Results 31 to 40 of about 6,398 (198)

Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- δ) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516 (Cardarine) and MK2866 (Ostarine)

Toxics, 2021
A 43-year-old male, sport coach, presented him-self at the Emergency unit of a local hospital for epigastric pain, myalgia pain and severe headache.
P. Kintz, L. Gheddar, Camille Paradis, Mickael Chinellato, A. Ameline, J. Raul, Magali Oliva-Labadie   +6 more
semanticscholar   +1 more source

Toll-1-dependent immune evasion induced by fungal infection leads to cell loss in the Drosophila brain. [PDF]

PLoS Biol
Fungi can intervene in hosts' brain function. In humans, they can drive neuroinflammation, neurodegenerative diseases and psychiatric disorders. However, how fungi alter the host brain is unknown. The mechanism underlying innate immunity to fungi is well-
Singh DND, Roberts ARE, Wang X, Li G, Quesada Moraga E, Alliband D, Ballou E, Tsai HJ, Hidalgo A.   +8 more
europepmc   +2 more sources

Staphylococcus aureus resistente a meticilina causante de infecciones comunitarias y de infecciones asociadas a la atención en salud en pacientes pediátricos del Hospital Universitario de Santander

Biomédica: revista del Instituto Nacional de Salud, 2014
Introducción. Staphylococcus aureus resistente a la meticilina (SARM) es un agente frecuente de infección en la población pediátrica. Aunque inicialmente las cepas de SARM estaban restringidas a los hospitales, se han reportado a nivel mundial brotes de ...
Mayra Alejandra Machuca, Clara Isabel González, Luis Miguel Sosa   +2 more
doaj   +1 more source

The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling. [PDF]

PLoS ONE, 2013
Sterile alpha and armadillo-motif containing protein (SARM), a highly conserved and structurally unique member of the MyD88 family of Toll-like receptor adaptors, plays an important role in innate immunity signaling and apoptosis.
Chad R Sethman, Jacek Hawiger
doaj   +1 more source

The forensic response after an adverse analytical finding (doping) involving a selective androgen receptor modulator (SARM) in human athlete.

Journal of Pharmaceutical and Biomedical Analysis, 2021
Selective androgen receptor modulators (SARMs) are a class of drugs presenting identical anabolic properties to anabolic steroids in addition to marked reduced androgenic effects.
P. Kintz
semanticscholar   +1 more source

Colonización por Staphylococcus aureus resistente a la meticilina en una unidad de cuidados intensivos de adultos de un hospital colombiano: caracterización fenotípica y molecular con detección de un clon de circulación en la comunidad

Biomédica: revista del Instituto Nacional de Salud, 2010
Introducción. Staphylococcus aureus resistente a la meticilina (SARM) causa infecciones adquiridas en la comunidad y en el ámbito hospitalario. El ser portador de SARM se ha descrito como factor de riesgo para desarrollar infección clínica.
Narda María Olarte, Ismael Alberto Valderrama, Karlo Roberto Reyes, Martha Isabel Garzón, Javier Antonio Escobar, Betsy Esperanza Castro, Natasha Vanegas   +6 more
doaj   +1 more source

Follow-up: Prospective compound design using the ‘SAR Matrix’ method and matrix-derived conditional probabilities of activity [v1; ref status: indexed, http://f1000r.es/56v]

F1000Research, 2015
In a previous Method Article, we have presented the ‘Structure-Activity Relationship (SAR) Matrix’ (SARM) approach. The SARM methodology is designed to systematically extract structurally related compound series from screening or chemical optimization ...
Disha Gupta-Ostermann, Yoichiro Hirose, Takenao Odagami, Hiroyuki Kouji, Jürgen Bajorath   +4 more
doaj   +1 more source

Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control.

Organic and biomolecular chemistry, 2018
Elucidated and validated structure of the major SARM doping drug metabolites.
Neeraj Garg, Annelie Hansson, H. Knych, S. Stanley, M. Thevis, U. Bondesson, M. Hedeland, D. Globisch   +7 more
semanticscholar   +2 more sources

Sensibilité aux antibiotiques des souches de staphylococcus aureus communautaires dans la région de Nouakchott (Mauritanie)

The Pan African Medical Journal, 2016
INTRODUCTION: staphylocoque aureus reste un pathogène majeur de l'homme causant des infections très diverses, cutanées, urinaires, pulmonaires ainsi que des septicémies.
Mohamed Lemine Ould Salem, Sidi Mohamed Ghaber, Sidi El Wafi Ould Baba, Mohamed Mahmoud Ould Maouloud   +3 more
doaj   +1 more source

Iterative DeepSARM modeling for compound optimization

Artificial Intelligence in the Life Sciences, 2021
The Structure-Activity Relationship (SAR) Matrix (SARM) method systematically extracts structurally related compound series from any source and organizes these series in a unique data structure formed by matrices similar to R-group tables from medicinal ...
Atsushi Yoshimori, Jürgen Bajorath
doaj   +1 more source