Results 31 to 40 of about 3,612 (205)
ARS Medica, 2022 Introducción: Staphylococcus aureus, es la principal causa de bacteriemia infecciosa y endocarditis, así como de infecciones osteoarticulares, de piel y tejidos blandos, su reservorio principal es la mucosa nasal.
Alvaro Luis Fajardo Zapata +1 more
doaj +1 more source
F1000Research, 2015 In a previous Method Article, we have presented the ‘Structure-Activity Relationship (SAR) Matrix’ (SARM) approach. The SARM methodology is designed to systematically extract structurally related compound series from screening or chemical optimization ...
Disha Gupta-Ostermann +4 more
doaj +1 more source
The Pan African Medical Journal, 2016 INTRODUCTION: staphylocoque aureus reste un pathogène majeur de l'homme causant des infections très diverses, cutanées, urinaires, pulmonaires ainsi que des septicémies.
Mohamed Lemine Ould Salem +3 more
doaj +1 more source
Iterative DeepSARM modeling for compound optimization
Artificial Intelligence in the Life Sciences, 2021 The Structure-Activity Relationship (SAR) Matrix (SARM) method systematically extracts structurally related compound series from any source and organizes these series in a unique data structure formed by matrices similar to R-group tables from medicinal ...
Atsushi Yoshimori, Jürgen Bajorath
doaj +1 more source
SARM: From immune regulator to cell executioner
Biochemical Pharmacology, 2019 SARM is the fifth and most conserved member of the Toll/Il-1 Receptor (TIR) adaptor family. However, unlike the other TIR adaptors, MyD88, Mal, TRIF and TRAM, SARM does not participate in transducing signals downstream of TLRs. By contrast SARM inhibits TLR signalling by interacting with the adaptors TRIF and MyD88.
Bowie, Andrew, Carty, Michael
openaire +4 more sources
F1000Research, 2015 In a previous Method Article, we have presented the ‘Structure-Activity Relationship (SAR) Matrix’ (SARM) approach. The SARM methodology is designed to systematically extract structurally related compound series from screening or chemical optimization ...
Disha Gupta-Ostermann +4 more
doaj +1 more source
SARM modulates MyD88-mediated TLR activation through BB-loop dependent TIR-TIR interactions. [PDF]
, 2015 Toll-like receptors (TLRs) recognise invading pathogens and initiate an innate immune response by recruiting intracellular adaptor proteins via heterotypic Toll/interleukin-1 receptor (TIR) domain interactions.
Carlsson, E, Ding, JL, Byrne, B
core +1 more source
Inhibition of apoptosis by SARM.
, 2013 HEK 293 cells transfected with the designated constructs were stimulated 18 h after transfection with TNFα and Actinomycin-D (Act-D) for the times indicated to induce apoptosis, then stained with fluorescently-labeled anti-CD90 (Thy1.1 surface marker ...
Jacek Hawiger (334056) +1 more
core +1 more source
Revue Malienne d’Infectiologie et de Microbiologie, 2020 Objectifs: Le but de cette étude était de déterminer la prévalence du portage de Staphylococcus aureus résistant à la méticilline (SARM), d´identifier les types de résistances et d'en analyser les facteurs.
S Sore +6 more
doaj +1 more source
A security adaptation reference monitor (SARM) for highly dynamic wireless environments
, 2020 Since Wireless and mobile networks have become increasingly heterogeneous and particularly dynamic, multiple security requirements must be addressed in a flexible and dynamic manner to cope with runtime changing context.
El Maliki, Tewfiq, Seigneur, Jean-Marc
core +1 more source