Results 181 to 190 of about 30,048 (267)

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no definitive cure is currently available. As a consequence, therapeutic efforts
Raffaele Epis, Gabriele Rovetta, Giulia Ferrari, Chiara Bonfanti, Giorgia Careccia, Graziella Messina   +5 more
wiley   +1 more source

Reduced Expression of MTSS1 Increases Sarcomere Number and Improves Contractility in Select Forms of Monogenic DCM. [PDF]

JACC Basic Transl Sci
Kleppe H, Budan A, Zhang L, Majetic M, Shenwai R, Levinson AR, Cisne-Thompson O, Zepeda B, MacKay CE, Farshidfar F, Tsui JH, Figarska SM, Hoey T, Priest JR, Slater RE.   +14 more
europepmc   +1 more source

Coronary Microvascular Dysfunction: Epidemiology, Pathophysiology, Diagnosis, and Treatment

MedComm, Volume 7, Issue 8, August 2026.
This visual summary illustrates the key aspects of coronary microvascular dysfunction (CMD) in angina with nonobstructive coronary artery disease (NOCAD), including epidemiology, pathophysiology (microvascular remodeling and endothelial dysfunction), the protective NRG‐1/ErbB signaling pathway, diagnostic methods, and both Western and traditional ...
Zhao Ge, MaoZe Zhang, Xujin Ning, Yijia Du, Lishuo Su, Xudong Wu, Jingyi Zhang, Tongzuo Liu, Xianliang Wang   +8 more
wiley   +1 more source

Titin's P-zone domains A164-167 are essential for thick filament structural arrangement. [PDF]

J Gen Physiol
Hoover Browne C, Han SW, Farman GP, Smith JE, Kolb J, Gohlke J, Langlais PR, Tonino P, Methawasin M, van der Pijl R, Granzier H.   +10 more
europepmc   +1 more source

Cardiovascular Diseases and Cancer: Convergent Proteostasis Networks at the Crossroads of Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 8, August 2026.
The disruption of proteostasis, encompassing the ubiquitin–proteasome system, autophagy, UPR/ER stress, and chaperone function, represents a fundamental mechanism shared by both cancer and cardiovascular diseases. While these pathways frequently facilitate tumor progression, they are crucial for maintaining proteostasis in cardiac tissue. Consequently,
Jacob Eli García Torres, Norbert Frey, Ashraf Yusuf Rangrez   +2 more
wiley   +1 more source

Muscle growth by sarcomere divisions. [PDF]

Sci Adv
Rodier C, Estabrook ID, Chan EH, Rice G, Loreau V, Raunser S, Görlich D, Friedrich BM, Schnorrer F.   +8 more
europepmc   +1 more source

Transcriptomic comparative study between canalicular adenoma and HMGA2::WIF1 canalicular‐like pleomorphic adenoma

The Journal of Pathology, Volume 269, Issue 4-5, Page 423-432, August 2026.
Abstract Canalicular adenoma (CA) is a benign salivary gland tumor predominantly affecting the upper lip and is characterized by monomorphic epithelial cells arranged in branching cords within a loose and vascularized stroma. Unlike pleomorphic adenoma (PA), CA lacks a chondroid matrix and exhibits specific histological features, such as high cuboidal ...
Ziyad Alsugair, Anne Champagnac, Maxime Fieux, Pierre Philouze, Philippe Ceruse, Brice Thamphya, Daniel Pissaloux, Franck Tirode, Nazim Benzerdjeb   +8 more
wiley   +1 more source

Oligomer-dependent and oligomer-independent pathogenesis of muscular dystrophy-associated mutations within the penta-EF-hand domain of calpain-3. [PDF]

J Biol Chem
Hisatsune C, Shinkai-Ouchi F, Hata S, Ono Y.   +3 more
europepmc   +1 more source

Residual force enhancement in myofibrils and sarcomeres

Proceedings of the Royal Society of London. Biological Sciences, 2008
V. Joumaa, T. Leonard, Walter Herzog
semanticscholar   +1 more source

Construction and Validation of Plasma Protein‐Based Musculoskeletal Biological Age and Genetic and Environmental Risk Profiles

Aging Cell, Volume 25, Issue 8, August 2026.
We developed plasma protein‐based musculoskeletal aging clocks, MSKAge and MSKAgeMort, using UK Biobank proteomic data, and showed that MSKAgeAccel and MSKAgeMortAccel (in particular) predicted mortality, musculoskeletal disorders, and age‐related diseases effectively.
Yangdan Zhong, Maoyao Xia, Xunying Zhao, Yang Qu, Bowen Lei, Sirui Zhen, Tao Han, Rong Xiang, Jinyu Xiao, Xin Song, Xiaofeng Ma, Bin Yang, Di Zhang, Jinyu Zhou, Zilan Chen, Yuqi Pang, Ye Ju, Ting Liu, Zihao Li, Lu Long, Tao Zhang, Jiayuan Li, Mengyu Fan, Zuyun Liu, Xia Jiang   +24 more
wiley   +1 more source