Results 281 to 290 of about 19,099 (312)
Some of the next articles are maybe not open access.
The Cardiac Sarcomere and Cell Cycle
Current Cardiology Reports, 2022The lack of adult human cardiomyocyte proliferative capacity impairs cardiac regeneration such as after myocardial injury. The sarcomere, a specialized actin cytoskeletal structure that is essential for twitch contraction in cardiomyocytes, has been considered a critical factor limiting adult human cardiomyocyte proliferation through incompletely ...
Anthony M. Pettinato +2 more
openaire +2 more sources
Dysfunctional sarcomeric relaxation in the heart
Current Opinion in Physiology, 2022Since cardiac relaxation is commonly impaired in heart failure caused by many different etiologies, identifying druggable targets is a common goal. While many factors contribute to cardiac relaxation, this review focuses on sarcomeric relaxation and dysfunction.
Walter E, Knight, Kathleen C, Woulfe
openaire +2 more sources
Targeting the sarcomere in inherited cardiomyopathies
Nature Reviews Cardiology, 2022Variants in >12 genes encoding sarcomeric proteins can cause various cardiomyopathies. The two most common are hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Current therapeutics do not target the root causes of these diseases, but attempt to prevent disease progression and/or to manage symptoms.
Sarah J. Lehman +2 more
openaire +2 more sources
Atomistic Simulations of Sarcomere Proteins
2023Concerted atomic motions are requisite for sarcomere protein function and may become disrupted in HCM pathologies. Computational approaches such as molecular dynamics simulation can resolve such dynamics with unrivalled spatial and temporal resolution.
Matthew Carter, Childers +1 more
openaire +2 more sources
Sarcomeric Genotyping in Hypertrophic Cardiomyopathy
Mayo Clinic Proceedings, 2005To pool results from studies of patients with hypertrophic cardiomyopathy (HCM) to elucidate important phenotypic differences among genotypes.Data published from November 1998 through November 2004 were gathered and compared from unrelated study population genotyping studies from the Mayo Clinic (Rochester, Minn), Harvard Medical School (Boston, Mass),
Sara L, Van Driest +4 more
openaire +2 more sources
Myofilaments: Movers and Rulers of the Sarcomere
Comprehensive Physiology, 2017ABSTRACT Striated cardiac and skeletal muscles play very different roles in the body, but they are similar at the molecular level. In particular, contraction, regardless of the type of muscle, is a precise and complex process involving the integral protein myofilaments and their associated regulatory components ...
Brian Leei, Lin +2 more
openaire +2 more sources
2010
Skeletal muscle cells, more commonly called muscle fibres, are multinucleated syncytia formed during development by fusion of mononucleated precursor cells, the myoblasts. They measure 10–100 μm in diameter and can have lengths from a few millimeters up to almost a meter.
Margit Pavelka, Jürgen Roth
openaire +1 more source
Skeletal muscle cells, more commonly called muscle fibres, are multinucleated syncytia formed during development by fusion of mononucleated precursor cells, the myoblasts. They measure 10–100 μm in diameter and can have lengths from a few millimeters up to almost a meter.
Margit Pavelka, Jürgen Roth
openaire +1 more source
1989
Studies on the mechanics of sarcomeres at the level of single myofibrils or single myocytes revealed properties not predicted by the cross-bridge theory of muscle contraction. This paper summarizes four major aspects: 1. Passive compression of the sarcomere showed two inflections in the force length curve; one was at the length where opposing ...
openaire +1 more source
Studies on the mechanics of sarcomeres at the level of single myofibrils or single myocytes revealed properties not predicted by the cross-bridge theory of muscle contraction. This paper summarizes four major aspects: 1. Passive compression of the sarcomere showed two inflections in the force length curve; one was at the length where opposing ...
openaire +1 more source
Architecture and function in the muscle sarcomere
Current Opinion in Structural Biology, 1997Striated muscle sarcomeres in vertebrates comprise ordered arrays of actin and myosin filaments, organized by an elaborate protein scaffold. Recent innovative work in a number of laboratories has greatly improved our knowledge of these structures, their organization and their interactions.
openaire +2 more sources
Inherited disorders of sarcomeric proteins
Current Opinion in Neurology, 1999The most important advances in sarcomeric protein diseases continue to be the identification of mutated genes responsible for human diseases. These have recently included those that encode skeletal muscle alpha-actin in autosomal dominant and autosomal recessive nemaline myopathy, nebulin and slow alpha-tropomyosin in autosomal recessive nemaline ...
openaire +2 more sources