Results 61 to 70 of about 6,398 (198)

Transient Silencing of Antibiotic Resistance by Mutation Represents a Significant Potential Source of Unanticipated Therapeutic Failure

open access: yesmBio, 2019
Sporadic literature reports describe isolates of pathogenic bacteria that harbor an antibiotic resistance determinant but remain susceptible to the corresponding antibiotic as a consequence of a genetic defect.
Louise Kime   +8 more
doaj   +1 more source

Current Approaches to Support Patients to Withdraw From Image and Performance Enhancing Drugs

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Image and performance‐enhancing drugs (IPEDs) include agents such as androgens, growth hormone, and erythropoietin, which are used to enhance appearance and physical performance. Androgens, also known as anabolic‐androgenic steroids (AAS), are the most used IPEDs worldwide.
Elizabeth Hyams   +3 more
wiley   +1 more source

The ‘SAR Matrix’ method and its extensions for applications in medicinal chemistry and chemogenomics [v2; ref status: indexed, http://f1000r.es/3rg]

open access: yesF1000Research, 2014
We describe the ‘Structure-Activity Relationship (SAR) Matrix’ (SARM) methodology that is based upon a special two-step application of the matched molecular pair (MMP) formalism.
Disha Gupta-Ostermann, Jürgen Bajorath
doaj   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

open access: yesThe FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu   +2 more
wiley   +1 more source

Appraisal of Six Natural Mica Reference Materials for In Situ Rb‐Sr Geochronology

open access: yesGeostandards and Geoanalytical Research, EarlyView.
Key Points Evaluated six natural mica reference materials for in situ LA‐ICP‐MS/MS Rb‐Sr geochronology using geochemical, microstructural and isotopic characterisation. Identified robust primary reference materials: Mount Dromedary biotite (99.37 Ma) and Mica‐Fe biotite (307.75 Ma). La Posta biotite and Högsbo muscovite are suitable secondary reference
Hugo K.H. Olierook   +38 more
wiley   +1 more source

S. aureus resistent a la meticil·lina (SARM): epidemiologia i estratègies de prevenció [PDF]

open access: yes, 2015
Staphylococcus aureus resistent a la meticil·lina; SARM; Epidemiologia; PrevencióMethicillin-resistant Staphylococcus aureus; SARM; Epidemiology; PreventionStaphylococcus aureus resistente a la meticilina; SARM; Epidemiología; PrevenciónComunicació sobre
Sopena, Nieves
core  

The MacBrain Resource Center (MBRC) rhesus macaque postnatal brain histology datasets: Enabling new discoveries through NHP tissue and digital data Repositories

open access: yesJournal of Anatomy, EarlyView.
The MacBrain Resource Center (MBRC) postnatal rhesus macaque brain histology datasets are organized into Collections that promote cost‐effective de novo research. This article provides examples from Collections 5, 6, and 7 and describes the histo‐ and immunohistochemical (IHC) processing of materials for Collection 6.
Valeria Mendoza‐Silva   +19 more
wiley   +1 more source

Subcortical Atlas of the Rhesus Macaque (SARM) for Magnetic Resonance Imaging

open access: yesbioRxiv, 2020
Digitized neuroanatomical atlases are crucial for localizing brain structures and analyzing functional networks identified by magnetic resonance imaging (MRI).
R. Hartig   +7 more
semanticscholar   +1 more source

Identificación molecular de Staphylococcus aureus resistente a Meticilina SARM

open access: yes, 2021
Resumen: El presente trabajo se desarrolló con el objetivo principal de identificar molecularmente SARM mediante PCR. Usando (n=75) muestras pertenecientes a un cepario previamente identificado fenotípicamente en los laboratorios de microbiología de la ...
Carrión Santin, Kevin Israel
core  

How Do SMEs Respond to Deglobalization? Insights from Italian SMEs in the Interwar Period (1936–1943)

open access: yesJournal of Management Studies, EarlyView.
Abstract This study investigates how small and medium‐sized enterprises (SMEs) respond to deglobalization and economic nationalism, using historical evidence from fascist Italy, a period of autarky and restricted international trade. While prior research has focused primarily on larger firms, especially multinational enterprises (MNEs), the strategic ...
Valeria Giacomin, Francesco Romagnoli
wiley   +1 more source

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