Results 31 to 40 of about 11,053 (212)
Development of selective androgen receptor modulators (SARMs) [PDF]
Molecular and Cellular Endocrinology, 2018 The Androgen Receptor (AR), a member of the steroid hormone receptor family, plays important roles in the physiology and pathology of diverse tissues. AR ligands, which include circulating testosterone and locally synthesized dihydrotestosterone, bind to and activate the AR to elicit their effects.
Ramesh Narayanan +2 more
openaire +2 more sources
F-02: Antibiothérapies anti-SARM dans le traitement probabiliste des bactériémies à Staphylococcus aureus au CHU d'Angers [PDF]
, 2014 Introduction – objectifs La résistance à la méticilline du Staphylococcus aureus (SA) ne cesse de diminuer en France. Nous avons évalué la prescription des antibiothérapies probabilistes dans les bactériémies à SA et leur impact clinique.
M. Delemotte +6 more
core +3 more sources
The Pan African Medical Journal, 2016 INTRODUCTION: staphylocoque aureus reste un pathogène majeur de l'homme causant des infections très diverses, cutanées, urinaires, pulmonaires ainsi que des septicémies.
Mohamed Lemine Ould Salem +3 more
doaj +1 more source
F1000Research, 2015 In a previous Method Article, we have presented the ‘Structure-Activity Relationship (SAR) Matrix’ (SARM) approach. The SARM methodology is designed to systematically extract structurally related compound series from screening or chemical optimization ...
Disha Gupta-Ostermann +4 more
doaj +1 more source
Molecules, 2023 Among anabolic agents, selective androgen receptor modulators (SARMs) represent a new class of potential drugs that can exhibit anabolic effects on muscle and bone with reduced side effects due to a tissue-selective mode of action.
Tristan Möller +4 more
doaj +1 more source
Sex hormone-binding globulin regulation of androgen bioactivity in vivo : validation of the free hormone hypothesis [PDF]
, 2016 Sex hormone-binding globulin (SHBG) is the high-affinity binding protein for androgens and estrogens. According to the free hormone hypothesis, SHBG modulates the bioactivity of sex steroids by limiting their diffusion into target tissues.
Antonio, Leen +15 more
core +2 more sources
Iterative DeepSARM modeling for compound optimization
Artificial Intelligence in the Life Sciences, 2021 The Structure-Activity Relationship (SAR) Matrix (SARM) method systematically extracts structurally related compound series from any source and organizes these series in a unique data structure formed by matrices similar to R-group tables from medicinal ...
Atsushi Yoshimori, Jürgen Bajorath
doaj +1 more source
F1000Research, 2015 In a previous Method Article, we have presented the ‘Structure-Activity Relationship (SAR) Matrix’ (SARM) approach. The SARM methodology is designed to systematically extract structurally related compound series from screening or chemical optimization ...
Disha Gupta-Ostermann +4 more
doaj +1 more source
An easy proof of Jensen's theorem on the uniqueness of infinity harmonic functions [PDF]
, 2009 We present a new, easy, and elementary proof of Jensen's Theorem on the uniqueness of infinity harmonic functions. The idea is to pass to a finite difference equation by taking maximums and minimums over small balls.Comment: 4 pages; comments added ...
A.M. Oberman +9 more
core +4 more sources
El tratamiento antibiótico óptimo para la neumonía por SARM: buscando "el Dorado"
Revista Electrónica de AnestesiaR, 2010 La neumonía por Staphylococcus aureus resistente a la meticilina (SARM) es una de las infecciones nosocomiales más comunes y está asociada con una elevada mortalidad y coste sanitario. De hecho, la tasa de mortalidad hospitalaria asociada con infecciones
Santiago Ernesto Denis, Emilio Maseda
doaj +1 more source