Results 41 to 50 of about 19,099 (312)

Molecular analysis of sarcomeric and non-sarcomeric genes in patients with hypertrophic cardiomyopathy [PDF]

Gene, 2016
Hypertrophic cardiomyopathy (HCM) is a common genetic heart disorder characterized by unexplained left ventricle hypertrophy associated with non-dilated ventricular chambers. Several genes encoding heart sarcomeric proteins have been associated to HCM, but a small proportion of HCM patients harbor alterations in other non-sarcomeric loci.
BOTTILLO, IRENE, D'ANGELANTONIO, DANIELA, CAPUTO, VIVIANA, PAIARDINI, ALESSANDRO, LIPARI, MARTINA, De Bernardo, C, Giannarelli, D, PIZZUTI, Antonio, Majore, S, Castori, M, Zachara, E, Re, F, GRAMMATICO, Paola   +12 more
openaire   +3 more sources

Effects of physical training on sarcomere lengths and muscle-tendon interface of the cervical region in an experimental model of menopause

European Journal of Histochemistry, 2019
The aim of this study was to describe the structural and ultrastructural aspects of the myotendinous junction (MTJ) and the proximal and distal sarcomeres of the sternomastoid of aged Wistar rats subjected to an experimental model of menopause and ...
Carolina dos Santos Jacob, Lara Caetano Rocha, Jurandyr Pimentel Neto, Ii-sei Watanabe, Adriano Polican Ciena   +4 more
doaj   +1 more source

Induction of Proteasome Subunit Low Molecular Weight Protein (LMP)-2 Is Required to Induce Active Remodeling in Adult Rat Ventricular Cardiomyocytes

Medical Sciences, 2020
Isolated adult rat ventricular cardiomyocytes (ARVC) adapt to the two-dimensional surface of culture dishes once they are isolated from the three-dimensional heart tissue.
Antonia Petersen, Hanna Sarah Kutsche, Franziska Nippert, Rolf Schreckenberg, Rainer Schulz, Klaus-Dieter Schlüter   +5 more
doaj   +1 more source

Myofibril Changes in the Copepod Pseudodiaptomus marinus Exposed to Haline and Thermal Stresses. [PDF]

PLoS ONE, 2016
Copepods are small crustaceans capable to survive in various aquatic environments. Their responses to changes in different external factors such as salinity and temperature can be observed at different integration levels from copepod genes to copepod ...
Ali Ibrahim, Anissa Souissi, Aymeric Leray, Laurent Héliot, Bernard Vandenbunder, Sami Souissi   +5 more
doaj   +1 more source

Force-length relation of isometric sarcomeres in fixed-end tetani

, 1993
The higher force observed in fixed-end tetani relative to sarcomere-isometric tetani is commonly attributed to sarcomere length inhomogeneity; sarcomeres in the end regions of the fiber shorten extensively at the expense of the central sarcomeres.
A. Horowitz, G. H. Pollack
core   +1 more source

The relative position of EDL muscle affects the length of sarcomeres within muscle fibers: experimental results and finite element modeling [PDF]

, 2003
Background: Effects of extramuscular connective tissues on muscle force (experimentally measured) and lengths of sarcomeres (modeled) were investigated in rat.
Koopmans, H.J.M.F, Grootenboer, H.J., Baan, Guus C., Koopman, Hubertus F.J.M.; id_orcid, Maas, H., Huijing, P.A.J.B.M., Yucesoy, C.A., Maas, H.; id_orcid, Maas, Huub   +8 more
core   +1 more source

Polarization-resolved microscopy reveals a muscle myosin motor-independent mechanism of molecular actin ordering during sarcomere maturation.

PLoS Biology, 2018
Sarcomeres are stereotyped force-producing mini-machines of striated muscles. Each sarcomere contains a pseudocrystalline order of bipolar actin and myosin filaments, which are linked by titin filaments.
Olivier Loison, Manuela Weitkunat, Aynur Kaya-Çopur, Camila Nascimento Alves, Till Matzat, Maria L Spletter, Stefan Luschnig, Sophie Brasselet, Pierre-François Lenne, Frank Schnorrer   +9 more
doaj   +1 more source

Myocardial ultrastructure can augment genetic testing for sporadic dilated cardiomyopathy with initial heart failure

ESC Heart Failure, 2021
Aims The aim of the present study was to consider whether the ultrastructural features of cardiomyocytes in dilated cardiomyopathy can be used to guide genetic testing.
Tsunenori Saito, Naoko Saito Sato, Kosuke Mozawa, Akiko Adachi, Yoshihiro Sasaki, Kotoka Nakamura, Eiichiro Oka, Toshiaki Otsuka, Eitaro Kodani, Kuniya Asai, Kyoichi Mizuno, Wataru Shimizu, Roberta A. Gottlieb   +12 more
doaj   +1 more source

Optimal design of vertebrate and insect sarcomeres

, 1987
This paper offers a model for the normalized length‐tension relation of a muscle fiber based upon sarcomere design. Comparison with measurements published by Gordon et al.
Otten, E., E. Otten
core   +1 more source

Targets for therapy in sarcomeric cardiomyopathies [PDF]

Cardiovascular Research, 2015
To date, no compounds or interventions exist that treat or prevent sarcomeric cardiomyopathies. Established therapies currently improve the outcome, but novel therapies may be able to more fundamentally affect the disease process and course. Investigations of the pathomechanisms are generating molecular insights that can be useful for the design of ...
Tardiff JC, Carrier L, Bers DM, POGGESI, CORRADO, FERRANTINI, CECILIA, COPPINI, RAFFAELE, Maier LS, Ashrafian H, Huke S, van der Velden J.   +9 more
openaire   +6 more sources