Results 51 to 60 of about 3,612 (205)

The ‘SAR Matrix’ method and its extensions for applications in medicinal chemistry and chemogenomics [v2; ref status: indexed, http://f1000r.es/3rg]

F1000Research, 2014
We describe the ‘Structure-Activity Relationship (SAR) Matrix’ (SARM) methodology that is based upon a special two-step application of the matched molecular pair (MMP) formalism.
Disha Gupta-Ostermann, Jürgen Bajorath
doaj   +1 more source

How Do SMEs Respond to Deglobalization? Insights from Italian SMEs in the Interwar Period (1936–1943)

Journal of Management Studies, EarlyView.
Abstract This study investigates how small and medium‐sized enterprises (SMEs) respond to deglobalization and economic nationalism, using historical evidence from fascist Italy, a period of autarky and restricted international trade. While prior research has focused primarily on larger firms, especially multinational enterprises (MNEs), the strategic ...
Valeria Giacomin, Francesco Romagnoli
wiley   +1 more source

SARM constructs and their nuclear transport and localization patterns.

, 2013
A. Design of SARM constructs used in this study. SARM's modular structure is comprised of ARM repeats (blue), a SAM domain (pink) and a TIR domain (orange).
Jacek Hawiger (334056), Chad R. Sethman (438889)   +1 more
core   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

S. aureus resistent a la meticil·lina (SARM): epidemiologia i estratègies de prevenció [PDF]

, 2015
Staphylococcus aureus resistent a la meticil·lina; SARM; Epidemiologia; PrevencióMethicillin-resistant Staphylococcus aureus; SARM; Epidemiology; PreventionStaphylococcus aureus resistente a la meticilina; SARM; Epidemiología; PrevenciónComunicació sobre
Sopena, Nieves
core  

Optimizing Ligand Efficiency of Selective Androgen Receptor Modulators (SARMs) [PDF]

ACS Medicinal Chemistry Letters, 2015
A series of selective androgen receptor modulators (SARMs) containing the 1-(trifluoromethyl)benzyl alcohol core have been optimized for androgen receptor (AR) potency and drug-like properties. We have taken advantage of the lipophilic ligand efficiency (LLE) parameter as a guide to interpret the effect of structural changes on AR activity.
Anthony L, Handlon, Lee T, Schaller, Lisa M, Leesnitzer, Raymond V, Merrihew, Chuck, Poole, John C, Ulrich, Joseph W, Wilson, Rodolfo, Cadilla, Philip, Turnbull   +8 more
openaire   +2 more sources

The Rising Burden of Osteosarcopenia in Older Adults: A Narrative Review of Pathophysiology, Diagnostic Challenges, and Therapeutic Perspectives

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Osteosarcopenia, defined as the coexistence of osteoporosis and sarcopenia, is an emerging geriatric syndrome linked to the musculoskeletal decline associated with aging. It is correlated with an increased risk of falls, fractures, disability, and mortality.
Javeria Taj, Rabia Zafar, Joshua Ekouo, Ayesha Junaid, Dujardin Makeda, Kinza Latif, Hermann Yokolo   +6 more
wiley   +1 more source

Colonización nasal por Staphylococcus aureus resistente a la meticilina en pacientes sometidos a cirugía cardiovascular en un hospital universitario de Bogotá, Colombia

Biomédica: revista del Instituto Nacional de Salud, 2020
Introducción. Staphylococcus aureus resistente a la meticilina (SARM) es un microorganismo que coloniza las fosas nasales y diferentes partes del cuerpo, lo cual se considera un factor de riesgo para adquirir infecciones invasivas, especialmente en ...
Heidy C. Martínez-Díaz, Sandra L. Valderrama-Beltrán, Ana C. Hernández, Silvia K. Pinedo, Juan R. Correa, Édgar G. Ríos, Julie J. Rojas, Yessica Y. Hernández, Marylin Hidalgo   +8 more
doaj   +1 more source

Arylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer [PDF]

Bioorganic & Medicinal Chemistry, 2006
A new series of androgen receptor targeted agents (ARTA) was prepared and tested in androgen-dependent and -independent prostate cancer cell lines. These agents were bicalutamide analogs with isothiocyanato substituted B-rings. Also, the linker sulfone of R-bicalutamide was maintained or replaced with several alternative linkages including ether, amine,
Dong Jin, Hwang, Jun, Yang, Huiping, Xu, Igor M, Rakov, Michael L, Mohler, James T, Dalton, Duane D, Miller   +6 more
openaire   +2 more sources

Why Osteosarcopenia Matters: Clinical and Investigative Implications

European Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.
Osteosarcopenia: Non‐pharmacological and pharmacological treatment strategies. ABSTRACT Background Osteosarcopenia, the combination of osteoporosis and sarcopenia, is a geriatric syndrome linked to functional decline, falls, and fragility fractures. The interaction among bone, muscle, and their shared pathophysiology is driven by mechanical, metabolic,
Erik Luiz Bonamigo, Marcella Nora Maia, Renata Pinheiro Cavallaro de Oliveira, Régis Gemerasca Mestriner, Ivan Aprahamian, Gustavo Duque   +5 more
wiley   +1 more source