Results 61 to 70 of about 11,053 (212)

Model-Driven Engineering for Trusted Embedded Systems based on Security and Dependability Patterns [PDF]

, 2013
National audienceNowadays, many practitioners express their worries about current software engineering practices. New recommendations should be considered to ground software engineering on two pillars: solid theory and proven principles.
Bruel, Jean-Michel, Geisel, Jacob, Hamid, Brahim, Perez, Jon, Ziani, Adel   +4 more
core   +2 more sources

Optimizing Ligand Efficiency of Selective Androgen Receptor Modulators (SARMs) [PDF]

ACS Medicinal Chemistry Letters, 2015
A series of selective androgen receptor modulators (SARMs) containing the 1-(trifluoromethyl)benzyl alcohol core have been optimized for androgen receptor (AR) potency and drug-like properties. We have taken advantage of the lipophilic ligand efficiency (LLE) parameter as a guide to interpret the effect of structural changes on AR activity.
Anthony L, Handlon, Lee T, Schaller, Lisa M, Leesnitzer, Raymond V, Merrihew, Chuck, Poole, John C, Ulrich, Joseph W, Wilson, Rodolfo, Cadilla, Philip, Turnbull   +8 more
openaire   +2 more sources

Laguna Fuente de Piedra: An example of a dolomite factory recording ~50,000 years of depositional and paleoclimatic evolution

The Depositional Record, Volume 12, Issue 1, February 2026.
This study characterises carbonate mineral precipitation mechanisms and their paleoenvironmental implications in a semi‐arid, saline playa lake system. SEM image with EDS spectra shows microcrystalline, spherical shaped dolomite crystals from Laguna Fuente de Piedra composed of nanocrystals with bacterial voids and EPS.
Zeina Naim, Guolai Li, Luis Gibert, Jan‐Berend Stuut, Gonzalo Jiménez‐Moreno, Mónica Sánchez‐Román   +5 more
wiley   +1 more source

Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans

Cell Reports, 2023
Summary: Wallerian axonal degeneration (WD) does not occur in the nematode C. elegans, in contrast to other model animals. However, WD depends on the NADase activity of SARM1, a protein that is also expressed in C. elegans (ceSARM/ceTIR-1).
Tami Khazma, Atira Grossman, Julia Guez-Haddad, Chengye Feng, Hadas Dabas, Radhika Sain, Michal Weitman, Ran Zalk, Michail N. Isupov, Marc Hammarlund, Michael Hons, Yarden Opatowsky   +11 more
doaj   +1 more source

Further Insights Into the Metabolism of LGD‐4033 in Human Urine. Part 1. Structure Elucidation of Additional Important Metabolites

Drug Testing and Analysis, Volume 18, Issue 2, Page 245-259, February 2026.
Well‐characterized, chemically synthesized molecules related to LGD‐4033 metabolism were used as analytical standards for the analysis of LGD‐4033 post‐administration urine samples. This approach offered further insights into LGD‐4033 metabolism, providing solid experimental proof for the structure of important previously reported metabolites and ...
Yiannis S. Angelis, Panagiotis Sakellariou, Mario Thevis, Andreas Thomas, Michael Petrou, Emmanuel N. Pitsinos   +5 more
wiley   +1 more source

Colonización nasal por Staphylococcus aureus resistente a la meticilina en pacientes sometidos a cirugía cardiovascular en un hospital universitario de Bogotá, Colombia

Biomédica: revista del Instituto Nacional de Salud, 2020
Introducción. Staphylococcus aureus resistente a la meticilina (SARM) es un microorganismo que coloniza las fosas nasales y diferentes partes del cuerpo, lo cual se considera un factor de riesgo para adquirir infecciones invasivas, especialmente en ...
Heidy C. Martínez-Díaz, Sandra L. Valderrama-Beltrán, Ana C. Hernández, Silvia K. Pinedo, Juan R. Correa, Édgar G. Ríos, Julie J. Rojas, Yessica Y. Hernández, Marylin Hidalgo   +8 more
doaj   +1 more source

A Model-Driven Methodology Approach for Developing a Repository of Models [PDF]

, 2014
International audienceTo cope with the growing complexity of embedded system design, several development approaches have been proposed. The most popular are those using models as main artifacts to be constructed and maintained.
A. Avizienis, B. Bislimovska, B. Hamid, C. Alexander, C. Mayr, D. Lucrédio, D. Riehle, N. Milanovic, R.B. France, Z. Yan   +9 more
core   +3 more sources

Pharmacological intervention: Challenges and promising outcomes for fat loss and preservation of lean body mass in the treatment of overweight and type 2 diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 803-816, February 2026.
Abstract Treatment with GLP‐1 receptor agonists (GLP‐1 RAs) is effective in reducing body weight in individuals with overweight and type 2 diabetes (T2D). However, measurements indicate that a considerable portion of the weight loss derives from fat‐free mass (FFM), including skeletal muscle, which may compromise metabolic health and physical function.
Viktor Aimelet, Jens Juul Holst
wiley   +1 more source

Actividad in vitro del tedizolid y de antibióticos de comparación en aislamientos de Staphylococcus aureus resistentes a meticilina en infecciones de piel y tejidos blandos en siete hospitales de Colombia

Biomédica: revista del Instituto Nacional de Salud, 2018
Introducción. Staphylococcus aureus resistente a meticilina (SARM) causa infecciones graves de la piel y los tejidos blandos en los hospitales y, en los últimos años, en la comunidad.
Aura Lucía Leal, María Victoria Ovalle, Jorge Alberto Cortés, Anita María Montañes, Zandra Rocío de la Rosa, José Yesid Rodríguez, Sandra Gualtero, Beatriz Ariza, Otto Sussman, María del Pilar Torres   +9 more
doaj   +1 more source

SARMED

, 2020
This teaching case is part of a case series that deals with the introduction of a digital multi-sided platform (MSP) – a digital space that aims at increasing collaboration, data sharing, and visibility among the actors involved in different transport and logistics environments.
Roukouni, Anastasia, Zuidwijk, Rob
openaire   +1 more source