Results 71 to 80 of about 6,398 (198)

SARM constructs and their nuclear transport and localization patterns.

, 2013
A. Design of SARM constructs used in this study. SARM's modular structure is comprised of ARM repeats (blue), a SAM domain (pink) and a TIR domain (orange).
Jacek Hawiger (334056), Chad R. Sethman (438889)   +1 more
core   +1 more source

Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans

Cell Reports, 2023
Summary: Wallerian axonal degeneration (WD) does not occur in the nematode C. elegans, in contrast to other model animals. However, WD depends on the NADase activity of SARM1, a protein that is also expressed in C. elegans (ceSARM/ceTIR-1).
Tami Khazma, Atira Grossman, Julia Guez-Haddad, Chengye Feng, Hadas Dabas, Radhika Sain, Michal Weitman, Ran Zalk, Michail N. Isupov, Marc Hammarlund, Michael Hons, Yarden Opatowsky   +11 more
doaj   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

Actividad in vitro del tedizolid y de antibióticos de comparación en aislamientos de Staphylococcus aureus resistentes a meticilina en infecciones de piel y tejidos blandos en siete hospitales de Colombia

Biomédica: revista del Instituto Nacional de Salud, 2018
Introducción. Staphylococcus aureus resistente a meticilina (SARM) causa infecciones graves de la piel y los tejidos blandos en los hospitales y, en los últimos años, en la comunidad.
Aura Lucía Leal, María Victoria Ovalle, Jorge Alberto Cortés, Anita María Montañes, Zandra Rocío de la Rosa, José Yesid Rodríguez, Sandra Gualtero, Beatriz Ariza, Otto Sussman, María del Pilar Torres   +9 more
doaj   +1 more source

Colonización nasal por Staphylococcus aureus resistente a la meticilina en pacientes sometidos a cirugía cardiovascular en un hospital universitario de Bogotá, Colombia

Biomédica: revista del Instituto Nacional de Salud, 2020
Introducción. Staphylococcus aureus resistente a la meticilina (SARM) es un microorganismo que coloniza las fosas nasales y diferentes partes del cuerpo, lo cual se considera un factor de riesgo para adquirir infecciones invasivas, especialmente en ...
Heidy C. Martínez-Díaz, Sandra L. Valderrama-Beltrán, Ana C. Hernández, Silvia K. Pinedo, Juan R. Correa, Édgar G. Ríos, Julie J. Rojas, Yessica Y. Hernández, Marylin Hidalgo   +8 more
doaj   +1 more source

Quantification of the Carboxylated LGD‐4033 Long‐Term Metabolite in Human Micro‐Dose Excretion Study Urine Samples

Drug Testing and Analysis, Volume 18, Issue 10, Page 1321-1327, October 2026.
A validated LC‐HRMS/MS method enabled the first quantitative determination of the LGD‐4033 long‐term metabolite (M5‐b) in urine following controlled micro‐dose administration. The generated urinary reference data support the interpretation of adverse analytical findings and anti‐doping result management. ABSTRACT Selective androgen receptor modulators (
Panagiotis Sakellariou, Sebastian Marcel Schröder, Jasmin Thelen, Linus Korsmeier, Sven Guddat, Christian Görgens, Andreas Thomas, Mario Thevis   +7 more
wiley   +1 more source

Effects of a Selective Androgen Receptor Modulator (SARM), GSK2849446A, on Stress Urinary Incontinence and Bladder Activity in Rats with Ovariectomy-induced Estrogen Deficiency

BJU International, 2020
To report the effect of a selective androgen receptor modulators (SARMs) on the urethral continence mechanisms in a rat model of stress urinary incontinence (SUI) induced by bilateral ovariectomy (OVX).
K. Kadekawa, N. Kawamorita, Takahiro Shimizu, M. Kurobe, P. Turnbull, Sundeep Chandra, T. Kambara, Joanna C Barton, Alan J. Russell, N. Yoshimura   +9 more
semanticscholar   +1 more source

IS SARM - Selective Androgen Receptor Modulator: A Chance for Therapeutic Approach in Muscle-Wasting Chronic Conditions?

Purpose of review. The purpose of this paper is to review the current concepts regard­ing a new-old pharmacological class, SARM (Selective Androgen Receptor Modula­tor).
Oliva, G., Oliva, F., Maffulli, N., Bartoli, A., Ziello, S.   +4 more
core   +1 more source

Cambios a lo largo del tiempo en la distribución de los complejos de clones dominantes de Staphylococcus aureus resistente a la meticilina en Medellín, Colombia

Biomédica: revista del Instituto Nacional de Salud, 2014
Introducción. Parte del éxito de Staphylococcus aureus resistente a la meticilina (SARM) como patógeno se debe a la rápida diseminación de linajes pandémicos con perfiles variables de virulencia y sensibilidad antimicrobiana.
Ana M. Ocampo, Lázaro A. Vélez, Jaime Robledo, Judy Natalia Jiménez   +3 more
doaj   +1 more source

Sequential Association Rule Mining for Autonomously Extracting Hierarchical Task Structures in Reinforcement Learning

IEEE Access, 2020
Reinforcement learning (RL) techniques, while often powerful, can suffer from slow learning speeds, particularly in high dimensional spaces or in environments with sparse rewards.
Behzad Ghazanfari, Fatemeh Afghah, Matthew E. Taylor   +2 more
doaj   +1 more source