Results 31 to 40 of about 2,201 (178)
Iterative DeepSARM modeling for compound optimization
Artificial Intelligence in the Life Sciences, 2021 The Structure-Activity Relationship (SAR) Matrix (SARM) method systematically extracts structurally related compound series from any source and organizes these series in a unique data structure formed by matrices similar to R-group tables from medicinal ...
Atsushi Yoshimori, Jürgen Bajorath
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El tratamiento antibiótico óptimo para la neumonía por SARM: buscando "el Dorado"
Revista Electrónica de AnestesiaR, 2010 La neumonía por Staphylococcus aureus resistente a la meticilina (SARM) es una de las infecciones nosocomiales más comunes y está asociada con una elevada mortalidad y coste sanitario. De hecho, la tasa de mortalidad hospitalaria asociada con infecciones
Santiago Ernesto Denis, Emilio Maseda
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Revue Malienne d’Infectiologie et de Microbiologie, 2020 Objectifs: Le but de cette étude était de déterminer la prévalence du portage de Staphylococcus aureus résistant à la méticilline (SARM), d´identifier les types de résistances et d'en analyser les facteurs.
S Sore +6 more
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PLoS ONE, 2013 The Toll-like receptor (TLR)-mediated NF-κB pathway is tightly controlled because overactivation may result in severe damage to the host, such as in the case of chronic inflammatory diseases and cancer.
Pei-Hui Wang +7 more
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Translation and Cross‐Cultural Adaptation of the Chronic Rhinosinusitis Control Test for Global Use
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Introduction The Chronic Rhinosinusitis Control Test (CRCT) is a patient‐reported outcome measure (PROM) written in English that is psychometrically validated to measure chronic rhinosinusitis control. Because the availability of translated PROMs is a driver of data equity—collection of data that is fair and generally representative—our ...
Hye K. Pae +52 more
wiley +1 more source
F1000Research, 2014 We describe the ‘Structure-Activity Relationship (SAR) Matrix’ (SARM) methodology that is based upon a special two-step application of the matched molecular pair (MMP) formalism.
Disha Gupta-Ostermann, Jürgen Bajorath
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Drug Testing and Analysis, EarlyView.A validated LC‐HRMS/MS method enabled the first quantitative determination of the LGD‐4033 long‐term metabolite (M5‐b) in urine following controlled micro‐dose administration. The generated urinary reference data support the interpretation of adverse analytical findings and anti‐doping result management. ABSTRACT Selective androgen receptor modulators (
Panagiotis Sakellariou +7 more
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mBio, 2019 Sporadic literature reports describe isolates of pathogenic bacteria that harbor an antibiotic resistance determinant but remain susceptible to the corresponding antibiotic as a consequence of a genetic defect.
Louise Kime +8 more
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Journal of Periodontology, EarlyView.Abstract Background This study investigates the impact of disruptions in testosterone levels on bone remodeling, root resorption, and periodontal ligament (PDL) during orthodontic tooth movement (OTM) in a pubertal male rat model. Methods Testosterone deficiency was induced through orchiectomy, and the anabolic‐androgenic steroid (AAS, testosterone ...
Caio Luiz Bitencourt Reis +11 more
wiley +1 more source
F1000Research, 2014 We describe the ‘Structure-Activity Relationship (SAR) Matrix’ (SARM) methodology that is based upon a special two-step application of the matched molecular pair (MMP) formalism.
Disha Gupta-Ostermann, Jürgen Bajorath
doaj +1 more source