Results 171 to 180 of about 19,099 (312)
Examination of FGFRL1 as a candidate gene for diaphragmatic defects at chromosome 4p16.3 shows that Fgfrl1 null mice have reduced expression of Tpm3, sarcomere genes and Lrtm1 in the diaphragm [PDF]
, 2009 Nelson D. LopezJimenez +8 more
openalex +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu +7 more
wiley +1 more source
Stepwise Dynamics of Connecting Filaments Measured in Single Myofibrillar Sarcomeres [PDF]
, 1998 Paul Yang +2 more
openalex +1 more source
Insights from electromechanical simulations to assess omecamtiv mecarbil efficacy in heart failure
The Journal of Physiology, EarlyView.Abstract figure legend Impact of Omecamtiv Mecarbil (OM) on in‐silico models of heart failure. A mathematical electromechanical model of human ventricular tissue is used to simulate the effects of OM in heart failure with reduced ejection fraction (HFrEF).
Maria Teresa Mora +8 more
wiley +1 more source
Residual force depression in single sarcomeres is abolished by MgADP-induced activation
, 2015 The mechanisms of force depression commonly observed during active shortening in skeletal muscles remain elusive. One major limitation to force depression research has been the inability of experimental preparations to directly isolate the two most ...
Trecarten, Neal
core
Asynchronous movement of sarcomeres in myocardium under living conditions: role of titin
In summary, recent nano-imaging studies have revealed that the length of each sarcomere does not change in a synchronous fashion throughout excitation-contraction coupling in myocytes in the beating heart in vivo (Kobirumaki-Shimozawa et al., 2016 ...
Tomohiro Nakanishi +4 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend In this study, we used mathematical modelling to explore the effect of diabetes on muscle mechanoenergetics. Our parameterisation of cross‐bridge models using data from non‐diabetic and diabetic human atrial tissues revealed lower values for cross‐bridge stiffness, detachment rates, attachment rates and lower ATP sensitivity in ...
Julia H. Musgrave +4 more
wiley +1 more source
A deep learning‐enabled toolkit for the 3D segmentation of ventricular cardiomyocytes
The Journal of Physiology, EarlyView.Abstract figure legend 3D cardiomyocyte segmentation enables comprehensive analyses of myocardial microstructure in health and disease; however, it is technically demanding. We present an open‐source toolkit for this task, which reduces challenges associated with sample preparation, image restoration, segmentation and proofreading.
Joachim Greiner +6 more
wiley +1 more source