Sarc-Graph: Automated segmentation, tracking, and analysis of sarcomeres in hiPSC-derived cardiomyocytes [PDF]
PLoS Computational Biology, 2021 A better fundamental understanding of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) has the potential to advance applications ranging from drug discovery to cardiac repair.
Emma Lejeune +2 more
exaly +3 more sources
A Mathematical Model of Muscle Containing Heterogeneous Half-Sarcomeres Exhibits Residual Force Enhancement [PDF]
PLoS Computational Biology, 2011 A skeletal muscle fiber that is stimulated to contract and then stretched from L₁ to L₂ produces more force after the initial transient decays than if it is stimulated at L₂.
Campbell Ks, Sg Campbell
exaly +3 more sources
Interactions between Connected Half-Sarcomeres Produce Emergent Mechanical Behavior in a Mathematical Model of Muscle [PDF]
PLoS Computational Biology, 2009 Most reductionist theories of muscle attribute a fiber's mechanical properties to the scaled behavior of a single half-sarcomere. Mathematical models of this type can explain many of the known mechanical properties of muscle but have to incorporate a ...
Campbell Ks
exaly +3 more sources
Imaging of Zebrafish In Vivo with Second-Harmonic Generation Reveals Shortened Sarcomeres Associated with Myopathy Induced by Statin [PDF]
PLoS ONE, 2011 We employed second-harmonic generation (SHG) imaging and the zebrafish model to investigate the myopathy caused by statin in vivo with emphasis on the altered microstructures of the muscle sarcomere, the fundamental contractile element of muscles.
Shih-Hao Huang +2 more
exaly +3 more sources
Active Viscoelasticity of Sarcomeres
Frontiers in Robotics and AI, 2018 The perturbation response of muscle is important for the versatile, stable and agile control capabilities of animals. Muscle resists being stretched by developing forces in the passive tissues and in the active crossbridges.
Khoi D. Nguyen +2 more
doaj +2 more sources
Muscle-specific stress fibers give rise to sarcomeres in cardiomyocytes
eLife, 2018 The sarcomere is the contractile unit within cardiomyocytes driving heart muscle contraction. We sought to test the mechanisms regulating actin and myosin filament assembly during sarcomere formation.
Aidan M Fenix +15 more
doaj +2 more sources
KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination
eLife, 2017 Maintenance of muscle function requires assembly of contractile proteins into highly organized sarcomeres. Mutations in Kelch-like protein 41 (KLHL41) cause nemaline myopathy, a fatal muscle disorder associated with sarcomere disarray.
Andres Ramirez-Martinez +6 more
doaj +2 more sources
Journal of Orthopaedic Surgery, 2006 Purpose. To compare the degree of stretching of sarcomeres—in the medial gastrocnemius versus the tibialis anterior—acutely extended by tibial lengthening. Methods.
Kazuya Tamai, K Saotome
exaly +2 more sources
Cell shape and maturation impacts α-actinin-2 tension in iPSC-derived cardiomyocytes [PDF]
APL BioengineeringThe contractile activity of cardiomyocytes (CMs) critical to heart function emerges from the collective shortening of sarcomeres. However, how these sarcomeric forces are transmitted within CMs during this process remains poorly understood.
Palash K. Dutta +14 more
doaj +2 more sources
Superresolution Microscopy of Drosophila Indirect Flight Muscle Sarcomeres
Bio-Protocol, 2020 Sarcomeres are extremely highly ordered macromolecular assemblies where proper structural organization is an absolute prerequisite to the functionality of these contractile units. Despite the wealth of information collected, the exact spatial arrangement
Szilard Szikora +4 more
doaj +2 more sources