Sarc-Graph: Automated segmentation, tracking, and analysis of sarcomeres in hiPSC-derived cardiomyocytes [PDF]
PLoS Computational Biology, 2021 A better fundamental understanding of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) has the potential to advance applications ranging from drug discovery to cardiac repair.
Bill Zhao +2 more
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A Mathematical Model of Muscle Containing Heterogeneous Half-Sarcomeres Exhibits Residual Force Enhancement [PDF]
PLoS Computational Biology, 2011 A skeletal muscle fiber that is stimulated to contract and then stretched from L₁ to L₂ produces more force after the initial transient decays than if it is stimulated at L₂.
Stuart G Campbell, Kenneth S Campbell
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Active Viscoelasticity of Sarcomeres [PDF]
Frontiers in Robotics and AI, 2018 The perturbation response of muscle is important for the versatile, stable and agile control capabilities of animals. Muscle resists being stretched by developing forces in the passive tissues and in the active crossbridges.
Khoi D. Nguyen +2 more
doaj +4 more sources
Peripheral thickening of the sarcomeres and pointed end elongation of the thin filaments are both promoted by SALS and its formin interaction partners [PDF]
PLoS GeneticsDuring striated muscle development the first periodically repeated units appear in the premyofibrils, consisting of immature sarcomeres that must undergo a substantial growth both in length and width, to reach their final size.
David Farkaš +2 more
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Computing Average Passive Forces in Sarcomeres in Length-Ramp Simulations [PDF]
PLoS Computational Biology, 2016 Passive forces in sarcomeres are mainly related to the giant protein titin. Titin's extensible region consists of spring-like elements acting in series.
Gudrun Schappacher-Tilp +2 more
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Interactions between Connected Half-Sarcomeres Produce Emergent Mechanical Behavior in a Mathematical Model of Muscle [PDF]
PLoS Computational Biology, 2009 Most reductionist theories of muscle attribute a fiber's mechanical properties to the scaled behavior of a single half-sarcomere. Mathematical models of this type can explain many of the known mechanical properties of muscle but have to incorporate a ...
Kenneth S Campbell
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Imaging of Zebrafish In Vivo with Second-Harmonic Generation Reveals Shortened Sarcomeres Associated with Myopathy Induced by Statin [PDF]
PLoS ONE, 2011 We employed second-harmonic generation (SHG) imaging and the zebrafish model to investigate the myopathy caused by statin in vivo with emphasis on the altered microstructures of the muscle sarcomere, the fundamental contractile element of muscles.
Shih-Hao Huang +2 more
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Cell shape and maturation impacts α-actinin-2 tension in iPSC-derived cardiomyocytes [PDF]
APL BioengineeringThe contractile activity of cardiomyocytes (CMs) critical to heart function emerges from the collective shortening of sarcomeres. However, how these sarcomeric forces are transmitted within CMs during this process remains poorly understood.
Palash K. Dutta +14 more
doaj +2 more sources
Journal of Orthopaedic Surgery, 2006 Purpose. To compare the degree of stretching of sarcomeres—in the medial gastrocnemius versus the tibialis anterior—acutely extended by tibial lengthening. Methods.
Kazuya Tamai +2 more
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Cell‐cycle regulation of sarcomere integrity—Role for Actn2 phosphorylation [PDF]
Physiological ReportsSarcomeres are the fundamental contractile units of muscle. Despite their importance, sarcomere assembly remains poorly understood. We focused on Actn2, a protein which stabilizes the sarcomere by linking proteins to the Z‐disk.
S. S. Baksh +5 more
doaj +2 more sources