Results 241 to 250 of about 169,719 (379)

Muscle Cathepsin B Treatment Improves Behavioral and Neurogenic Deficits in a Mouse Model of Alzheimer's Disease

open access: yesAging Cell, EarlyView.
Targeting muscle with Cathepsin B (Ctsb) to treat the AD mouse brain. In this study, an AAV‐vector‐mediated approach, utilized to express Ctsb in muscle, prevented mnemonic and neurogenic deficits and normalized hippocampal, muscle, and plasma proteomic profiles.
Alejandro Pinto   +16 more
wiley   +1 more source

Identification of biomarkers associated with glycolysis and lactation in sarcopenia. [PDF]

open access: yesSci Rep
Luo X   +11 more
europepmc   +1 more source

PVSS5. Frailty, Sarcopenia, and Mortality in Aortic Surgery Patients [PDF]

open access: bronze, 2010
Shaun P. Patel   +8 more
openalex   +1 more source

Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Cognitive Decline by Restoring Senescent Microglial Function via NF‐κB‐SREBP1 Pathway Inhibition

open access: yesAging Cell, EarlyView.
Human umbilical cord‐derived mesenchymal stem cells (hUC‐MSCs) ameliorate age‐related cognitive decline by targeting senescent microglia. They attenuate microglial senescence, reduce LD accumulation, and inhibit the NF‐κB‐SREBP1 signaling pathway, ultimately mitigating neuroinflammation and neuronal damage.
Aihong Liang   +13 more
wiley   +1 more source

Development of a Novel Frailty Trigger for Use at Triage in the Emergency Department

open access: yesAcademic Emergency Medicine, EarlyView.
ABSTRACT Background Emergency Department (ED) Triage identifies patients with urgent needs. Frailty is not routinely identified and older patients presenting atypically may be inappropriately triaged as low priority. The introduction of a frailty modifier at triage is recommended in international guidelines, but is not yet widely‐adopted.
Elizabeth Moloney   +6 more
wiley   +1 more source

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