A Prospective, Multicentre, Open-Label Single-Arm Exploratory Study to Evaluate Efficacy and Safety of Saroglitazar on Hypertriglyceridemia in HIV Associated Lipodystrophy. [PDF]
PLoS ONE, 2016 OBJECTIVE:This study was designed to explore the efficacy and safety of saroglitazar 4 mg on hypertriglyceridemia in patients with HIV associated lipodystrophy.
Alka Deshpande +3 more
doaj +2 more sources
Clinical Diabetology, 2022 OBJECTIVE: Diabetes and diabetic dyslipidemia with high triglycerides (TGs) are commonly associated. Saroglitazar is the first dual PPAR α/γ agonist approved in India for the management of diabetic dyslipidemia.
Arjun Baidya
doaj +3 more sources
To evaluate the safety and efficacy of saroglitazar among pre-diabetes and dyslipidemia
International journal of health sciences, 2022 Patients with prediabetes are not only at increased risk of progression to type 2 diabetes, but they are also at high risk of developing cardiovascular (CV) risk compared to normoglycemic people. Further, prediabetes is also often associated with abnormal lipid levels (dyslipidemia). We therefore aimed to evaluate the effect of saroglitazar in patients
Pravin G. Dhone +3 more
openaire +3 more sources
Saroglitazar Versus Simvastatin for Metabolic and Alcohol-Associated Liver Disease (MetALD). [PDF]
CureusIndividuals with steatotic liver disease who consume significant amounts of alcohol and meet at least one cardiometabolic criterion are classified as having metabolic and alcohol-associated liver disease (MetALD). The efficacy of saroglitazar and simvastatin in this population remains unclear.
Kulkarni A +4 more
europepmc +3 more sources
Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH
Metabolites, 2022 Non-alcoholic fatty liver (NAFLD) over the past years has become a metabolic pandemic linked to a collection of metabolic diseases. The nuclear receptors ERRs, REV-ERBs, RORs, FXR, PPARs, and LXR are master regulators of metabolism and liver physiology ...
Ryan D. Welch +8 more
doaj +2 more sources
Healing Effects of Saroglitazar Gel in Thermally Induced Burn in Rats [PDF]
Al-Anbar Medical JournalBackground: Burn is associated with several consequences, including an increased incidence of infection, extended duration of hospitalization, and an increased mortality rate.
Aram Ibrahim +4 more
doaj +2 more sources
Life and ScienceObjective: This study aimed to evaluate the efficacy and safety of saroglitazar and fenofibrate in treating diabetic dyslipidemia. Study Design: Comparative cross-sectional study.
Bakhtawar Farooq +4 more
doaj +2 more sources
Prospects of late-stage development agents in the treatment of metabolic dysfunction-associated steatohepatitis [PDF]
Clinical and Molecular HepatologyMetabolic dysfunction-associated steatotic liver disease (MASLD) is a spectrum of pathology involving fatty liver disease that may progress to fibrosis, cirrhosis, hepatocellular carcinoma, and liver failure.
Brian Lee +4 more
doaj +2 more sources
Role of Glitazars in atherogenic dyslipidemia and diabetes: Two birds with one stone?
Indian Journal of Endocrinology and Metabolism, 2014 A triad of high triglycerides, low high-density lipoprotein (HDL) cholesterol, and elevated small dense low-density lipoprotein particles occurring in a patient with type 2 diabetes is referred to atherogenic diabetic dyslipidemia (ADD).
Srinivasa P Munigoti, C V Harinarayan
doaj +2 more sources
PPAR-mediated reduction of lipid accumulation in hepatocytes involves the autophagy-lysosome-mitochondrion axis [PDF]
Annals of MedicineBackground and aim Lipid accumulation in hepatocytes is reduced by the activation of the peroxisome proliferator-activated receptor (PPAR) α, which is associated with increased lysosomal acid lipase (LAL) activity, transcription factor EB (TFEB ...
Federica Cetti +5 more
doaj +2 more sources