Results 41 to 50 of about 6,398 (198)

Follow-up: Prospective compound design using the ‘SAR Matrix’ method and matrix-derived conditional probabilities of activity [v2; ref status: indexed, http://f1000r.es/59v]

F1000Research, 2015
In a previous Method Article, we have presented the ‘Structure-Activity Relationship (SAR) Matrix’ (SARM) approach. The SARM methodology is designed to systematically extract structurally related compound series from screening or chemical optimization ...
Disha Gupta-Ostermann, Yoichiro Hirose, Takenao Odagami, Hiroyuki Kouji, Jürgen Bajorath   +4 more
doaj   +1 more source

Étude transcriptomique de Staphylococcus aureus résistant à la méthicilline (SARM) [PDF]

, 2008
La résistance aux antibiotiques est un sujet d'actualité qui inquiète beaucoup la communauté scientifique et de plus en plus la population y est sensibilisée.
Pruneau, Mireille
core   +1 more source

Inhibition of apoptosis by SARM.

, 2013
HEK 293 cells transfected with the designated constructs were stimulated 18 h after transfection with TNFα and Actinomycin-D (Act-D) for the times indicated to induce apoptosis, then stained with fluorescently-labeled anti-CD90 (Thy1.1 surface marker ...
Jacek Hawiger (334056), Chad R. Sethman (438889)   +1 more
core   +1 more source

Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM.

Immunity, 2019
Assembly of inflammasomes after infection or injury leads to the release of interleukin-1β (IL-1β) and to pyroptosis. After inflammasome activation, cells either pyroptose or enter a hyperactivated state defined by IL-1β secretion without cell death, but
Michael Carty, J. Kearney, Katharine A. Shanahan, E. Hams, Ryoichi Sugisawa, D. Connolly, Ciara G. Doran, Natalia Muñoz‐Wolf, Claudia Gürtler, K. Fitzgerald, E. Lavelle, P. Fallon, A. Bowie   +12 more
semanticscholar   +1 more source

Overcoming resistance to anabolic SARM therapy in experimental cancer cachexia with an HDAC inhibitor

EMBO Molecular Medicine, 2020
No approved therapy exists for cancer‐associated cachexia. The colon‐26 mouse model of cancer cachexia mimics recent late‐stage clinical failures of anabolic anti‐cachexia therapy and was unresponsive to anabolic doses of diverse androgens, including the
Sophia G. Liva, Yu-Chou Tseng, Anees M. Dauki, Michael G. Sovic, T. Vu, Sally E. Henderson, Yi-Chiu Kuo, J. Benedict, Xiao-Li Zhang, Bryan C Remaily, S. Kulp, M. Campbell, T. Bekaii-Saab, M. Phelps, Ching S. Chen, C. Coss   +15 more
semanticscholar   +1 more source

La colonisation par SARM

, 2008
Staphylococcus aureus est un pathogène important dans les infections humaines. Il a toujours posé de grands problèmes thérapeutiques car, dès les années 1970, des clones résistants aux antibiotiques, et notamment à la méticilline (SARM), se sont ...
Henri B. Drugeon
core   +1 more source

Portage nasal de Staphylococcus aureus résistant à la méticilline chez des volontaires sains et des malades hospitalisés à Ouagadougou, Burkina Faso

Revue Malienne d’Infectiologie et de Microbiologie, 2020
Objectifs: Le but de cette étude était de déterminer la prévalence du portage de Staphylococcus aureus résistant à la méticilline (SARM), d´identifier les types de résistances et d'en analyser les facteurs.
S Sore, Y Sawadogo, S Sanou, S Beogo, SNP Dakouo, MD Djamalladine, et. al   +6 more
doaj   +1 more source

A SARM a Day Keeps the Weakness Away: A Computational Approach for Selective Androgen Receptor Modulators (SARMs) and Their Interactions with Androgen Receptor and 5‑Alpha Reductase Proteins

ACS Omega
This study examines the molecular interactions of selective androgen receptor modulators (SARMs) with the androgen receptor (AR) and 5-alpha reductase II (5αRII), highlighting their potential as dual-action pharmacological candidates, using molecular ...
M. M. M. Dahleh, S. Boeira, H. Segat, G. Guerra, Marina Prigol   +4 more
semanticscholar   +1 more source

Translation and Cross‐Cultural Adaptation of the Chronic Rhinosinusitis Control Test for Global Use

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Introduction The Chronic Rhinosinusitis Control Test (CRCT) is a patient‐reported outcome measure (PROM) written in English that is psychometrically validated to measure chronic rhinosinusitis control. Because the availability of translated PROMs is a driver of data equity—collection of data that is fair and generally representative—our ...
Hye K. Pae, Detong Xia, Hanzhong Sun, Yudi Chen, Kwangoh Yi, Minjeong Song, Eriko Sato, Ali R. Abasi, Jody Ballah, Anna Babarczy, Raymond Bertram, Agnieszka Biernacka, Mable Chan, Teresa Civera, Irina Dubinina, Doğu Erdener, María Isabel Maldonado García, Ali Garib, Tuomo Häikiö, Fuk‐chuen HO, Li‐Yu Hung, R. Malatesha Joshi, Oksana Kanerva, Kiranpreet Kaur Baath, Björn Köhnlein, Dalibor Kučera, Paula Luegi, Yustinus Calvin Gai Mali, Sivan Medina, Stefan Milosavljević, Amna Mirza, Mohamed Y. Mwamzandi, Fatemeh Nami, Anabella‐Gloria Niculescu‐Gorpin, Portia Padilla, Georgia Panayiotou, Manuel Perea, Luciano Perondi, Hiển Phạm, Rasmus Puggaard‐Rode, Anurag Rimzhim, Sreeparna Sarkar, David L. Share, Gláucia V. Silva, Antônio R. M. Simões, Charlotte Stormbom, Titima Suthiwan, Katsuo Tamaoka, Mila Tasseva‐Kurktchieva, Paweł Urbanik, An Van, Katie M. Phillips, Ahmad R. Sedaghat   +52 more
wiley   +1 more source

LncRNA pol-lnc78 as a ceRNA regulates antibacterial responses via suppression of pol-miR-n199-3p-mediated SARM down-regulation in Paralichthys olivaceus

Zoological Research
Long non-coding RNAs (lncRNAs) function as key modulators in mammalian immunity, particularly due to their involvement in lncRNA-mediated competitive endogenous RNA (ceRNA) crosstalk.
Xian-Hui Ning, Bing Han, Ye Peng, Shaowu Yin   +3 more
semanticscholar   +1 more source