Results 41 to 50 of about 3,612 (205)

Litopenaeus vannamei sterile-alpha and armadillo motif containing protein (LvSARM) is involved in regulation of Penaeidins and antilipopolysaccharide factors.

PLoS ONE, 2013
The Toll-like receptor (TLR)-mediated NF-κB pathway is tightly controlled because overactivation may result in severe damage to the host, such as in the case of chronic inflammatory diseases and cancer.
Pei-Hui Wang, Zhi-Hua Gu, Ding-Hui Wan, Wei-Bin Zhu, Wei Qiu, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He   +7 more
doaj   +1 more source

Effects of testosterone and high‐dose anabolic steroids on orthodontic‐induced bone remodeling and root resorption: An animal study

Journal of Periodontology, EarlyView.
Abstract Background This study investigates the impact of disruptions in testosterone levels on bone remodeling, root resorption, and periodontal ligament (PDL) during orthodontic tooth movement (OTM) in a pubertal male rat model. Methods Testosterone deficiency was induced through orchiectomy, and the anabolic‐androgenic steroid (AAS, testosterone ...
Caio Luiz Bitencourt Reis, Kelly Galisteu‐Luiz, Gabriela Leite Pedroso, Gustavo Lopes Puls, Leticia Cassaro, Bruno Boaventura Vieira, Fábio Lourenço Romano, Erika Calvano Küchler, Christian Kirschneck, Daniela Silva Barroso de Oliveira, Maria Bernadete Sasso Stuani, Mirian Aiko Nakane Matsumoto   +11 more
wiley   +1 more source

The ‘SAR Matrix’ method and its extensions for applications in medicinal chemistry and chemogenomics [v1; ref status: indexed, http://f1000r.es/3gh]

F1000Research, 2014
We describe the ‘Structure-Activity Relationship (SAR) Matrix’ (SARM) methodology that is based upon a special two-step application of the matched molecular pair (MMP) formalism.
Disha Gupta-Ostermann, Jürgen Bajorath
doaj   +1 more source

Effects of deficit irrigation and biostimulants on melon productivity and quality in semi‐arid conditions

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Water scarcity and soil salinization are major constraints to irrigated agriculture in semi‐arid regions, affecting crop productivity and fruit quality. Combining deficit irrigation with biostimulant application has emerged as a promising strategy to improve water use efficiency and plant stress tolerance.
Jefferson dos Santos Gomes Calaça, Jean Carlos Nogueira, José Raliuson Inácio Silva, Denizard Oresca, Alan Cezar Bezerra, Raquele Mendes de Lira, George do Nascimento Araújo Júnior, Luiz Guilherme Medeiros Pessoa, Agda Raiany Mota dos Santos, Sidney Antônio da Silva, Guilherme Heverton Lima e Silva, Douglas Nogueira Lima, Eduardo Soares de Souza   +12 more
wiley   +1 more source

Multiproxy Chronologies of the Hurd Rock Glacier (Livingston Island, South Shetland Islands, Maritime Antarctica): Between the Late‐Stage Stabilization and Flow Deceleration

Permafrost and Periglacial Processes, EarlyView.
ABSTRACT The Hurd Rock Glacier, located on Livingston Island (South Shetland Islands archipelago, Maritime Antarctica), is a tongue‐shaped feature composed of angular boulders, displaying transverse ridges and furrows, and featuring lobate structures, which are more prominently developed in its frontal sector.
Rosana Menéndez‐Duarte, Jesús Ruiz‐Fernández, Laura Rodríguez‐Rodríguez, José M. Fernández‐Fernández, Vincent Rinterknecht, ASTER Team   +5 more
wiley   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

Identificación molecular de Staphylococcus aureus resistente a Meticilina SARM

, 2021
Resumen: El presente trabajo se desarrolló con el objetivo principal de identificar molecularmente SARM mediante PCR. Usando (n=75) muestras pertenecientes a un cepario previamente identificado fenotípicamente en los laboratorios de microbiología de la ...
Carrión Santin, Kevin Israel
core  

Transient Silencing of Antibiotic Resistance by Mutation Represents a Significant Potential Source of Unanticipated Therapeutic Failure

mBio, 2019
Sporadic literature reports describe isolates of pathogenic bacteria that harbor an antibiotic resistance determinant but remain susceptible to the corresponding antibiotic as a consequence of a genetic defect.
Louise Kime, Christopher P. Randall, Frank I. Banda, Francesc Coll, John Wright, Joseph Richardson, Joanna Empel, Julian Parkhill, Alex J. O’Neill   +8 more
doaj   +1 more source

The MacBrain Resource Center (MBRC) rhesus macaque postnatal brain histology datasets: Enabling new discoveries through NHP tissue and digital data Repositories

Journal of Anatomy, EarlyView.
The MacBrain Resource Center (MBRC) postnatal rhesus macaque brain histology datasets are organized into Collections that promote cost‐effective de novo research. This article provides examples from Collections 5, 6, and 7 and describes the histo‐ and immunohistochemical (IHC) processing of materials for Collection 6.
Valeria Mendoza‐Silva, Lucy Greene, Emma Burke, Cristina Canales, Julia Chocarro, Jose L. Lanciego, Khuleshwari Kurrey, Phil Barello, Aya Nusir, Nadine Kabbani, Kathleen S. Rockland, Dibyadeep Datta, Jon I. Arellano, Amy F. T. Arnsten, Yury M. Morozov, Bashir Ahmed, Zoltán Molnár, Caroline J. Zeiss, Pasko Rakic, Alvaro Duque   +19 more
wiley   +1 more source

Molécules antibactériennes issues des huiles essentielles et activités anti-SARM

, 2022
Staphylococcus aureus est une bactérie pathogène responsable de maladies infectieuse mortelle. Le S.aureusrésistante à la méticilline pose un problème de traitement, car elle possède un fort pouvoir adaptatif et de développé différents mécanismes de ...
Tourabi, Chaimaa, Charef, Ines
core