico Perillo, Leopoldo Ordine, Giulia Frisso, Giovanni Esposito, Raffaella Lombardi   +8 more
doaj   +3 more sources

Sarcomere length non-uniformity and force regulation in myofibrils and sarcomeres. [PDF]

Biophysical Journal, 2020
The smallest contractile unit in striated muscles is the sarcomere. While some of the classic features of contraction assume a uniform behavior of sarcomeres within myofibrils, the occurrence of sarcomere length non-uniformities has been well-recognized ...
F. de Souza Leite, D. Rassier
semanticscholar   +3 more sources

Mathematical Modeling of the Dynamic Mechanical Behavior of Neighboring Sarcomeres in Actin Stress Fibers

Cellular and Molecular Bioengineering, 2014
Actin stress fibers (SFs) in live cells consist of series of dynamic individual sarcomeric units. Within a group of consecutive SF sarcomeres, individual sarcomeres can spontaneously shorten or lengthen without changing the overall length of this group ...
M C Beckerle
exaly   +2 more sources

Cell‐cycle regulation of sarcomere integrity—Role for Actn2 phosphorylation [PDF]

Physiological Reports
Sarcomeres are the fundamental contractile units of muscle. Despite their importance, sarcomere assembly remains poorly understood. We focused on Actn2, a protein which stabilizes the sarcomere by linking proteins to the Z‐disk.
S. S. Baksh, I. Anwar, X. Wang, R. E. Pratt, V. J. Dzau, C. P. Hodgkinson   +5 more
doaj   +2 more sources

Cofilin-2 Controls Actin Filament Length in Muscle Sarcomeres

Developmental Cell, 2014
SUMMARY ADF/cofilins drive cytoskeletal dynamics by promoting the disassembly of ‘aged’ ADP-actin filaments. Mammals express several ADF/cofilin isoforms, but their specific biochemical activities and cellular functions have not been studied in detail ...
Pekka Lappalainen, Alphee Michelot, Roberto Dominguez   +2 more
exaly   +2 more sources

Force produced after stretch in sarcomeres and half-sarcomeres isolated from skeletal muscles

Scientific Reports, 2013
The goal of this study was to evaluate if isolated sarcomeres and half-sarcomeres produce a long-lasting increase in force after a stretch is imposed during activation.
Marco Aurelio Vaz, Rassier D E, Fabio Carderelli Minozzo   +2 more
exaly   +2 more sources

Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres

Journal of Cell Biology, 2011
Contrary to prior models in which titin serves as a stable scaffold in sarcomeres, sarcomeric and soluble titin exchange dynamically in myofibers when calcium levels are low.
Michael Radke, Michael Gotthardt, Gotthardt Michael   +2 more
exaly   +2 more sources

Computing Average Passive Forces in Sarcomeres in Length-Ramp Simulations [PDF]

PLoS Computational Biology, 2016
Passive forces in sarcomeres are mainly related to the giant protein titin. Titin's extensible region consists of spring-like elements acting in series.
Gudrun Schappacher-Tilp, Timothy Leonard   +1 more
exaly   +2 more sources

Peripheral thickening of the sarcomeres and pointed end elongation of the thin filaments are both promoted by SALS and its formin interaction partners

PLoS Genetics
During striated muscle development the first periodically repeated units appear in the premyofibrils, consisting of immature sarcomeres that must undergo a substantial growth both in length and width, to reach their final size.
Miklós Erdelyi, Jijumon A S, Tamás Gajdoš   +2 more
exaly   +2 more sources

Signalling in sarcomeres in development and disease [PDF]

Netherlands Heart Journal, 2013
Sarcomeres are the smallest contractile units of heart and skeletal muscles and are essential for generation and propagation of mechanical force in these striated muscles.
W. V. van Eldik, R. Passier
semanticscholar   +4 more sources