Results 71 to 80 of about 926 (182)

Epigenetic Regulation of Aging and its Rejuvenation

MedComm, Volume 6, Issue 9, September 2025.
This article provides an overview of the epigenetic mechanisms and key targets involved in aging, including DNA methylation, histone modifications, chromatin remodeling, and changes in noncoding RNAs. It also introduces various intervention strategies aimed at reversing epigenetic changes to delay aging and treat diseases.
Yongpan An, Qian Wang, Ke Gao, Chi Zhang, Yanan Ouyang, Ruixiao Li, Zhou Ma, Tong Wu, Lifan Zhou, Zhengwei Xie, Rui Zhang, Guojun Wu   +11 more
wiley   +1 more source

A comprehensive review on adaptive plasticity and recovery mechanisms post‐acquired brain injury

Neuroprotection, Volume 3, Issue 3, Page 226-252, September 2025.
This figure illustrates the dynamic process of neurogenesis following brain injury, focusing on the roles of neural stem and progenitor cells at the injury site. Key mechanisms include axonal sprouting, synaptogenesis, dendritic remodeling, and brain‐derived neurotrophic factor signaling via TrkB receptors.
Ravi Kumar Rajan
wiley   +1 more source

Suppression of TGF-β/Smad3 signaling pathway by Capparis spinosa and quercetin in a rat model of nonalcoholic steatohepatitis [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Liver diseases, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), pose significant global public health challenges.
Reza Afarin, Mahdi Hatami, Sajad Monjezi, Fatemeh Bineshfar, Akram Ahangarpour   +4 more
doaj   +1 more source

Nonalcoholic fatty liver disease: New epidemic

APIK Journal of Internal Medicine, 2021
The global obesity epidemic has dramatically increased the prevalence of nonalcoholic fatty liver disease (NAFLD), such that it is the most common cause of chronic liver disease in Western nations.
Rajkumar P Wadhwa, Deven Shrikant Gosavi, Aathira Ravindranath   +2 more
doaj   +1 more source

Macrophage Signaling Pathways in Health and Disease: From Bench to Bedside Applications

MedComm, Volume 6, Issue 7, July 2025.
Macrophage functions in phagocytosis, tissue repair, immune regulation, and neuronal network protection. And graphic abract image in the attachment. ABSTRACT Macrophages exhibit remarkable functional plasticity by dynamically polarizing into proinflammatory or antiinflammatory subsets in response to microenvironmental cues. This duality underpins their
Yongquan Chi, Haipeng Jiang, Yiyuan Yin, Xinyu Zhou, Yiyouyou Shao, Yongsheng Li, Jianhua Rao   +6 more
wiley   +1 more source

Combinations of an acetyl CoA carboxylase inhibitor with hepatic lipid modulating agents do not augment antifibrotic efficacy in preclinical models of NASH and fibrosis

Hepatology Communications, 2022
Dysregulated hepatocyte lipid metabolism is a hallmark of hepatic lipotoxicity and contributes to the pathogenesis of nonalcoholic steatohepatitis (NASH).
Archana Vijayakumar, Ayse Okesli‐Armlovich, Ting Wang, Isabel Olson, Minji Seung, Saritha Kusam, David Hollenback, Sangeetha Mahadevan, Bruno Marchand, Maria Toteva, David G. Breckenridge, James L. Trevaskis, Jamie Bates   +12 more
doaj   +1 more source

Management of metabolic dysfunction–associated steatotic liver disease (MASLD)—An expert consensus statement from Indian diabetologists' perspective

Diabetes, Obesity and Metabolism, Volume 27, Issue S4, Page 3-20, June 2025.
Abstract In India, the increasing prevalence of diabetes and obesity poses a significant threat towards a surge in the incidence of metabolic dysfunction‐associated steatotic liver disease (MASLD), formerly known as non‐alcoholic fatty liver disease (NAFLD).
Abdul Hamid Zargar, Anil Bhansali, Anirban Majumdar, Anuj Maheshwari, Arpandev Bhattacharyya, Arundhati Dasgupta, Banshi Damodarlal Saboo, Bipin Kumar Sethi, Debmalya Sanyal, Krishna G. Seshadri, Neeta Rohit Deshpande, Nitin Kapoor, Om Jitendra Lakhani, Pradeep Gopal Talwalkar, Pramila Kalra, Rabindera Nath Mehrotra, Rakesh Kumar Sahay, Rishi Shukla, Saket Kant, Sambit Das, Sanjay Chunilal Agarwal, Sanjeev Ratnakar Phatak, Shanmugasundar G., Shashank Rameshchandra Joshi, Shehla Sajid Shaikh, Sosale Ramachandra Aravind, Soumik Goswami, Sujoy Ghosh, Vijay Kumar Panikar, Viswanathan Mohan   +29 more
wiley   +1 more source

Drug‐Induced Liver Injury in Patients With Chronic Liver Disease

Liver International, Volume 45, Issue 3, March 2025.
ABSTRACT Objective Drug‐induced liver injury (DILI) is a global problem and can develop from exposure to prescription or over‐the‐counter medications as well as herbal and dietary supplements. The diagnosis of DILI is clinically challenging, and liver injury can be severe leading to liver failure, death, or liver transplantation.
Marwan Ghabril, Raj Vuppalanchi, Naga Chalasani   +2 more
wiley   +1 more source

Free Cholesterol‐Induced Liver Injury in Non‐Alcoholic Fatty Liver Disease: Mechanisms and a Therapeutic Intervention Using Dihydrotanshinone I

Advanced Science, Volume 12, Issue 2, January 13, 2025.
This study underscores the detrimental role of free cholesterol in non‐alcoholic fatty liver disease (NAFLD), demonstrating its ability to trigger a surge in reactive oxygen species (ROS) that leads to hepatocyte death. We also introduce dihydrotanshinone I (DhT), a small molecule that mitigates free cholesterol‐induced toxicity by activating ...
Jia‐Wen Shou, Juncai Ma, Xuchu Wang, Xiao‐Xiao Li, Shu‐Cheng Chen, Byung‐Ho Kang, Pang‐Chui Shaw   +6 more
wiley   +1 more source

PPARevolution. First PPARδ Agonist and a Dual PPARα/PPARδ Activator Approved for the Treatment of Primary Biliary Cholangitis

Journal of Cellular and Molecular Medicine, Volume 29, Issue 21, November 2025.
Iuliana Popescu
wiley   +1 more source