Results 41 to 50 of about 2,201 (178)

Glucagon‐Like Peptide‐1 Receptor Agonist‐Based Agents and Body Composition: Filling More Gaps

Obesity, EarlyView.
ABSTRACT The last 2 decades have seen historic advances in the treatment of obesity. We are entering an era of defining obesity not by weight‐based outcomes but by changes in body composition. Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are forming the platform for obesity treatments based on their high level of efficacy. Body composition can
Robert L. Dubin, Tierra N. Sanders, Hunter M. Schwab, Steven B. Heymsfield, Frank L. Greenway   +4 more
wiley   +1 more source

Depositional and Hydrological Relationships Between Buried Dead Ice and the Active Layer in the McMurdo Dry Valleys, Antarctica: A Study of Sediment Geochemistry and Cation Concentrations

Permafrost and Periglacial Processes, EarlyView.
ABSTRACT The McMurdo Dry Valleys, the largest ice‐free region in Antarctica, are home to a cold‐desert hydrologic system of glaciers, snowbanks, streams, and lakes. Freshwater is also stored as dead glacial ice, which is poorly constrained in terms of ion concentrations and interactions with both in situ and overlying sediments.
Matthew C. Witscheber, Kate M. Swanger
wiley   +1 more source

Current Approaches to Support Patients to Withdraw From Image and Performance Enhancing Drugs

Clinical Endocrinology, EarlyView.
ABSTRACT Image and performance‐enhancing drugs (IPEDs) include agents such as androgens, growth hormone, and erythropoietin, which are used to enhance appearance and physical performance. Androgens, also known as anabolic‐androgenic steroids (AAS), are the most used IPEDs worldwide.
Elizabeth Hyams, Bonnie Grant, Richard Quinton, Channa N. Jayasena   +3 more
wiley   +1 more source

Colonización nasal por Staphylococcus aureus resistente a la meticilina en pacientes sometidos a cirugía cardiovascular en un hospital universitario de Bogotá, Colombia

Biomédica: revista del Instituto Nacional de Salud, 2020
Introducción. Staphylococcus aureus resistente a la meticilina (SARM) es un microorganismo que coloniza las fosas nasales y diferentes partes del cuerpo, lo cual se considera un factor de riesgo para adquirir infecciones invasivas, especialmente en ...
Heidy C. Martínez-Díaz, Sandra L. Valderrama-Beltrán, Ana C. Hernández, Silvia K. Pinedo, Juan R. Correa, Édgar G. Ríos, Julie J. Rojas, Yessica Y. Hernández, Marylin Hidalgo   +8 more
doaj   +1 more source

Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans

Cell Reports, 2023
Summary: Wallerian axonal degeneration (WD) does not occur in the nematode C. elegans, in contrast to other model animals. However, WD depends on the NADase activity of SARM1, a protein that is also expressed in C. elegans (ceSARM/ceTIR-1).
Tami Khazma, Atira Grossman, Julia Guez-Haddad, Chengye Feng, Hadas Dabas, Radhika Sain, Michal Weitman, Ran Zalk, Michail N. Isupov, Marc Hammarlund, Michael Hons, Yarden Opatowsky   +11 more
doaj   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

Actividad in vitro del tedizolid y de antibióticos de comparación en aislamientos de Staphylococcus aureus resistentes a meticilina en infecciones de piel y tejidos blandos en siete hospitales de Colombia

Biomédica: revista del Instituto Nacional de Salud, 2018
Introducción. Staphylococcus aureus resistente a meticilina (SARM) causa infecciones graves de la piel y los tejidos blandos en los hospitales y, en los últimos años, en la comunidad.
Aura Lucía Leal, María Victoria Ovalle, Jorge Alberto Cortés, Anita María Montañes, Zandra Rocío de la Rosa, José Yesid Rodríguez, Sandra Gualtero, Beatriz Ariza, Otto Sussman, María del Pilar Torres   +9 more
doaj   +1 more source

The MacBrain Resource Center (MBRC) rhesus macaque postnatal brain histology datasets: Enabling new discoveries through NHP tissue and digital data Repositories

Journal of Anatomy, EarlyView.
The MacBrain Resource Center (MBRC) postnatal rhesus macaque brain histology datasets are organized into Collections that promote cost‐effective de novo research. This article provides examples from Collections 5, 6, and 7 and describes the histo‐ and immunohistochemical (IHC) processing of materials for Collection 6.
Valeria Mendoza‐Silva, Lucy Greene, Emma Burke, Cristina Canales, Julia Chocarro, Jose L. Lanciego, Khuleshwari Kurrey, Phil Barello, Aya Nusir, Nadine Kabbani, Kathleen S. Rockland, Dibyadeep Datta, Jon I. Arellano, Amy F. T. Arnsten, Yury M. Morozov, Bashir Ahmed, Zoltán Molnár, Caroline J. Zeiss, Pasko Rakic, Alvaro Duque   +19 more
wiley   +1 more source

Cambios a lo largo del tiempo en la distribución de los complejos de clones dominantes de Staphylococcus aureus resistente a la meticilina en Medellín, Colombia

Biomédica: revista del Instituto Nacional de Salud, 2014
Introducción. Parte del éxito de Staphylococcus aureus resistente a la meticilina (SARM) como patógeno se debe a la rápida diseminación de linajes pandémicos con perfiles variables de virulencia y sensibilidad antimicrobiana.
Ana M. Ocampo, Lázaro A. Vélez, Jaime Robledo, Judy Natalia Jiménez   +3 more
doaj   +1 more source

Sequential Association Rule Mining for Autonomously Extracting Hierarchical Task Structures in Reinforcement Learning

IEEE Access, 2020
Reinforcement learning (RL) techniques, while often powerful, can suffer from slow learning speeds, particularly in high dimensional spaces or in environments with sparse rewards.
Behzad Ghazanfari, Fatemeh Afghah, Matthew E. Taylor   +2 more
doaj   +1 more source